Pierluigi Paggiaro
University of Pisa
AirwayInternal medicinePhysical therapyPediatricsImmunologyPlaceboAsthmaBronchial hyperresponsivenessSputumSalmeterolCOPDInhalationExacerbationFormoterolMethacholineIn patientAnesthesiaMedicinePulmonary function testingGastroenterology
Publications 451
#1Maria Laura Bartoli (UniPi: University of Pisa)H-Index: 14
#2Manuela LatorreH-Index: 13
Last. Pierluigi Paggiaro (UniPi: University of Pisa)H-Index: 55
view all 8 authors...
Sputum eosinophilia in Chronic Obstructive Pulmonary Disease (COPD) patients seems to be associated with a better response to inhaled corticosteroids (ICS). To verify if this feature could identify a specific subpopulation of COPD patients, we retrospectively compared functional and inflammatory parameters of 110 COPD patients according to the presence of sputum eosinophilia (>2%). Patient with eosinophilia were characterized by lower dyspnea score, lower functional impairment and lower ICS use,...
#8Manuel G. Cosio (UNIPD: University of Padua)H-Index: 7
Chronic obstructive pulmonary disease (COPD) is a complex condition in which systemic inflammation plays a role in extrapulmonary manifestations, including cardiovascular diseases: interleukin (IL)-6 has a role in both COPD and atherogenesis. The 2011 GOLD document classified patients according to FEV1, symptoms, and exacerbations history, creating four groups, from A (less symptoms/low risk) to D (more symptoms/high risk). Extracellular vesicles (EV) represent potential markers in COPD: neverth...
#1William W. Busse (UW: University of Wisconsin-Madison)H-Index: 138
#2Pierluigi Paggiaro (UniPi: University of Pisa)H-Index: 55
Last. Benjamin Ortiz (Regeneron)H-Index: 1
view all 11 authors...
Severe asthma affects an estimated 5–10% of the total asthma patient population [1]. Various demographic factors, such as sex, age, obesity, and age of onset, have been associated with asthma disease severity [2, 3], and the efficacy of asthma treatments has previously been found to vary depending on patient demographics [4, 5]. Footnotes This manuscript has recently been accepted for publication in the European Respiratory Journal . It is published here in its accepted form prior to copyediting...
#1Fulvio Braido (UniGe: University of Genoa)H-Index: 33
#2Francesco Blasi (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 125
Last. Manlio MilaneseH-Index: 22
view all 13 authors...
The prevalence of asthma in Italy is estimated to be around 4%; it affects approximately 2,000,000 citizens, and up to 80–90% of patients have mild-to-moderate asthma. Despite the clinical relevanc...
Background Asthma is a chronic disease characterized by airway hyperresponsiveness, inflammation and mucus production. In Type 2 asthma, two phenotypic components are often co-expressed (eosinophilic and allergic). Elevated biomarker levels, such as eosinophils (EOS), fraction of exhaled nitric oxide (FeNO) and immunoglobulin E (IgE), are key clinical indicators of Type 2 inflammation. Dupilumab has been recently approved for the treatment of uncontrolled severe Type 2 asthma. Type 2 asthma incl...
#1Alessandro Celi (UniPi: University of Pisa)H-Index: 25
#2Manuela Latorre (UniPi: University of Pisa)H-Index: 13
Last. Riccardo Pistelli (CUA: The Catholic University of America)H-Index: 28
view all 4 authors...
Chronic obstructive pulmonary disease (COPD) has a 3-year mortality rate up to 37%, 2-6 times higher than the general population. We present evidence supporting pharmacological therapies to improve patient life expectancy, focusing on inhaled corticosteroids (ICSs) combined with long-acting bronchodilators (LABDs). A reduction in 3-year all-cause mortality (ACM) has been shown in patients with severe COPD treated with fluticasone propionate (an ICS) and salmeterol [long-acting beta-agonist (LABA...
#1Pierluigi Paggiaro (UniPi: University of Pisa)H-Index: 55
Last. Giorgio Walter Canonica (Humanitas University)H-Index: 104
view all 12 authors...
Introduction People with severe asthma (SA) often have poor disease control and quality of life, and are at high risk of exacerbations, lung function decline and asthma-related death. The present expert opinion article aimed to identify unmet needs in the management of SA in Italy, and propose possible solutions to address these needs. Methods At five multidisciplinary events in Italy, attendees identified factors that interfered with the effective management of SA and suggested how these barrie...
#1Paolo Solidoro (UNITO: University of Turin)H-Index: 22
#2Stefania Nicola (UNITO: University of Turin)H-Index: 5
Last. Luisa Brussino (UNITO: University of Turin)H-Index: 23
view all 11 authors...
#1Giacomo MalipieroH-Index: 8
#2Giovanni Paoletti (Humanitas University)H-Index: 10
Last. Enrico Heffler (Humanitas University)H-Index: 32
view all 13 authors...
Several severe asthma comorbidities have been identified: an emerging one is bronchiectasis. We evaluated the frequency of bronchiectasis on severe asthma in a real-life setting, through the ‘Sever...
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