Mónica H. Vazquez-Levin
Instituto de Biología y Medicina Experimental
Internal medicineEndocrinologyCadherinMolecular biologyAntibodyAndrologyImmunologyZona pellucidaOocyteAcrosinSperm motilityInfertilitySemenAcrosome reactionCapacitationSpermMedicineBiologyHuman fertilizationCell biology
67Publications
21H-index
1,208Citations
Publications 67
Newest
BACKGROUND Androgen deficiency affects men in the adulthood, causing several harmful effects at the reproductive and behavioural levels. Since aromatase is an enzyme that catalyses the conversion of androgens to estrogens, and it is responsible for an adequate balance of both sex hormones in males and females, the administration of molecules acting as down modulators may contribute to restore an abnormal enzymatic activity. A prospective pilot study was carried out to investigate the effect of D...
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#1Gustavo Luis Verón (Instituto de Biología y Medicina Experimental)H-Index: 3
#2Andrea TisseraH-Index: 10
Last. Mónica H. Vazquez-Levin (Instituto de Biología y Medicina Experimental)H-Index: 21
view all 8 authors...
Spermatogenesis is a temperature-dependent process, and high summer temperatures have been linked to lower sperm concentration and count. However, reports describing the association between other meteorological variables and semen quality are scarce. This study evaluated the association between semen quality and temperature, humidity, pressure, apparent temperature (AT), temperature-humidity index (THI), simplified wet-bulb global temperature (sWBGT), and sunshine duration. Semen samples were ob...
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#1Fabio Facchinetti (University of Modena and Reggio Emilia)H-Index: 73
#2Maria Salome Bezerra Espinola (Sapienza University of Rome)H-Index: 5
Last. Annarita StringaroH-Index: 33
view all 30 authors...
It is well known that myo-inositol (MI) and D-chiro-inositol (DCI) are insulin-sensitizing agents, and MI is of proven utility in polycystic ovary syndrome (PCOS). In addition, MI plays a pivotal role in the physiology of reproduction, and has beneficial effects on the development of oocytes, spermatozoa, and embryos. By contrast, DCI has little effect on spermatozoa, but high concentrations in the ovary can negatively affect the quality of oocytes and the blastocyst. Overall, the evidence in th...
10 CitationsSource
#1María Victoria Mencucci (Instituto de Biología y Medicina Experimental)H-Index: 2
#2Lara Lapyckyj (Instituto de Biología y Medicina Experimental)H-Index: 6
Last. Mónica H. Vazquez-Levin (Instituto de Biología y Medicina Experimental)H-Index: 21
view all 13 authors...
Bladder cancer (BC) is the ninth most common cancer worldwide, but molecular changes are still under study. During tumor progression, Epithelial cadherin (E-cadherin) expression is altered and β-catenin may be translocated to the nucleus, where it acts as co-transcription factor of tumor invasion associated genes. This investigation further characterizes E-cadherin and β-catenin associated changes in BC, by combining bioinformatics, an experimental murine cell model (MB49/MB39-I) and human BC sa...
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#1Mónica H. Vazquez-Levin (Instituto de Biología y Medicina Experimental)H-Index: 21
#2Gustavo Luis Verón (Instituto de Biología y Medicina Experimental)H-Index: 3
BACKGROUND: Myo-inositol (cis-1,2,3,5-trans-4,6-cyclohexanehexol; MI) is the most prominent of nine inositol stereoisomers. MI, its phosphate derivatives, and associated lipids are widely found in vegetables and animal tissues and are known to participate in numerous biological processes. OBJECTIVES: To perform a review analysis on MI presence, functions, and impact in male fertility. MATERIALS AND METHODS: A thorough search of listed publications in PubMed on MI and its derivatives was done. RE...
4 CitationsSource
#1María José Besso (Instituto de Biología y Medicina Experimental)H-Index: 4
#2Marina Rosso (Instituto de Biología y Medicina Experimental)H-Index: 6
Last. Mónica H. Vazquez-Levin (Instituto de Biología y Medicina Experimental)H-Index: 21
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Objective: Endometrial cancer (EC) is the second most common gynecological cancer worldwide. Myometrial invasion (MI) is a key event in EC dissemination. This study aimed to evaluate FXYD5/dysadherin (FXYD5/Dys) expression in EC tissue and uterine aspirate (UA) biopsies and to assess molecular/functional changes associated with its expression in cellular models. Methods: FXYD5/Dys messenger RNA (mRNA) levels were determined in EC tissue and UA biopsies. FXYD5/Dys expression was evaluated in EC R...
3 CitationsSource
#1Marina Rosso (Instituto de Biología y Medicina Experimental)H-Index: 6
#2Lara Lapyckyj (Instituto de Biología y Medicina Experimental)H-Index: 6
Last. Mónica H. Vazquez-Levin (Instituto de Biología y Medicina Experimental)H-Index: 21
view all 9 authors...
Background Breast cancer (BC) is the most common female cancer and the leading cause of cancer death in women worldwide. Alterations in epithelial cadherin (E-cadherin) expression and functions are associated to BC, but the underlying molecular mechanisms have not been fully elucidated. We have previously reported a novel human E-cadherin splice variant (E-cadherin variant) mRNA. Stable transfectants in MCF-7 human BC cells (MCF7Ecadvar) depicted fibroblast-like cell morphology, E-cadherin wild-...
5 CitationsSource
#1Lucía Saucedo (Instituto de Biología y Medicina Experimental)H-Index: 3
#2Regina Rumpel (MHH: Hannover Medical School)H-Index: 4
Last. Clara I. Marín-Briggiler (Instituto de Biología y Medicina Experimental)H-Index: 16
view all 9 authors...
: In previous studies, we described the presence of fibroblast growth factor 2 (FGF-2) and its receptors (FGFRs) in human testis and sperm, which are involved in spermatogenesis and in motility regulation. The aim of the present study was to analyze the role of FGF-2 in the maintenance of sperm physiology using FGF-2 knockout (KO) mice. Our results showed that in wild-type (WT) animals, FGF-2 is expressed in germ cells of the seminiferous epithelium, in epithelial cells of the epididymis, and in...
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#1Gustavo Luis Verón (Instituto de Biología y Medicina Experimental)H-Index: 3
#2Andrea TisseraH-Index: 10
Last. Mónica H. Vazquez-Levin (Instituto de Biología y Medicina Experimental)H-Index: 21
view all 7 authors...
Objective To assess the impact of aging on routine semen and computer-assisted sperm analysis (CASA) motility parameters according to the current World Health Organization guidelines; and to evaluate the effect of obesity and lifestyle (alcohol consumption, cigarette smoking) in older men's semen. Design Blind cross-sectional study. Setting Research laboratory and andrology and reproduction laboratory. Patient(s) A population of 11,706 men. Intervention(s) None. Main Outcome Measure(s) Semen ana...
29 CitationsSource
#1Lucía Saucedo (Instituto de Biología y Medicina Experimental)H-Index: 3
#2Cristian Marcelo Sobarzo (UBA: University of Buenos Aires)H-Index: 8
Last. Clara I. Marín-Briggiler (Instituto de Biología y Medicina Experimental)H-Index: 16
view all 9 authors...
Fil: Saucedo, Lucia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Biologia y Medicina Experimental. Fundacion de Instituto de Biologia y Medicina Experimental. Instituto de Biologia y Medicina Experimental; Argentina
4 CitationsSource