Yahya E. Choonara
University of the Witwatersrand
Self-healing hydrogelsTargeted drug deliveryBiomedical engineeringNanoparticleControlled releaseNanotechnologyBioavailabilityChemistryPolymer chemistryMaterials scienceIn vivoChitosanDrug deliveryDrugChemical engineeringChromatographyPolymerMedicineZeta potentialPharmacology
366Publications
34H-index
5,364Citations
Publications 335
Newest
#1Fadzai P. Mutingwende (University of the Witwatersrand)
#2Pierre P. D. Kondiah (University of the Witwatersrand)H-Index: 13
Last. Yahya E. Choonara (University of the Witwatersrand)H-Index: 34
view all 5 authors...
Nanotechnology has aided in the advancement of drug delivery for the treatment of several neurological disorders including depression. Depression is a relatively common mental disorder which is characterized by a severe imbalance of neurotransmitters. Several current therapeutic regimens against depression display drawbacks which include low bioavailability, delayed therapeutic outcome, undesirable side effects and drug toxicity due to high doses. The blood-brain barrier limits the entry of the ...
Source
#1Courtney R Lynch (University of the Witwatersrand)H-Index: 2
#2Pierre P. D. Kondiah (University of the Witwatersrand)H-Index: 13
Last. Yahya E. Choonara (University of the Witwatersrand)H-Index: 34
view all 3 authors...
Tissue engineering is known to encompass multiple aspects of science, medicine and engineering. The development of systems which are able to promote the growth of new cells and tissue components are vital in the treatment of severe tissue injury and damage. This can be done through a variety of different biofabrication strategies including the use of hydrogels, 3D bioprinted scaffolds and nanotechnology. The incorporation of stem cells into these systems and the advantage of this is also discuss...
Source
#1Tayo Alex Adekiya (University of the Witwatersrand)H-Index: 5
#2Pradeep Kumar (University of the Witwatersrand)H-Index: 31
Last. Yahya E. Choonara (University of the Witwatersrand)H-Index: 34
view all 5 authors...
INTRODUCTION : Among all the anti-schistosomal drug, praziquantel has been the most widely used. However, some major challenges have been faced using the drug in the treatment of schistosome infections. AREAS COVERED : Several approaches used in the synthesis of praziquantel aimed at reducing the time and cost of production, the toxicity and experimental harsh conditions are discussed. Also, patented methods involved in the pharmaceutical reformulation of praziquantel in the treatment of diverse...
Source
The demand for biodegradable sustained release carriers with minimally invasive and less frequent administration properties for therapeutic proteins and peptides has increased over the years. The purpose of achieving sustained minimally invasive and site-specific delivery of macromolecules led to the investigation of a photo-responsive delivery system. This research explored a biodegradable prolamin, zein, modified with an azo dye (DHAB) to synthesize photo-responsive azoprolamin (AZP) nanospher...
Source
#1Thashree Marimuthu (University of the Witwatersrand)H-Index: 11
#2Pradeep Kumar (University of the Witwatersrand)H-Index: 31
Last. Yahya E. Choonara (University of the Witwatersrand)H-Index: 34
view all 3 authors...
INTRODUCTION : Water soluble polysaccharides are versatile structural materials that can be used for the design of biocompatible hydrogels and wet dressings in wound healing applications. Glycol chitosan (GC) is an example of a multifunctional water-soluble chitosan derivative that has inherent wound healing properties and reactive sites for chemical modification. AREAS COVERED : United States (US) patent US2019202998A1 describes the preparation of a novel wound healing technology based on a thr...
Source
#1Kara M de la Harpe (University of the Witwatersrand)H-Index: 1
#2Pierre P. D. Kondiah (University of the Witwatersrand)H-Index: 13
Last. Yahya E. Choonara (University of the Witwatersrand)H-Index: 34
view all 4 authors...
Abstract Suture materials constitute one of the largest biomedical material groups with a huge global market of $ 1.3 billion annually and employment in over 12 million procedures per year. Suture materials have radically evolved over the years, from basic strips of linen to more advanced synthetic polymer sutures. Yet, the journey to the ideal suture material is far from over and we now stand on the brink of a new era of improved suture materials with greater safety and efficacy. This next step...
Source
#1Pradeep Kumar (University of the Witwatersrand)H-Index: 31
#2Viness Pillay (University of the Witwatersrand)H-Index: 38
Last. Yahya E. Choonara (University of the Witwatersrand)H-Index: 34
view all 3 authors...
Three-dimensional porous scaffolds are widely employed in tissue engineering and regenerative medicine for their ability to carry bioactives and cells; and for their platform properties to allow for bridging-the-gap within an injured tissue. This study describes the effect of various methoxypolyethylene glycol (mPEG) derivatives (mPEG (-OCH3 functionality), mPEG-aldehyde (mPEG-CHO) and mPEG-acetic acid (mPEG-COOH)) on the morphology and physical properties of chemically crosslinked, semi-interpe...
Source
#1Sarah M Kola (University of the Witwatersrand)H-Index: 1
#2Yahya E. Choonara (University of the Witwatersrand)H-Index: 34
Last. Viness Pillay (University of the Witwatersrand)H-Index: 38
view all 5 authors...
Recent research has been successful in demonstrating the importance of the addition of platelets to the field of cell-mediated therapeutics, by making use of different platelet forms to design modalities able to positively impact a wide range of diseases. A key obstacle hindering the success of conventional therapeutic interventions is their inability to produce targeted treatment, resulting in a number of systemic side effects and a longer duration for the onset of action to occur. An additiona...
2 CitationsSource
#1Lisa C. du ToitH-Index: 34
#2Yahya E. ChoonaraH-Index: 34
Last. Viness PillayH-Index: 38
view all 3 authors...
This investigation focused on the design of an injectable nano-enabled thermogel (nano-thermogel) system to attain controlled delivery of p11 anti-angiogenic peptide for proposed effective prevention of neovascularisation and to overcome the drawbacks of the existing treatment approaches for ocular disorders characterised by angiogenesis, which employ multiple intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) antibodies. Synthesis of a polyethylene glycol-polycaprola...
Source
#1Onyinye J. Uwaezuoke (University of the Witwatersrand)
#2Pradeep Kumar (University of the Witwatersrand)H-Index: 31
Last. Yahya E. Choonara (University of the Witwatersrand)H-Index: 34
view all 4 authors...
The last 30 years has seen a proliferation of research on protein-resistant biomaterials targeted at designing bio-inert surfaces, which are prerequisite for optimal performance of implantable devices that contact biological fluids and tissues. These efforts have only been able to yield minimal results, and hence, the ideal anti-fouling biomaterial has remained elusive. Some studies have yielded biomaterials with a reduced fouling index among which high molecular weight polyethylene glycols have...
Source