Emilie T. Reas
University of California, San Diego
Association (psychology)Hippocampal formationPsychologyNeuroscienceCognitionCognitive psychologyLong-term memoryDiseaseDementiaTemporal lobeHippocampusWhite matterCognitive declineCognitive agingSpatial memoryRisk factorApolipoprotein ECognitive reserveMedicineGerontologyEpisodic memoryVerbal fluency test
Publications 28
#1Emilie T. Reas (UCSD: University of California, San Diego)H-Index: 13
#2Gail A. Laughlin (UCSD: University of California, San Diego)H-Index: 65
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
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BACKGROUND: Evidence suggests that moderate alcohol consumption may protect against cognitive decline and dementia. However, uncertainty remains over the patterns of drinking that are most beneficial. OBJECTIVE: To examine associations between amount and frequency of alcohol consumption with multiple domains of cognitive function in a well-characterized cohort of older community-dwelling adults in southern California. DESIGN: Observational, cross-sectional cohort study. SETTING: A research visit...
15 CitationsSource
#1Emilie T. Reas (UCSD: University of California, San Diego)H-Index: 13
#2James B. Brewer (UCSD: University of California, San Diego)H-Index: 50
Introduction The medial temporal lobe supports integrating the “what,” “where,” and “when” of an experience into a unified memory. However, it remains unclear how representations of these contextual features are neurally encoded and distributed across medial temporal lobe subregions. Methods This study conducted functional magnetic resonance imaging of the medial temporal lobe, while participants retrieved pair, spatial, and temporal source memories. Multivoxel classifiers were trained to distin...
1 CitationsSource
#1Stephanie A. Carmack (UCSD: University of California, San Diego)H-Index: 9
#2Kristin K. Howell (UCSD: University of California, San Diego)H-Index: 4
Last. Stephan G. Anagnostaras (UCSD: University of California, San Diego)H-Index: 31
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.Methylphenidate (MPH), introduced more than 60 years ago, accounts for two-thirds of current prescriptions for attention deficit hyperactivity disorder (ADHD). Although many studies have modeled MPH’s effect on executive function, almost none have directly modeled its effect on long-term memory (LTM), even though improvement in LTM is a critical target of therapeutic intervention in ADHD. We examined the effects of a wide range of doses of MPH (0.01–10 mg/kg, i.p.) on Pavlovian fear learning, a...
25 CitationsSource
#1Emilie T. ReasH-Index: 13
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Functional neuroimaging studies have demonstrated activation of the brain's medial temporal lobe during episodic memory retrieval. However, inconsistent evidence from lesion studies indicate that, although the medial temporal lobe is essential for acquiring new declarative memories, it may not be critical for all forms of retrieval. Given the multitude of mnemonic and non- mnemonic processes invoked during a guided retrieval episode, including attending to memory cues, searching through a memory...
Functional neuroimaging studies have increasingly noted hippocampal activation associated with a variety of cognitive functions such as decision-making, attention, perception, incidental learning, prediction and working memory, which have little apparent relation to declarative memory. Such findings might be difficult to reconcile with classical hippocampal lesion studies that show remarkable sparing of cognitive functions outside the realm of declarative memory. Even the oft-reported hippocampa...
4 CitationsSource
#1Emilie T. Reas (UCSD: University of California, San Diego)H-Index: 13
#2James B. Brewer (UCSD: University of California, San Diego)H-Index: 50
Functional imaging studies frequently report that the hippocampus is engaged by successful episodic memory retrieval. However, considering that concurrent encoding of the background environment occurs during retrieval and influences medial temporal lobe activity, it is plausible that hippocampal encoding functions are reduced with increased attentional engagement during effortful retrieval. Expanding upon evidence that retrieval efforts suppress activity in hippocampal regions implicated in enco...
10 CitationsSource
Neuroimaging studies of episodic memory retrieval have revealed activations in the human frontal, parietal, and medial-temporal lobes that are associated with memory strength. However, it remains unclear whether these brain responses are veritable signals of memory strength or are instead regulated by concomitant subcomponents of retrieval such as retrieval effort or mental search. This study used event-related fMRI during cued recall of previously memorized word-pair associates to dissociate br...
15 CitationsSource
#1Emilie T. Reas (UCSD: University of California, San Diego)H-Index: 13
#2Sarah I. Gimbel (UCSD: University of California, San Diego)H-Index: 5
Last. James B. Brewer (UCSD: University of California, San Diego)H-Index: 50
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Episodic memory retrieval involves the coordinated interaction of several cognitive processing stages such as mental search, access to a memory store, associative re-encoding, and post-retrieval monitoring. The neural response during memory retrieval is an integration of signals from multiple regions that may subserve supportive cognitive control, attention, sensory association, encoding, or working memory functions. It is particularly challenging to dissociate contributions of these distinct co...
13 CitationsSource