Hamid Mobedi
Morphology (linguistics)Analytical chemistryNuclear chemistryDegradation (geology)Controlled releasePhase inversionHigh-performance liquid chromatographyAqueous solutionChemistryPolymer chemistryMaterials scienceEthyl heptanoateIn situDrug deliveryPLGASolventImplantChemical engineeringChromatographyPolymerDiffusionMedicinePharmacology
61Publications
17H-index
737Citations
Publications 62
Newest
#1Arezou Soroushnia (TMU: Tarbiat Modares University)H-Index: 2
#2Fariba Ganji (TMU: Tarbiat Modares University)H-Index: 15
Last. Hamid MobediH-Index: 17
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Poorly soluble drugs are often a challenging problem in drug formulation. Midazolam is considered one of the best first-line drugs in managing status epilepticus in children who require emergency drug treatment. Owing to poor water solubility, however, oral bioavailability of midazolam is relatively low and insufficient. To improve its dissolution and absorption, nanosuspensions of midazolam hydrochloride were formulated with different stabilizers, such as Tween 80, Poloxamer 188, sodium carboxy...
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INTRODUCTION Typically, in situ forming implants utilize Poly (lactide-co-glycolide) (PLGA) as a carrier and N-methyl-2-pyrrolidone (NMP) as a solvent. However, it is essential to develop different carriers to release various drugs in a controlled and sustained manner with economic and safety considerations. OBJECTIVE The present study aims to evaluate the in-vitro release of Bupivacaine HCl from in situ forming systems as post-operative local anesthesia. METHODS We used Sucrose acetate isobutyr...
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#1Arezou Soroushnia (TMU: Tarbiat Modares University)H-Index: 2
#2Fariba Ganji (TMU: Tarbiat Modares University)H-Index: 15
Last. Hamid MobediH-Index: 17
view all 4 authors...
Midazolam is considered as one of the best first-line drugs in managing status epilepticus in children who require emergency drug treatment. Due to poor water solubility, oral bioavailability of midazolam is relatively low. To improve its dissolution and absorption, midazolam nano-suspensions were formulated with different stabilizers using the ultrasonic technique. A combination of Tween 80 and Poloxamer (TP) was considered as one stabilizer and 3-methyl chitosan (TMC) as another stabilizer. Th...
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#1Siyavash Mirzaei (Royan Institute)H-Index: 2
#2Hamid MobediH-Index: 17
Last. Hamid Omidian (NSU: Nova Southeastern University)H-Index: 6
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Objective: It is so difficult to formulate human growth hormone (hGH) in a solution with high stability and new drug delivery system (NDDs) due to physiochemical instability. The purpose of this study was to investigate the possibility of using Tris as a hGH stabilizer. Materials and Methods: In this experimental study, the role of tris(hydroxymethyl)aminomethane (Tris) was evaluated as a hGH stabilizing agent in phosphate buffer, as a practical aqueous solution and a media to release NDDs. High...
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Preparation of dexamethasone (Dex)-loaded chitosan beads were developed applying a surface-response methodology. The operational conditions were optimized with the aim of maximizing the loading capacity of Dex. The loading of the drug within the chitosan beads was carried out by ionotropic gelation technique with tetra sodium phosphate (TSP) as cross-linking agent with co-axial method that compared with simple mixing method. The co-axial method included loading of drug during dripping process us...
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#1Siyavash Mirzaei (Royan Institute)H-Index: 2
#2Hamid MobediH-Index: 17
Last. Sima Sadrai (UT: University of Tehran)
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A patient-friendly delivery system to release human growth hormone (hGH) is very desirable. In situ forming implant systems (ISIs) can provide a long acting and effective protein delivery. In these systems, solvents and additives play major roles in drug release. In this study, four groups of PLGA-based ISIs containing hGH were prepared in N-methyl-2-pyrrolidone (NMP) and poly(ethylene glycol) dimethyl ether (PEG-DME) as solvents with and without tris(hydroxymethyl) aminomethane (Tris) as stabil...
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ABSTRACTPaclitaxel-loaded poly(lactic acid-co-glycolic acid) (PLGA) microspheres containing different portions of human serum albumin microparticles (mHSA) were prepared via an in situ forming meth...
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#1Nooshafarin Amani (Tehran University of Medical Sciences)H-Index: 1
#2Farid Abedin Dorkoosh (Tehran University of Medical Sciences)H-Index: 35
Last. Hamid MobediH-Index: 17
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Antibody drug conjugates (ADCs), as potent pharmaceutical trojan horses for cancer treatment, provide superior efficacy and specific targeting along with low risk of adverse reactions compared to traditional chemotherapeutics. In fact, the development of these agents combines the selective targeting capability of monoclonal antibody (mAb) with high cytotoxicity of chemotherapeutics for controlling the neoplastic mass growth. Different ADCs (more than 60 ADCs) in preclinical and clinical trials w...
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#1Neda Radfar (IAU: Islamic Azad University)H-Index: 1
#2Hamid MobediH-Index: 17
Last. Arezou MashakH-Index: 7
view all 4 authors...
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#1Mina Hajihasani Biouki (IAU: Islamic Azad University)H-Index: 1
#2Hamid MobediH-Index: 17
Last. Morteza Daliri JoupariH-Index: 2
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Abstract The use of injectable scaffolds as a minimally invasive method is a good choice in tissue engineering applications. A critical parameter for the tissue engineering scaffolds is a suitable morphology with interconnected pores. We present the development of a simvastatin loaded scaffold that forms in situ and provides the porous structure with interconnected pores. The morphology results showed the resultant scaffold was porous with the interconnected pores. The scaffolds presented 91% po...
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