Gokhan Yahioglu
Imperial College London
Fluorescence anisotropyAnalytical chemistryCancerBiophysicsViscosityMicroviscosityPathologyAntibodyNanotechnologyLight-emitting diodeChemistryMaterials scienceConjugateIn vitroMUC1PorphyrinDrugPhotodynamic therapyCancer researchFluorescence-lifetime imaging microscopyMedicinePhotochemistryFluorescence
65Publications
24H-index
2,097Citations
Publications 62
Newest
#1Hayley Pye (UCL: University College London)H-Index: 9
#2Mohammed A. Butt (UCL: University College London)H-Index: 9
Last. Laurence Lovat (UCL: University College London)H-Index: 36
view all 18 authors...
In many cancers early intervention involves surgical resection of small localised tumour masses. Inadequate resection leads to recurrence whereas overzealous treatment can lead to organ damage. This work describes production of a HER2 targeting antibody Fab fragment dual conjugated to achieve both real time near-infrared fluorescent imaging and photodynamic therapy. The use of fluorescence emission from a NIR-dye could be used to guide resection of tumour bulk, for example during endoscopic diag...
12 CitationsSource
#1Sreetama Pal (Indian Institute of Chemical Technology)H-Index: 5
#2Hirak Chakraborty (Sambalpur University)H-Index: 19
Last. Amitabha Chattopadhyay (AcSIR: Academy of Scientific and Innovative Research)H-Index: 68
view all 6 authors...
The role of membrane cholesterol as a crucial regulator in the structure and function of membrane proteins and receptors is well documented. However, there is a lack of consensus on the mechanism for such regulation. We have previously shown that the function of an important neuronal receptor, the serotonin1A receptor, is modulated by cholesterol in hippocampal membranes. With an overall objective of addressing the role of membrane physical properties in receptor function, we measured the viscos...
16 CitationsSource
#1Luisa De Sordi (UCL Eastman Dental Institute)H-Index: 1
#1Luisa De Sordi (UCL Eastman Dental Institute)H-Index: 1
Last. Laurence Lovat (UCLH: University College Hospital)H-Index: 36
view all 13 authors...
BACKGROUND: Clostridium difficile is the leading cause of antibiotic-associated diarrhoea and pseudo membranous colitis in the developed world. The aim of this study was to explore whether Photodynamic Antimicrobial Chemotherapy (PACT) could be used as a novel approach to treating C. difficile infections. METHODS: PACT utilises the ability of light-activated photosensitisers (PS) to produce reactive oxygen species (ROS) such as free radical species and singlet oxygen, which are lethal to cells. ...
12 CitationsSource
#1M P Deonarain (The Hertz Corporation)H-Index: 3
#2Gokhan Yahioglu (Imperial College London)H-Index: 24
Last. Jared S. Marklew (The Hertz Corporation)H-Index: 3
view all 4 authors...
Introduction: Antibody drug conjugates now make up a significant fraction of biopharma’s oncology pipeline due to great advances in the understanding of the three key components and how they should be optimised together. With this clinical success comes innovation to produce new enabling technologies that can deliver more effective antibody-drug conjugates (ADCs) with a larger therapeutic index.Areas covered: There are many reviews that discuss the various strategies for ADCs design but the last...
43 CitationsSource
#1Yilei Wu (Imperial College London)H-Index: 27
#2Martin Štefl (Charles University in Prague)H-Index: 10
Last. Marina K. Kuimova (Imperial College London)H-Index: 38
view all 10 authors...
Understanding of cellular regulatory pathways that involve lipid membranes requires the detailed knowledge of their physical state and structure. However, mapping the viscosity and diffusion in the membranes of complex composition is currently a non-trivial technical challenge. We report fluorescence lifetime spectroscopy and imaging (FLIM) of a meso-substituted BODIPY molecular rotor localised in the leaflet of model membranes of various lipid compositions. We prepare large and giant unilamella...
94 CitationsSource
#1Mohammed A. Butt (UCL: University College London)H-Index: 9
#2Eleanor S. Bloom (UCL: University College London)
Last. Laurence Lovat (UCL: University College London)H-Index: 36
view all 10 authors...
Introduction Photodynamic therapy (PDT) has been used to both treat gastrointestinal (GI) cancers and for palliation. PDT has been limited by poor penetration of the laser light used to activate it. In recent years, PDT has been replaced by other minimally invasive modalities such as radiofrequency- and cryo-ablation due to fewer side effects. However, these are limited to superficial cancers. Activation of 2nd generation photosensitisers (PS) such as Talaporfin by light in the near infrared ena...
Source
#1Mohammed A. ButtH-Index: 9
#2Luisa De Sordi (UCL: University College London)H-Index: 1
Last. Laurence LovatH-Index: 36
view all 10 authors...
Introduction Clostridium difficile (CD) is the leading cause of hospital and community-acquired antibiotic-associated diarrhoea in the developed world. Since 2003, a new lineage of strains with more severe virulence has emerged, leading to an increased number of outbreaks of disease in North America and Europe and raising the impellent need for an effective therapy. Photodynamic Antimicrobial Chemotherapy (PACT) utilises the ability of light-activated photosensitisers (PS) to produce free radica...
2 CitationsSource
#1Mohammed A. ButtH-Index: 9
#2Luisa De Sordi (UCL: University College London)H-Index: 1
Last. Laurence LovatH-Index: 36
view all 10 authors...
Introduction Approximately 20% of patients with Clostridium difficile (CD) infection relapse after initially effective treatment. These typically occur 3–10 days after cessation of standard antibiotic therapy with vancomycin or metronidazole. Some patients relapse 2 or even 3 times, each requiring additional courses of antibiotics. The general consensus is that relapse occurs either because CD had not been completely eradicated by the antibiotics, or because spores are resistant to killing. Seve...
1 CitationsSource
#1Mohammed A. ButtH-Index: 9
#1Mohammed A. ButtH-Index: 2
Last. Laurence LovatH-Index: 36
view all 10 authors...
Aim: The aim of the present study was to evaluate whether chronomodulated administration of capecitabine would reduce toxicity of the drug in patients with metastatic colorectal cancer. Patients & Methods: 27 patients with advanced colorectal cancer were randomized to receive capecitabine (2500mg/KOF daily) either in standard administration with 50% of the dose in themorning and 50% in the evening separated by 12 hours or as chronomodulated dose-regime with 25% morning-dose and 75% late evening-...
Source
#1Hayley PyeH-Index: 9
#2Ioanna StamatiH-Index: 5
Last. Mahendra DeonarainH-Index: 19
view all 5 authors...
Photodynamic therapy (PDT) is a clinically-approved but rather under-exploited treatment modality for cancer and pre-cancerous superficial lesions. It utilises a cold laser or LED to activate a photochemical reaction between a light activated drug (photosensitiser-drug) and oxygen to generate cytotoxic oxygen species. These free radical species damage cellular components leading to cell death. Despite its benefits, the complexity, limited potency and side effects of PDT have led to poor general ...
20 CitationsSource