Francesco Giorgino
University of Bari
Insulin receptorPhosphorylationInternal medicineEndocrinologyReceptorAdipose tissueChemistryType 2 diabetesInsulin resistanceInsulinGlycemicPopulationType 2 Diabetes MellitusObesityDiabetes mellitusMedicineProtein kinase BBiologyCell biologyPharmacology
368Publications
64H-index
9,299Citations
Publications 369
Newest
#1Sergio Di Molfetta (University of Bari)H-Index: 5
#2Emanuele Bosi (UniSR: Vita-Salute San Raffaele University)H-Index: 63
Last. Francesco Giorgino (University of Bari)H-Index: 64
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Abstract null null Aims null To investigate the relationship between single therapeutic interventions and indicators of glycemic control in the PRISMA trial, a large study comparing the effects of intensive structured SMBG (ISM) vs. active control (AC) in non-insulin-treated T2D. null null null Methods null Information was collected at four time points, corresponding to months 3, 6, 9, and 12 and visits 2, 3, 4, and 5, respectively. Data on therapeutic interventions, HbA1c levels and the number ...
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#1Juris J. MeierH-Index: 74
#2Baptist Gallwitz (University of Tübingen)H-Index: 26
Last. Francesco Giorgino (University of Bari)H-Index: 64
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#1Irene Caruso (University of Bari)H-Index: 5
#2Sergio Di Molfetta (University of Bari)H-Index: 5
Last. Luigi Laviola (University of Bari)H-Index: 38
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AIMS: To assess changes in glucose metrics and their association with psychological distress and lifestyle changes in patients with type 1 diabetes (T1D) using flash glucose monitoring (FGM) during lockdown following severe acute respiratory syndrome coronavirus 2 outbreak. MATERIALS AND METHODS: Single-centre, observational, retrospective study enrolling T1D patients who attended a remote visit on April 2020 at the Endocrinology division of the University Hospital Policlinico Consorziale, Bari,...
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#1Irene Caruso (University of Bari)H-Index: 5
#2Angelo Cignarelli (University of Bari)H-Index: 22
Last. Francesco Giorgino (University of Bari)H-Index: 64
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#1Bernhard LudvikH-Index: 53
#2Francesco Giorgino (University of Bari)H-Index: 64
Last. Ángel RodríguezH-Index: 2
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Summary null null Background null Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide and GLP-1 receptor agonist under development for the treatment of type 2 diabetes. We aimed to assess the efficacy and safety of tirzepatide versus titrated insulin degludec in people with type 2 diabetes inadequately controlled by metformin with or without SGLT2 inhibitors. null null null Methods null In this open-label, parallel-group, multicentre (122 sites), multinational (13 countries)...
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#1Marta Baviera (Mario Negri Institute for Pharmacological Research)H-Index: 17
#2Stefano GenoveseH-Index: 34
Last. Francesco Giorgino (University of Bari)H-Index: 64
view all 12 authors...
AIM GLP-1 receptor agonists (GLP-1 RA) and SGLT-2 inhibitors (SGLT-2i) are recommended in type 2 diabetes subjects with established cardiovascular (CV) disease or at high CV risk. The efficacy and safety of GLP-1 RA and SGLT-2i compared with other anti-hyperglycemic agents (AHAs) was examined in large and unselected populations of Lombardy and Apulia regions in Italy. MATERIALS AND METHODS An observational cohort study of first-time users of GLP-1 RA, SGLT-2i or other AHAs was conducted from 201...
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#1Angelo Cignarelli (University of Bari)H-Index: 22
#2Alessandro Ciavarella (University of Bari)H-Index: 6
Last. Onofrio Resta (University of Bari)H-Index: 42
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INTRODUCTION Obstructive sleep apnoea (OSA) is an underdiagnosed condition frequently associated with glycaemic control impairment in patients with type 2 diabetes. AIM To assess the relationship between glycometabolic parameters and OSA in obese non-diabetic subjects. METHODS Ninety consecutive subjects (mean age 44.9 ± 12 years, mean BMI 42.1 ± 9 kg/m2) underwent polysomnography and a 2-h oral glucose tolerance test (OGTT). RESULTS OSA was identified in 75% of subjects, with a higher prevalenc...
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Leptin is a principal adipose-derived hormone mostly implicated in the regulation of energy balance through the activation of anorexigenic neuronal pathways. Comprehensive studies have established that the maintenance of certain concentrations of circulating leptin is essential to avoid an imbalance in nutrient intake. Indeed, genetic modifications of the leptin/leptin receptor axis and the obesogenic environment may induce changes in leptin levels or action in a manner that accelerates metaboli...
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#2Kristina S. Boye (Eli Lilly and Company)H-Index: 28
Last. Francesco Giorgino (University of Bari)H-Index: 64
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The TROPHIES observational study enrolled patients with type 2 diabetes mellitus (T2DM) initiating their first injectable treatment with the glucagon-like peptide 1 receptor agonists (GLP-1 RAs) dulaglutide or liraglutide. This manuscript focuses on the study design, baseline characteristics of the enrolled population, and factors associated with GLP-1 RA choice. TROPHIES is a prospective, observational, 24-month study conducted in France, Germany, and Italy. Inclusion criteria include adult pat...
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Erectile dysfunction (ED) is a long-term complication of type 2 diabetes (T2D) widely known to affect the quality of life. Several aspects of altered metabolism in individuals with T2D may help to compromise the penile vasculature structure and functions, thus exacerbating the imbalance between smooth muscle contractility and relaxation. Among these, advanced glycation end-products and reactive oxygen species derived from a hyperglycaemic state are known to accelerate endothelial dysfunction by ...
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