Christine Beemelmanns
Leibniz Association
Medicinal chemistryOrganic chemistryChemistryIndole testTwo-dimensional nuclear magnetic resonance spectroscopyCombinatorial chemistryKetylNatural productFungusStreptomycesSamarium diiodideTotal synthesisGene clusterSymbiosisAntimicrobialBacteriaSamariumBiochemistryCascade reactionStereochemistryBiologyMicrobiology
116Publications
20H-index
1,166Citations
Publications 97
Newest
#1Seoung Rak Lee (SKKU: Sungkyunkwan University)H-Index: 1
#2Huijuan Guo (Leibniz Association)H-Index: 19
Last. Ki-Hyun Kim (SKKU: Sungkyunkwan University)H-Index: 106
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Actinobacteria have long served as sources of novel natural products with antibiotic properties, but the isolation of novel derivatives and the determination of their absolute structures have remained a scientific challenge. The objective of this study was to clarify the absolute structures of the azalomycin core structure as previous structural assignments remained controversial. Based on the isolation of four azalomycin derivatives (F4a, F4b, F5a and F5b) from the termite-associated Streptomyc...
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#1Felix Schalk (Leibniz Association)H-Index: 2
#2Cene Gostinčar (University of Ljubljana)H-Index: 19
Last. Axel A. Brakhage (Leibniz Association)H-Index: 83
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Macrotermitine termites have domesticated fungi in the genus Termitomyces as their primary food source using predigested plant biomass. To access the full nutritional value of lignin-enriched plant biomass, the termite-fungus symbiosis requires the depolymerization of this complex phenolic polymer. While most previous work suggests that lignocellulose degradation is accomplished predominantly by the fungal cultivar, our current understanding of the underlying biomolecular mechanisms remains rudi...
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#1Benjamin H. Conlon (UCPH: University of Copenhagen)H-Index: 4
#2Cene Gostinčar (University of Ljubljana)H-Index: 19
Last. Christine Beemelmanns (Leibniz Association)H-Index: 20
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Summary null null Insights into the genomic consequences of symbiosis for basidiomycete fungi associated with social insects remain sparse. Capitalising on viability of spores from centuries-old herbarium specimens of free-living, facultative and specialist termite-associated Podaxis fungi, we obtained genomes of 10 specimens, including two type species described by Linnaeus >240 years ago. We document that the transition to termite associations was accompanied by significant reduction in genome...
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#1Felix Schalk (Leibniz Association)H-Index: 2
#2Janis Fricke (Leibniz Association)
Last. Christine Beemelmanns (Leibniz Association)H-Index: 20
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Targeted HRMS2-GNPS-based metabolomic analysis of Pseudoxylaria sp. X187, a fungal antagonist of the fungus-growing termite symbiosis, resulted in the identification of two lipopeptidic congeners of xylacremolides, named xylacremolide C and D, which are built from d-phenylalanine, l-proline and an acetyl-CoA starter unit elongated by four malonyl-CoA derived ketide units. The putative xya gene cluster was identified from a draft genome generated by Illumina and PacBio sequencing and RNAseq studi...
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#1Dávid Roman (Leibniz Institute for Neurobiology)H-Index: 2
#1Dávid Roman (Leibniz Institute for Neurobiology)
Last. Christine Beemelmanns (Leibniz Institute for Neurobiology)
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Here, we have summarized more than 30 representative natural product syntheses published in 2015 to 2020 that employ one or more Horner-Wadsworth-Emmons (HWE) reactions. We comprehensively describe the applied phosphonate reagents, HWE reaction conditions and key steps of the total synthetic approaches. Our comprehensive review will support future synthetic approaches and serve as guideline to find the best HWE conditions for the most complicated natural products known
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#1Daniel Loos (Leibniz Association)H-Index: 1
Last. Gianni PanagiotouH-Index: 27
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Trillions of microbes representing all kingdoms of life are resident in, and on, humans holding essential roles for host development and physiology. The last decade over a dozen online tools and servers, accessible via public domain, have been developed for the analysis of bacterial sequences, however, the analysis of fungi is still in its infancy. Here we present a web server dedicated to the comprehensive analysis of the human mycobiome for (i) translating raw sequencing reads to data tables a...
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#1Soohyun Um (Leibniz Association)H-Index: 9
#2Elena Seibel (Leibniz Association)H-Index: 1
Last. Christine Beemelmanns (Leibniz Association)H-Index: 20
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High-resolution tandem mass spectrometry (HR-MS2)-based metabolomic studies of Amycolatopsis saalfeldensis, isolated from the "Saalfelder Feengrotten" caves in Germany, led to the isolation of three ribosomally synthesized and post-translationally modified type II thiopeptides, saalfelduracin B-D (1-3) and the known saalfelduracin A (4). The structures of all four compounds were determined by comparative two-dimensional NMR analysis and high-resolution tandem mass spectrometry.
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#1Robert Murphy (UCPH: University of Copenhagen)H-Index: 1
#2René Benndorf (Leibniz Association)H-Index: 5
Last. Michael Poulsen (UCPH: University of Copenhagen)H-Index: 31
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Actinobacteria, one of the largest bacterial phyla, are ubiquitous in many of Earth's ecosystems and often act as defensive symbionts with animal hosts. Members of the phylum have repeatedly been isolated from basidiomycete-cultivating fungus-farming termites that maintain a monoculture fungus crop on macerated dead plant substrate. The proclivity for antimicrobial and enzyme production of Actinobacteria make them likely contributors to plant decomposition and defense in the symbiosis. To test t...
1 CitationsSource
#1Michelle A. Schorn (WUR: Wageningen University and Research Centre)H-Index: 10
#2Stefan VerhoevenH-Index: 11
Last. Justin J. J. van der Hooft (WUR: Wageningen University and Research Centre)H-Index: 32
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Genomics and metabolomics are widely used to explore specialized metabolite diversity. The Paired Omics Data Platform is a community initiative to systematically document links between metabolome and (meta)genome data, aiding identification of natural product biosynthetic origins and metabolite structures.
4 CitationsSource
#1Felix SchalkH-Index: 2
#2Cene Gostinčar (University of Ljubljana)H-Index: 19
Last. Christine BeemelmannsH-Index: 20
view all 15 authors...
Macrotermitine termites have domesticated fungi in the genus Termitomyces as their primary food source using pre-digested plant biomass. To access the full nutritional value of lignin-enriched plant biomass, the termite-fungus symbiosis requires the depolymerization of this complex phenolic polymer. While most previous work suggests that lignocellulose degradation is accomplished predominantly by the fungal cultivar, our current understanding of the underlying biomolecular mechanisms remains rud...
Source