Gail A. Laughlin
University of California, San Diego
Circadian rhythmInternal medicineEndocrinologyCardiologyCognitionProspective cohort studyHazard ratioBone mineralDehydroepiandrosteroneEstrogenMenopauseContext (language use)Body mass indexPopulationCognitive declineSex hormone-binding globulinConfidence intervalRisk factorBreast cancerTestosteroneDiabetes mellitusHormoneMedicineCohortGerontologyBiology
212Publications
65H-index
10.9kCitations
Publications 199
Newest
#1Emilie T. Reas (UCSD: University of California, San Diego)H-Index: 11
#2Gail A. Laughlin (UCSD: University of California, San Diego)H-Index: 65
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
view all 6 authors...
Midlife vascular disease increases risk for dementia and effects of vascular dysfunction on brain health differ between men and women. Elevated pulse pressure, a surrogate for arterial stiffness, contributes to cerebrovascular pathology and white matter damage that may advance cognitive aging; however, it remains unclear how associations between pulse pressure and neural integrity differ by sex and age. This study used restriction spectrum imaging to examine associations between pulse pressure a...
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#1Jonathan Davitte (UCSD: University of California, San Diego)
#2Gail A. Laughlin (UCSD: University of California, San Diego)H-Index: 65
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
view all 4 authors...
We examined the association between dietary potassium intake and all-cause and cause-specific mortality among community-dwelling older adults. Potassium intake was assessed with a food frequency questionnaire administered to 1,363 older adults (mean age 71.0 ± 10.6 years). Cox proportional hazard regressions estimated hazard ratios for sex-specific quintiles of calorie-adjusted potassium in relation to all-cause and cause-specific (cardiovascular disease, CVD, and stroke) mortality, adjusting fo...
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#1Humberto Parada (SDSU: San Diego State University)H-Index: 17
#2Gail A. Laughlin (UCSD: University of California, San Diego)H-Index: 65
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
view all 5 authors...
BACKGROUND We examined the associations between dual impairments in visual and hearing acuity and aging-related cognitive decline. METHODS This was a longitudinal study of adults who had visual and hearing acuity and cognitive function assessed in 1992-1996 and were followed for up to 24 years (mean = 7.3 years), with up to five additional cognitive assessments. Visual impairment was defined as vision worse than 20/40, hearing impairment as pure-tone average thresholds >25 dB. Associations were ...
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#1Eric L Harshfield (University of Cambridge)H-Index: 10
#2Lisa Pennells (University of Cambridge)H-Index: 16
Last. Karina W. DavidsonH-Index: 89
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Importance It is uncertain whether depressive symptoms are independently associated with subsequent risk of cardiovascular diseases (CVDs). Objective To characterize the association between depressive symptoms and CVD incidence across the spectrum of lower mood. Design, setting, and participants A pooled analysis of individual-participant data from the Emerging Risk Factors Collaboration (ERFC; 162 036 participants; 21 cohorts; baseline surveys, 1960-2008; latest follow-up, March 2020) and the U...
6 CitationsSource
#1Tinh-Hai Collet (UNIL: University of Lausanne)H-Index: 22
#2Susan K. Ewing (UCSF: University of California, San Francisco)H-Index: 28
Last. Douglas C. Bauer (UCSF: University of California, San Francisco)H-Index: 120
view all 10 authors...
Context: Observational studies show discordant links between endogenous testosterone levels and cardiovascular diseases (CVD). Objective: We assessed whether sex hormones and sex hormone-binding globulin (SHBG) are associated with CVD in community-dwelling elderly men. Design Setting and Participants: Prospective study of incident CVD among 552 men >/= 65 years in the MrOS Sleep Study without prevalent CVD and no testosterone therapy at baseline. Outcomes: Fasting serum levels of total testoster...
1 CitationsSource
#1Ali Al-Attar (UCSD: University of California, San Diego)H-Index: 16
#2Jaclyn Bergstrom (UCSD: University of California, San Diego)H-Index: 23
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
view all 9 authors...
Background: Hearing impairment is prevalent among older adults and has been identified as a risk factor for cognitive impairment and dementia. We evaluated the association of hearing impairment with long-term cognitive decline among community-dwelling older adults. Methods: A population-based longitudinal study of adults not using hearing aids who had hearing acuity and cognitive function assessed in 1992-96, and were followed for a maximum of 24 years with up to five additional cognitive assess...
20 CitationsSource
#1Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
#2Linda K McEvoy (UCSD: University of California, San Diego)
Last. Jaclyn Bergstrom (UCSD: University of California, San Diego)H-Index: 23
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#1Pedro Kremer (UCSD: University of California, San Diego)H-Index: 3
#2Gail A. Laughlin (UCSD: University of California, San Diego)H-Index: 65
Last. Andrea Z. LaCroix (UCSD: University of California, San Diego)H-Index: 42
view all 8 authors...
AbstractObjective:High consumption of soft drinks has been associated with lower bone mineral density among postmenopausal women. This study explores the association of soft drink consumption, osteoporosis, and incidental fractures in this population.Methods:Cross-sectional (at baseline) and cohort
3 CitationsSource
#1Stephen KaptogeH-Index: 58
#2Lisa PennellsH-Index: 16
Last. Emanuele Di AngelantonioH-Index: 70
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Summary Background To help adapt cardiovascular disease risk prediction approaches to low-income and middle-income countries, WHO has convened an effort to develop, evaluate, and illustrate revised risk models. Here, we report the derivation, validation, and illustration of the revised WHO cardiovascular disease risk prediction charts that have been adapted to the circumstances of 21 global regions. Methods In this model revision initiative, we derived 10-year risk prediction models for fatal an...
101 CitationsSource
#1Sindana D. Ilango (UCSD: University of California, San Diego)H-Index: 6
#2Linda K. McEvoyH-Index: 66
Last. Donna Kritz-SilversteinH-Index: 55
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OBJECTIVE: The aim of the study was to examine the association of pregnancy history with trajectories of cognitive function in older women. METHODS: Participants were 1,025 women (mean age = 73.1 ± 9.6 y) enrolled in the Rancho Bernardo Study who attended a clinic visit between 1988 and 1992, when pregnancy history (ever pregnant, number of pregnancies, ages at first and last pregnancy) was recorded and cognitive function was assessed with a battery of four tests repeated up to 7 times through 2...
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