Meike Heurich
Cardiff University
Complement systemInternal medicineFactor HOncologyMolecular biologyComplement factor IComplement factor BChemistryAlternative complement pathwayThrombomodulinImmunologyLectin pathwayOchratoxin ALongitudinal studyCoagulationHemostasisPsychosisComplement (complexity)PopulationDense Deposit DiseaseComplement activityGeneticsBiochemistryMedicineCohortSchizophreniaBiologyCD46
Publications 21
#1Oliver D. Howes (South London and Maudsley NHS Foundation Trust)H-Index: 82
#2Connor Cummings (South London and Maudsley NHS Foundation Trust)
Last. Meike Heurich (Cardiff University)H-Index: 11
view all 3 authors...
#1G. McCluskey (Cardiff University)
#2G. E. Davies (Cardiff University)
Last. Meike Heurich (Cardiff University)H-Index: 11
view all 9 authors...
BackgroundComplement FH (FH) is a key regulator of complement activity whereas thrombin (FIIa) is central to hemostasis with both pro- and anticoagulant functions. Both have separately been shown to have auxiliary activities across the two systems. The purpose of this study was to determine the effect of FH on pro- and anti-coagulant functions and investigate the interaction between FH and thrombin. null MethodsTail bleeding time and hemolysis were measured in FH-deficient mice (CFH-/-). Activat...
#1Meike Heurich (Cardiff University)H-Index: 11
#2Melanie Föcking (RCSI: Royal College of Surgeons in Ireland)H-Index: 19
Last. David Cotter (RCSI: Royal College of Surgeons in Ireland)H-Index: 50
view all 5 authors...
Early identification and treatment significantly improve clinical outcomes of psychotic disorders. Recent studies identified protein components of the complement and coagulation systems as key pathways implicated in psychosis. These specific protein alterations are integral to the inflammatory response and can begin years before the onset of clinical symptoms of psychotic disorder. Critically, they have recently been shown to predict the transition from clinical high risk to first-episode psycho...
#1Alexander T. BakerH-Index: 6
#2Ryan Boyd (ASU: Arizona State University)H-Index: 1
Last. Chun Kit Chan (UIUC: University of Illinois at Urbana–Champaign)H-Index: 3
view all 20 authors...
Adenovirus derived vectors, based on chimpanzee adenovirus Y25 (ChAdOx1) and human adenovirus type 26 are proving critical in combating the 2019 SARS-CoV-2 pandemic. Following emergency use authorization, scale up in vaccine administration has inevitably revealed vaccine related adverse effects; too rare to observe even in large Phase-III clinical trials. These include vaccine-induced thrombotic thrombocytopenia (VITT), an ultra-rare adverse event in which patients develop life-threatening blood...
#1Ben M. FludeH-Index: 1
#2Giulio Nannetti (Cardiff University)H-Index: 10
Last. Marcella BassettoH-Index: 13
view all 9 authors...
MASP-2, mannose-binding protein-associated serine protease 2, is a key enzyme in the lectin pathway of complement activation. Hyperactivation of this protein by human coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2 has been found to contribute to aberrant complement activation in patients, leading to aggravated lung injury with potentially fatal consequences. This hyperactivation is triggered in the lungs through a conserved, direct interaction between MASP-2 and coronavirus nucleocapsid (N) pro...
#1Melanie Föcking (RCSI: Royal College of Surgeons in Ireland)H-Index: 19
#2Sophie Sabherwal (RCSI: Royal College of Surgeons in Ireland)H-Index: 5
Last. David Cotter (RCSI: Royal College of Surgeons in Ireland)H-Index: 50
view all 15 authors...
The complement cascade is a major component of the immune defence against infection, and there is increasing evidence for a role of dysregulated complement in major psychiatric disorders. We undertook a directed proteomic analysis of the complement signalling pathway (n = 29 proteins) using data-independent acquisition. Participants were recruited from the UK avon longitudinal study of parents and children (ALSPAC) cohort who participated in psychiatric assessment interviews at ages 12 and 18. P...
Immunoglobulin IgM is important for controlling viral and bacterial infections, and low immunoglobulin levels have been found in sepsis. There is a clear need to stratify sepsis patients according to the presence of an invading organism, compared to no organism identified, and SIRS patients, where organ dysfunction is a result of a non-infective process. The aim of this pilot study in a small cohort of patients with sepsis was to evaluate the association between IgM plasma levels and survival in...
#1David Mongan (RCSI: Royal College of Surgeons in Ireland)H-Index: 6
#2Melanie Föcking (Beaumont Hospital)H-Index: 1
Last. Philip McGuire ('KCL': King's College London)H-Index: 145
view all 30 authors...
Importance Biomarkers that are predictive of outcomes in individuals at risk of psychosis would facilitate individualized prognosis and stratification strategies. Objective To investigate whether proteomic biomarkers may aid prediction of transition to psychotic disorder in the clinical high-risk (CHR) state and adolescent psychotic experiences (PEs) in the general population. Design, Setting, and Participants This diagnostic study comprised 2 case-control studies nested within the European Netw...
#1Francisco Madrid-Gambin (RCSI: Royal College of Surgeons in Ireland)H-Index: 9
#2Melanie Föcking (RCSI: Royal College of Surgeons in Ireland)H-Index: 19
Last. Lorraine Brennan (UCD: University College Dublin)H-Index: 58
view all 19 authors...
Abstract Background The identification of early biomarkers of psychotic experiences (PEs) is of interest because early diagnosis and treatment of those at risk of future disorder is associated with improved outcomes. The current study investigated early lipidomic and coagulation pathway protein signatures of later PEs in subjects from the Avon Longitudinal Study of Parents and Children cohort. Methods Plasma of 115 children (12 years of age) who were first identified as experiencing PEs at 18 ye...
#1David A. Slatter (Cardiff University)H-Index: 17
#2Charles L. Percy (Cardiff University)H-Index: 4
Last. Valerie B. O'DonnellH-Index: 60
view all 21 authors...
Hemostatic defects are treated using coagulation factors; however, clot formation also requires a procoagulant phospholipid (PL) surface. Here, we show that innate immune cell–derived enzymatically oxidized phospholipids (eoxPL) termed hydroxyeicosatetraenoic acid–phospholipids (HETE-PLs) restore hemostasis in human and murine conditions of pathological bleeding. HETE-PLs abolished blood loss in murine hemophilia A and enhanced coagulation in factor VIII- (FVIII-), FIX-, and FX-deficient human p...
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