Ilja L. Kruglikov
PathophysiologyAdipogenesisDownregulation and upregulationEndocrinologyWhite adipose tissueAdipose tissueChemistryMaterials scienceImmunologyAdipocyteInflammationHair follicleHuman skinDermisCaveolinPsoriasisCaveolin 1Skin AgingMedicineCell biology
28Publications
13H-index
486Citations
Publications 28
Newest
#1Ilja L. KruglikovH-Index: 13
#2Philipp E. Scherer (UTSW: University of Texas Southwestern Medical Center)H-Index: 149
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#1Zhuzhen Zhang (UTSW: University of Texas Southwestern Medical Center)H-Index: 18
#2Ilja L. KruglikovH-Index: 13
Last. Philipp E. Scherer (UTSW: University of Texas Southwestern Medical Center)H-Index: 149
view all 10 authors...
Dermal fibroblasts are an essential population of skin cells. They are not only responsible for synthesis and remodelling of the extracellular matrix of the dermis, but also communicate with other skin cells via autocrine and paracrine interactions. Skin-associated dermal adipocytes reside below the reticular dermis. Strong lipolysis is observed during the regression of dermal adipocytes. However, the nature of the local intercellular crosstalk in which lipids released by dermal adipocytes affec...
3 CitationsSource
Reciprocal interaction between electrical and mechanical waves observed in axonal membrane during its excitation leads to a paradigm shift in pain research making the uncoupling of electro-mechanical signals an interesting target in pain treatment. This uncoupling can be realized either through direct disturbance of the mechanical surface waves in axonal membrane or through shifting of the thermodynamic state of this membrane far from its phase transition point. Both effects can be effectively r...
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#1Ilja L. KruglikovH-Index: 13
#2Manasi Sanjiv Shah (UTSW: University of Texas Southwestern Medical Center)H-Index: 1
Last. Philipp E. Scherer (UTSW: University of Texas Southwestern Medical Center)H-Index: 149
view all 3 authors...
Obesity and diabetes are established comorbidities for COVID-19. Adipose tissue demonstrates high expression of ACE2 which SARS- CoV-2 exploits to enter host cells. This makes adipose tissue a reservoir for SARS-CoV-2 viruses and thus increases the integral viral load. Acute viral infection results in ACE2 downregulation. This relative deficiency can lead to disturbances in other systems controlled by ACE2, including the renin-angiotensin system. This will be further increased in the case of pre...
18 CitationsSource
#1Ilja L. KruglikovH-Index: 13
#2Nolwenn Joffin (UTSW: University of Texas Southwestern Medical Center)H-Index: 9
Last. Philipp E. Scherer (UTSW: University of Texas Southwestern Medical Center)H-Index: 149
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Lipoedema is associated with widespread adipose tissue expansion, particularly in the proximal extremities. The mechanisms that drive the development of lipoedema are unclear. In this Perspective article, we propose a new model for the pathophysiology of lipoedema. We suggest that lipoedema is an oestrogen-dependent disorder of adipose tissue, which is triggered by a dysfunction of caveolin 1 (CAV1) and subsequent uncoupling of feedback mechanisms between CAV1, the matrix metalloproteinase MMP14...
3 CitationsSource
#1Ilja L. KruglikovH-Index: 13
#2Philipp E. Scherer (UTSW: University of Texas Southwestern Medical Center)H-Index: 149
Abstract Coronavirus disease-2019 (COVID-19), caused by the highly pathogenic virus SARS-CoV-2, demonstrates high morbidity and mortality caused by development of a severe acute respiratory syndrome connected with extensive pulmonary fibrosis (PF). In this Perspective, we argue that adipocytes and adipocyte-like cells, such as pulmonary lipofibroblasts, may play an important role in the pathogenic response to COVID-19. Expression of angiotensin-converting enzyme 2 (ACE2 - the functional receptor...
87 CitationsSource
#1Ilja L. KruglikovH-Index: 13
#2Philipp E. Scherer (UTSW: University of Texas Southwestern Medical Center)H-Index: 149
Expression of caveolin-1 (Cav-1) is an important pathophysiological factor in acne. Cav-1 strongly interacts with such well-recognized etiopathogenic factors such as hyperseborrhea, follicular hyperkeratinization and pathogenicity of Cutibacterium acnes. Cav-1 is a strong negative regulator of transforming growth factor beta (TGF-beta) expression. It acts as a critical determinant of autophagy, which is significantly induced in acne lesions through C. acnes and by absorption of fatty acids. Cav-...
5 CitationsSource
#1Ilja L. KruglikovH-Index: 13
#2Philipp E. Scherer (UTSW: University of Texas Southwestern Medical Center)H-Index: 149
Caveolin-1 is strongly expressed in different dermal and subdermal cells and physically interacts with signaling molecules and receptors, among them with transforming growth factor beta (TGF-β), matrix metalloproteinases, heat shock proteins, toll-like and glucocorticoid receptors. It should therefore be heavily involved in the regulation of cellular signaling in various hyperproliferative and inflammatory skin conditions. We provide an overview of the role of the caveolin-1 expression in differ...
3 CitationsSource
#1Zhuzhen ZhangH-Index: 18
#2Mengle ShaoH-Index: 25
Last. Philipp E. SchererH-Index: 149
view all 25 authors...
: Dermal adipose tissue (also known as dermal white adipose tissue and herein referred to as dWAT) has been the focus of much discussion in recent years. However, dWAT remains poorly characterized. The fate of the mature dermal adipocytes and the origin of the rapidly reappearing dermal adipocytes at different stages remain unclear. Here, we isolated dermal adipocytes and characterized dermal fat at the cellular and molecular level. Together with dWAT's dynamic responses to external stimuli, we ...
39 CitationsSource
#1Ilja L. KruglikovH-Index: 13
#2Zhuzhen Zhang (UTSW: University of Texas Southwestern Medical Center)H-Index: 18
Last. Philipp E. Scherer (UTSW: University of Texas Southwestern Medical Center)H-Index: 149
view all 3 authors...
Abstract Caveolin-1 (Cav-1) appears to be both a pathophysiological contributor and a target in different inflammatory and hyperproliferative skin conditions as well as in skin aging. Skin fibroblasts demonstrate an up-regulation of Cav-1 expression both in chronological and UV-induced aging, and such an up-regulation was observed both in vitro and in vivo. Typical alterations in aging skin involve a reduction of the dermis thickness, a significant expansion of the dermal white adipose tissue as...
12 CitationsSource