Alexios S. Antonopoulos
National and Kapodistrian University of Athens
Internal medicineEndocrinologySurgeryCardiologyAdipose tissueAdipokineOxidative stressAdiponectinArteryInflammationEndotheliumType 2 diabetesHeart failureCoronary artery diseaseDiseaseSuperoxideEndothelial dysfunctionIn patientNitric oxideMedicine
222Publications
30H-index
3,734Citations
Publications 226
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AIMS Eosinophilic heart disease (EHD) is a rare cardiac condition with a wide spectrum of phenotypes. The diagnostic and prognostic value of cardiac magnetic resonance (CMR) in EHD remains unknown. METHODS AND RESULTS This was a retrospective analysis of 250 patients with eosinophilia referred for a CMR scan (period 2000-2020). CMR data sets and clinical/laboratory data were collected. Patients were followed up for a mean of 24 months (range 1-224) for the composite endpoint of death, acute coro...
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#1Panagiotis Theofilis (UoA: National and Kapodistrian University of Athens)H-Index: 5
#2Marios Sagris (UoA: National and Kapodistrian University of Athens)H-Index: 5
Last. Dimitris Tousoulis (UoA: National and Kapodistrian University of Athens)H-Index: 47
view all 6 authors...
Background: Atherosclerotic cardiovascular diseases are characterized by a dysregulated inflammatory and thrombotic state, leading to devastating complications with increased morbidity and mortality rates. Summary: In this review article, we present the available evidence regarding the impact of inflammation on platelet activation in atherosclerosis. Key messages: In the context of a dysfunctional vascular endothelium, structural alterations by means of endothelial glycocalyx thinning or functio...
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#1Panagiotis Theofilis (UoA: National and Kapodistrian University of Athens)H-Index: 5
#2Evangelos Oikonomou (UoA: National and Kapodistrian University of Athens)H-Index: 32
Last. Dimitris Tousoulis (UoA: National and Kapodistrian University of Athens)H-Index: 47
view all 9 authors...
Abstract null null Background null Pro-angiogenic microRNA modulation is a potentially attractive approach in the management of peripheral artery disease (PAD). The aim of this systematic review and meta-analysis was to examine the impact of microRNAs involved in the process of angiogenesis on blood flow recovery following hind limb ischemia induction in animal models. null null null Methods null A literature search was performed to identify studies testing the efficacy of microRNA treatment on ...
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#1Alexios S. Antonopoulos (UoA: National and Kapodistrian University of Athens)H-Index: 30
#2Konstantinos Tsioufis (UoA: National and Kapodistrian University of Athens)H-Index: 26
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AIMS Coronary CT angiography (CCTA) is a first-line modality in the investigation of suspected coronary artery disease (CAD). Mapping of perivascular Fat Attenuation Index (FAI) on routine CCTA enables the non-invasive detection of coronary artery inflammation by quantifying spatial changes in perivascular fat composition. We now report the performance of a new medical device, CaRi-Heart®, which integrates standardised FAI mapping together with clinical risk factors and plaque metrics to provide...
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#1Marios Sagris (UoA: National and Kapodistrian University of Athens)H-Index: 5
#2Alexios S. Antonopoulos (University of Oxford)H-Index: 30
Last. Dimitris Tousoulis (UoA: National and Kapodistrian University of Athens)H-Index: 47
view all 10 authors...
Myocardial infarction (MI) among young adults (< 45 years) represents a considerable proportion of the total heart attack incidents. The underlying pathophysiologic characteristics, atherosclerotic plaque features and risk factors profile differ between young and older patients with MI. This review article discusses the main differences between the younger and elderly MI patients as well as the different pathogenic mechanisms underlying the development of MI in the younger. Young patients with M...
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#1Batool Almogheer (Harefield Hospital)
#2Alexios S. Antonopoulos (UoA: National and Kapodistrian University of Athens)H-Index: 30
Last. Raad H. Mohiaddin (NIH: National Institutes of Health)H-Index: 63
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Neuromuscular diseases (NMD) encompass a broad spectrum of diseases with variable type of cardiac involvement and there is lack of clinical data on Cardiovascular Magnetic Resonance (CMR) phenotypes or even prognostic value of CMR in NMD. We explored the diagnostic and prognostic value of CMR in NMD-related cardiomyopathies. The study included retrospective analysis of a cohort of 111 patients with various forms of NMD; mitochondrial: n = 14, Friedreich’s ataxia (FA): n = 27, myotonic dystrophy:...
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#1George Lazaros (UoA: National and Kapodistrian University of Athens)H-Index: 24
#2Emilia Lazarou (UoA: National and Kapodistrian University of Athens)H-Index: 6
Last. Konstantinos Tsioufis (UoA: National and Kapodistrian University of Athens)H-Index: 26
view all 5 authors...
The main pericardial syndromes include acute and recurrent pericarditis, constrictive pericarditis and chronic pericardial effusion in the absence of overt inflammation. Despite recent advances in pericardial syndromes, certain clinical scenarios depict remarkable peculiarities and their management is often challenging for the clinician. Acute pericarditis is the most common pericardial disease and in most instances is accompanied by pericardial effusion. On the other hand, pericardial effusion ...
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Aims null Recent clinical trials indicate that sodium-glucose cotransporter 2 (SGLT2) inhibitors improve cardiovascular outcomes in heart failure patients, but the underlying mechanisms remain unknown. We explored the direct effects of canagliflozin, an SGLT2 inhibitor with mild SGLT1 inhibitory effects, on myocardial redox signalling in humans. null Methods and results null Study 1 included 364 patients undergoing cardiac surgery. Right atrial appendage biopsies were harvested to quantify super...
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