Carol L. K. Sabourin
Battelle Memorial Institute
GeneInternal medicinePathologyGene expressionMolecular biologyVirologyAntibodyImmunologyVirusInflammationDermisAnthrax Vaccine AdsorbedSulfur mustardImmunoglobulin GMonodelphis domesticaCell cycleCancer researchCarcinogenesisMedicineBiologyImmune systemPharmacology
Publications 68
#1Nancy A. Niemuth (Battelle Memorial Institute)H-Index: 13
#2Thomas L. Rudge (Battelle Memorial Institute)H-Index: 11
Last. Carol L. K. Sabourin (Battelle Memorial Institute)H-Index: 24
view all 7 authors...
An anti-Zaire Ebola virus (EBOV) glycoprotein (GP) immunoglobulin G (IgG) enzyme linked immunosorbent assay (ELISA) was developed to quantify the serum levels of anti-EBOV IgG in human and non-human primate (NHP) serum following vaccination and/or exposure to EBOV. This method was validated for testing human serum samples as previously reported. However, for direct immunobridging comparability between humans and NHPs, additional testing was warranted. First, method feasibility experiments were p...
#1Michael S. Anderson (Battelle Memorial Institute)H-Index: 6
#2Nancy A. Niemuth (Battelle Memorial Institute)H-Index: 13
Last. Thomas L. Rudge (Battelle Memorial Institute)H-Index: 11
view all 6 authors...
The need for an efficacious vaccine against highly pathogenic filoviruses was reinforced by the devastating 2014-2016 outbreak of Ebola virus (EBOV) disease (EVD) in Guinea, Sierra Leone, and Liberia that resulted in over 28,000 cases and over 11,300 deaths. In addition, the 2018-2020 outbreak in the Democratic Republic of the Congo currently has over 3,400 cases and over 2,200 deaths. A fully licensed vaccine and at least one other investigational vaccine are being deployed to combat this EVD o...
#1Kevin G. McGarry (Battelle Memorial Institute)H-Index: 5
#2Kevin E Schill (Battelle Memorial Institute)H-Index: 1
Last. Robert A. Moyer (Battelle Memorial Institute)H-Index: 4
view all 7 authors...
Organophosphorus (OP) compounds, which include insecticides and chemical warfare nerve agents (CWNAs) such as sarin (GB) and VX, continue to be a global threat to both civilian and military populations. It is widely accepted that cholinesterase inhibition is the primary mechanism for acute OP toxicity. Disruption of cholinergic function through the inhibition of acetylcholinesterase (AChE) leads to the accumulation of the neurotransmitter acetylcholine. Excess acetylcholine at the synapse result...
#1Janice M. RusnakH-Index: 3
#2Pamela J. Glass (USAMRIID: United States Army Medical Research Institute of Infectious Diseases)H-Index: 20
Last. Lucy A. WardH-Index: 6
view all 9 authors...
Licensure of a vaccine to protect against aerosolized Venezuelan equine encephalitis virus (VEEV) requires use of the U.S. Food and Drug Administration (FDA) Animal Rule to assess vaccine efficacy as human studies are not feasible or ethical. An approach to selecting VEEV challenge strains for use under the Animal Rule was developed, taking into account Department of Defense (DOD) vaccine requirements, FDA Animal Rule guidelines, strain availability, and lessons learned from the generation of fi...
#1Thomas L. Rudge (Battelle Memorial Institute)H-Index: 11
#2Karen A. Sankovich (Battelle Memorial Institute)H-Index: 2
Last. Carol L. K. Sabourin (Battelle Memorial Institute)H-Index: 24
view all 8 authors...
The need for an efficacious vaccine against highly pathogenic filoviruses was reinforced by the recent and devastating 2014–2016 outbreak of Ebola virus (EBOV) disease in Guinea, Sierra Leone, and Liberia that resulted in more than 10,000 casualties. Such a vaccine would need to be vetted through a U.S. Food and Drug Administration (FDA) traditional, accelerated, or Animal Rule or similar European Medicines Agency (EMA) regulatory pathway. Under the FDA Animal Rule, vaccine-induced immune respon...
#1Demetrius MatassovH-Index: 10
#2Chad E. MireH-Index: 33
Last. John H. EldridgeH-Index: 54
view all 16 authors...
Previous studies demonstrated that a single intramuscular (i.m.) dose of an attenuated recombinant vesicular stomatitis virus (rVSV) vector (VesiculoVax vector platform; rVSV-N4CT1) expressing the glycoprotein (GP) from the Mayinga strain of Zaire ebolavirus (EBOV) protected nonhuman primates (NHPs) from lethal challenge with EBOV strains Kikwit and Makona. Here, we studied the immunogenicities of an expanded range of attenuated rVSV vectors expressing filovirus GP in mice. Based on data from th...
#1Beth A. Reed (Battelle Memorial Institute)H-Index: 1
#2Carol L. K. Sabourin (Battelle Memorial Institute)H-Index: 24
Last. David E. LenzH-Index: 30
view all 3 authors...
: Acetylcholinesterase is vital for normal operation of many processes in the body. Following exposure to organophosphorus (OP) nerve agents, death can ensue without immediate medical intervention. Current therapies mitigate the cholinergic crisis caused by nerve agents but do not fully prevent long-term health concerns, for example, brain damage following seizures. Human butyrylcholinesterase (HuBChE) is a stoichiometric bioscavenger being investigated as an antidote for OP nerve agent poisonin...
#1Patrick J. Sabourin (Battelle Memorial Institute)H-Index: 8
#2Christina L. Kobs (Battelle Memorial Institute)H-Index: 2
Last. Edgar J. WakayamaH-Index: 1
view all 8 authors...
Potassium cyanide (KCN) is an inhibitor of cytochrome C oxidase causing rapid death due to hypoxia. A well-characterized model of oral KCN intoxication is needed to test new therapeutics under the Food and Drug Administration Animal Rule. Clinical signs, plasma pH and lactate concentrations, biomarkers, histopathology, and cyanide and thiocyanate toxicokinetics were used to characterize the pathology of KCN intoxication in adult and juvenile mice. The acute oral LD50s were determined to be 11.8,...
ABSTRACT Protective antigen (PA)-specific antibody and cell-mediated immune (CMI) responses to annual and alternate booster schedules of anthrax vaccine adsorbed (AVA; BioThrax) were characterized in humans over 43 months. Study participants received 1 of 6 vaccination schedules: a 3-dose intramuscular (IM) priming series (0, 1, and 6 months) with a single booster at 42 months (4-IM); 3-dose IM priming with boosters at 18 and 42 months (5-IM); 3-dose IM priming with boosters at 12, 18, 30, and 4...
#1John C. TrefryH-Index: 12
#2Suzanne E WollenH-Index: 9
Last. M. Louise M. Pitt (Battelle Memorial Institute)H-Index: 17
view all 17 authors...
Recent experimentation with the variants of the Ebola virus that differ in the glycoprotein’s poly-uridine site, which dictates the form of glycoprotein produced through a transcriptional stutter, has resulted in questions regarding the pathogenicity and lethality of the stocks used to develop products currently undergoing human clinical trials to combat the disease. In order to address these concerns and prevent the delay of these critical research programs, we designed an experiment that permi...
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