Kimiyoshi Ichida
Tokyo University of Pharmacy and Life Sciences
GeneInternal medicineEndocrinologyTransporterXanthine dehydrogenaseChemistryMolybdenum cofactor deficiencyHypouricemiaHyperuricemiaUric acidSLC22A12KidneyGoutSLC2A9Urate transportAbcg2GeneticsBiochemistryBioinformaticsMedicineBiologyGastroenterology
198Publications
34H-index
5,201Citations
Publications 198
Newest
#1Yukio Maruyama (Jikei University School of Medicine)H-Index: 18
#2Takanori Kumagai (Teikyo University)H-Index: 9
Last. Shunya Uchida (Teikyo Heisei University)H-Index: 1
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Whether uric acid (UA)-lowering therapy (ULT) is effective in reducing the progression of renal dysfunction in patients with chronic kidney disease (CKD) remains controversial. Since several advances have been made in therapies for hyperuricemia, including novel xanthine oxidoreductase (XOR) inhibitors, we conducted a systematic review to clarify the effectiveness of ULT in preserving renal function among CKD patients. In this systematic review, the MEDLINE database was searched up to June 2019....
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#1Yusuke Kawamura (National Defense Medical College)H-Index: 14
#2Akiyoshi Nakayama (National Defense Medical College)H-Index: 23
Last. Makoto Kawaguchi (National Defense Medical College)H-Index: 8
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Background: Renal hypouricemia (RHUC) is characterized by a low serum uric acid (SUA) level and high fractional excretion of uric acid (FEUA). Further studies on FEUA in hypouricemic individuals are needed for a more accurate diagnosis of RHUC. Methods: In 30,685 Japanese health-examination participants, we genotyped the two most common nonfunctional variants of URAT1 (NFV-URAT1), W258X (rs121907892) and R90H (rs121907896), in 1040 hypouricemic individuals (SUA ≤ 3.0 mg/dL) and 2240 individuals ...
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#1Akiyoshi Nakayama (National Defense Medical College)H-Index: 23
#2Yusuke Kawamura (National Defense Medical College)H-Index: 14
Last. Toshihiko Imakiire (National Defense Medical College)H-Index: 12
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OBJECTIVES Up to 0.3% of Japanese have hypouricemia. Most cases appear to result from a hereditary disease, renal hypouricemia (RHUC), which causes exercise-induced acute kidney injury and urolithiasis. However, to what extent RHUC accounts for hypouricemia is not known. We therefore investigated its frequency and evaluated its risks by genotyping a general Japanese population. METHODS A cohort of 4,993 Japanese was examined by genotyping the nonfunctional variants R90H (rs121907896) and W258X (...
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#1Kosuke Honda (Jikei University School of Medicine)H-Index: 1
#2Satoru Kuriyama (Jikei University School of Medicine)H-Index: 18
Last. Takashi Yokoo (Jikei University School of Medicine)H-Index: 28
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BACKGROUND Insulin-like growth factor-1 (IGF-1) acts on glucose and protein metabolism and human growth and also influences blood pressure and renal function. This study investigated whether the single-nucleotide polymorphism of IGF-1, rs35767, plays a role in metabolic syndrome indicators, including blood pressure, glucose metabolism, uric acid levels, and renal function. METHODS In this retrospective longitudinal cohort study, blood samples from 1506 Japanese individuals were collected and use...
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#1Yu Toyoda (National Defense Medical College)H-Index: 18
#2Yusuke Kawamura (National Defense Medical College)H-Index: 14
Last. Hirotaka Matsuo (National Defense Medical College)H-Index: 37
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OBJECTIVES Gout, caused by chronic elevation of serum uric acid levels, is the commonest form of inflammatory arthritis. The causative effect of common and rare variants of ATP-binding cassette transporter G2 (ABCG2/BCRP) on gout risk has been studied, but, little attention has been paid to the effect of common (rs121907892, p. W258X) and rare variants of urate transporter 1 (URAT1/SLC22A12) on gout, despite dysfunctional variants of URAT1 having been identified as pathophysiological causes of r...
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#1Akiyoshi Nakayama (National Defense Medical College)H-Index: 23
#2Hirotaka Matsuo (National Defense Medical College)H-Index: 37
Last. Nariyoshi Shinomiya (National Defense Medical College)H-Index: 38
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#1Yu Abe (Tohoku University)H-Index: 9
#2Yu Aihara (Tohoku University)H-Index: 1
Last. Shigeo Kure (Tohoku University)H-Index: 61
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Abstract Molybdenum cofactor deficiency (MoCD) is an autosomal recessive inborn error of metabolism that results from mutations in genes involved in molybdenum cofactor (Moco) biosynthesis. MoCD is characterized clinically by intractable seizures and severe, rapidly progressing neurodegeneration leading to death in early childhood in the majority of known cases. We report on a patient with an unusual late disease onset and mild phenotype, characterized by delayed development and a decline trigge...
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#1Kosuke HondaH-Index: 1
#2Satoru KuriyamaH-Index: 18
Last. Takashi YokooH-Index: 28
view all 6 authors...
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#1Kyoko Fujita (Tokyo University of Pharmacy and Life Sciences)H-Index: 16
#2Misaki Sekido (Tokyo University of Pharmacy and Life Sciences)
Last. Kimiyoshi Ichida (Tokyo University of Pharmacy and Life Sciences)H-Index: 34
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