Emilie T. Reas
University of California, San Diego
Association (psychology)Hippocampal formationPsychologyNeuroscienceCognitionCognitive psychologyLong-term memoryDiseaseDementiaTemporal lobeHippocampusWhite matterCognitive declineCognitive agingSpatial memoryRisk factorApolipoprotein ECognitive reserveMedicineGerontologyEpisodic memoryVerbal fluency test
29Publications
13H-index
262Citations
Publications 29
Newest
#1Sarah J. Banks (UCSD: University of California, San Diego)H-Index: 21
#2Murray J. Andrews (UCSD: University of California, San Diego)H-Index: 2
Last. James B. Brewer (UCSD: University of California, San Diego)H-Index: 50
view all 10 authors...
Abstract null null To determine if sex differences in verbal memory in AD are related to differences in extent or distribution of pathological tau, we studied 275 participants who were amyloid PET positive and carried clinical classifications of normal cognition, mild cognitive impairment (MCI) or dementia, and had tau (AV1451) PET. We compared tau distribution between men and women, and as a function of genetic risk. In MCI we further explored the relationship between quantity and distribution ...
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#1Emilie T. Reas (UCSD: University of California, San Diego)H-Index: 13
#2Gail A. Laughlin (UCSD: University of California, San Diego)H-Index: 65
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
view all 6 authors...
Midlife vascular disease increases risk for dementia and effects of vascular dysfunction on brain health differ between men and women. Elevated pulse pressure, a surrogate for arterial stiffness, contributes to cerebrovascular pathology and white matter damage that may advance cognitive aging; however, it remains unclear how associations between pulse pressure and neural integrity differ by sex and age. This study used restriction spectrum imaging to examine associations between pulse pressure a...
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#1Emilie T. Reas (UCSD: University of California, San Diego)H-Index: 13
#2Donald J. Hagler (UCSD: University of California, San Diego)H-Index: 88
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
view all 6 authors...
Normal brain aging is characterized by declining neuronal integrity, yet it remains unclear how microstructural injury influences cognitive aging and whether such mechanisms differ between sexes. Using restriction spectrum imaging (RSI), we examined sex differences in associations between brain microstructure and cognitive function in 147 community-dwelling older men and women (56-99 years). Gray and white matter microstructure correlated with global cognition, executive function, visuospatial m...
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#1Emilie T. Reas (UCSD: University of California, San Diego)H-Index: 13
#2Donald J. Hagler (UCSD: University of California, San Diego)H-Index: 88
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
view all 5 authors...
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#1Emilie T. Reas (UCSD: University of California, San Diego)H-Index: 13
#2Donald J. Hagler (UCSD: University of California, San Diego)H-Index: 88
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
view all 6 authors...
Abstract Cytoarchitectural brain changes within gray matter and fiber tracts during normal aging remain poorly characterized, and it is unclear whether rates and patterns of brain aging differ by sex. This study used restriction spectrum imaging (RSI) to examine associations between age and brain microstructure in 147 community-dwelling participants (aged 56-99). Widespread associations with older age in multiple diffusion compartments, including increased free water, decreased restricted and hi...
2 CitationsSource
#1Ali Al-Attar (UCSD: University of California, San Diego)H-Index: 16
#2Jaclyn Bergstrom (UCSD: University of California, San Diego)H-Index: 23
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
view all 9 authors...
Background: Hearing impairment is prevalent among older adults and has been identified as a risk factor for cognitive impairment and dementia. We evaluated the association of hearing impairment with long-term cognitive decline among community-dwelling older adults. Methods: A population-based longitudinal study of adults not using hearing aids who had hearing acuity and cognitive function assessed in 1992-96, and were followed for a maximum of 24 years with up to five additional cognitive assess...
21 CitationsSource
#1Emilie T. Reas (UCSD: University of California, San Diego)H-Index: 13
#2Donald J. Hagler (UCSD: University of California, San Diego)H-Index: 88
Last. James B. Brewer (UCSD: University of California, San Diego)H-Index: 50
view all 10 authors...
BACKGROUND: Although amyloid-beta (Abeta) and microstructural brain changes are both effective biomarkers of Alzheimer's disease, their independent or synergistic effects on cognitive decline are unclear. OBJECTIVE: To examine associations of Abeta and brain microstructure with cognitive decline in amnestic mild cognitive impairment and dementia. METHODS: Restriction spectrum imaging, cerebrospinal fluid Abeta, and longitudinal cognitive data were collected on 23 healthy controls and 13 individu...
4 CitationsSource
#1Min-Tzu Lo (UCSD: University of California, San Diego)H-Index: 14
#2Karolina Kauppi (UCSD: University of California, San Diego)H-Index: 17
Last. Chi-Hua Chen (UCSD: University of California, San Diego)H-Index: 34
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Abstract The risk of APOE for Alzheimer's disease (AD) is modified by age. Beyond APOE, the polygenic architecture may also be heterogeneous across age. We aim to investigate age-related genetic heterogeneity of AD and identify genomic loci with differential effects across age. Stratified gene-based genome-wide association studies and polygenic variation analyses were performed in the younger (60–79 years, N = 14,895) and older (≥80 years, N = 6559) age-at-onset groups using Alzheimer's Disease ...
14 CitationsSource
#1Leonardino A. Digma (UCSD: University of California, San Diego)H-Index: 2
#2John Madsen (UCSD: University of California, San Diego)H-Index: 2
Last. Sarah J. Banks (UCSD: University of California, San Diego)H-Index: 21
view all 7 authors...
Background Late-onset Alzheimer’s disease (AD) is characterized by primary memory impairment, which then progresses towards severe deficits across cognitive domains. Here, we report how performance in cognitive domains relates to patterns of tau deposition and cortical thickness.
13 CitationsSource
#1Sarah J. Banks (UCSD: University of California, San Diego)H-Index: 21
#2Leonardino A. Digma (UCSD: University of California, San Diego)H-Index: 2
Last. James B. Brewer (UCSD: University of California, San Diego)H-Index: 50
view all 9 authors...
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