Kacey G. Marra
University of Pittsburgh
Self-healing hydrogelsAdipogenesisBiomedical engineeringStem cell transplantation for articular cartilage repairSoft tissueSurgeryPathologyRegeneration (biology)Adipose tissueChemistryMaterials scienceMesenchymal stem cellAdult stem cellWound healingSciatic nerveStem cellTissue engineeringMedicineBiologyCell biology
Publications 212
#1Andy J. Lee (Columbia University)H-Index: 3
#2Christopher Mahoney (University of Pittsburgh)H-Index: 6
Last. Clark T. Hung (Columbia University)H-Index: 51
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Fibrosis of the knee is a common disorder resulting from an aberrant wound healing response and is characterized by extracellular matrix deposition, joint contraction, and scar tissue formation. The principal regulator of the fibrotic cascade is transforming growth factor beta-1 (TGF-β1), a factor that induces rapid proliferation and differentiation of resident fibroblasts. In this study, we demonstrate successful inhibition of TGF-β1-driven myofibroblastic differentiation in human fibroblast-li...
#1Debra A. Bourne (University of Pittsburgh)H-Index: 6
#2Jacqueline M. Bliley (University of Pittsburgh)H-Index: 12
Last. J. Peter RubinH-Index: 61
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OBJECTIVE: This study aimed to prospectively assess outcomes for surgical autologous fat transfer (AFT) applied for traumatic and postsurgical craniofacial deformities. The minimally invasive nature of AFT has potential for reduced risk and superior outcomes compared with current reconstructive options. BACKGROUND: Craniofacial deformities have functional and psychosocial sequelae and can profoundly affect quality of life. Traditional reconstructive options are invasive, invasive, complex, and o...
2 CitationsSource
#1Fuat Baris Bengur (University of Pittsburgh)H-Index: 2
#2Conrad Stoy (University of Pittsburgh)
Last. Kacey G. Marra (University of Pittsburgh)H-Index: 64
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Injury to the facial nerve can occur after different etiologies and range from simple transection of the branches to varying degrees of segmental loss. Management depends on the extent of the injury and options include primary repair for simple transections and using autografts, allografts or conduits for larger gaps. Tissue engineering plays an important role to create artificial materials that are able to mimic the nerve itself without extra morbidity in the patients. The use of neurotrophic f...
#1Juliana A. Passipieri (UVA: University of Virginia)H-Index: 8
#2Jack Dienes (UVA: University of Virginia)H-Index: 3
Last. George J. Christ (UVA: University of Virginia)H-Index: 63
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Severe peripheral nerve injuries have devastating consequences on the quality of life in affected patients, and they represent a significant unmet medical need. Destruction of nerve fibers results ...
4 CitationsSource
#1Riccardo Schweizer (University of Pittsburgh)H-Index: 14
#2Matthias Waldner (University of Pittsburgh)H-Index: 6
Last. J. Peter Rubin (University of Pittsburgh)H-Index: 61
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Background: Mesenchymal stromal cell (MSC)-based cytotherapies fuel the hope for reduction of chronic systemic immunosuppression in allotransplantation, and our group has previously shown this capability for both swine and human cells. MSCs harvested from distinct anatomical locations may have different behavior and lead to different outcomes in both preclinical research and human trials. To provide an effective reference for cell therapy studies, we compared human and porcine MSCs from omental ...
1 CitationsSource
#1Yi Zhou (CSU: Central South University)H-Index: 4
#2Xiaobo Xia (CSU: Central South University)H-Index: 13
Last. Yiqin Du (University of Pittsburgh)H-Index: 24
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The trabecular meshwork (TM) is an ocular tissue that maintains intraocular pressure (IOP) within a physiologic range. Glaucoma patients have reduced TM cellularity and, frequently, elevated IOP. To establish a stem cell-based approach to restoring TM function and normalizing IOP, human adipose-derived stem cells (ADSCs) were induced to differentiate to TM cells in vitro. These ADSC-TM cells displayed a TM cell-like genotypic profile, became phagocytic, and responded to dexamethasone stimulation...
5 CitationsSource
#1Benjamin K. Schilling (University of Pittsburgh)H-Index: 5
#2Kimberly K. Lamberti (University of Pittsburgh)H-Index: 1
Last. Kacey G. Marra (University of Pittsburgh)H-Index: 64
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Tissue decellularization for generating extracellular matrices has become a staple of regenerative medicine in the recent decades, extending from the research setting to clinical usage. Although me...
2 CitationsSource
#1Neil B. Fadia (University of Pittsburgh)H-Index: 1
#2Jacqueline M. Bliley (University of Pittsburgh)H-Index: 12
Last. Kacey G. Marra (University of Pittsburgh)H-Index: 64
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Severe injuries to peripheral nerves are challenging to repair. Standard-of-care treatment for nerve gaps >2 to 3 centimeters is autografting; however, autografting can result in neuroma formation, loss of sensory function at the donor site, and increased operative time. To address the need for a synthetic nerve conduit to treat large nerve gaps, we investigated a biodegradable poly(caprolactone) (PCL) conduit with embedded double-walled polymeric microspheres encapsulating glial cell line–deriv...
21 CitationsSource
#1Robert M. Stefani (Columbia University)H-Index: 6
#2Andy J. Lee (Columbia University)H-Index: 3
Last. Clark T. Hung (Columbia University)H-Index: 36
view all 11 authors...
Abstract Articular cartilage defects are a common source of joint pain and dysfunction. We hypothesized that sustained low-dose dexamethasone (DEX) delivery via an acellular osteochondral implant would have a dual pro-anabolic and anti-catabolic effect, both supporting the functional integrity of adjacent graft and host tissue while also attenuating inflammation caused by iatrogenic injury. An acellular agarose hydrogel carrier with embedded DEX-loaded poly(lactic-co-glycolic) acid (PLGA) micros...
6 CitationsSource