Azzam Saleh-Mghir
Université Paris-Saclay
Drug resistanceInternal medicineSurgeryMaterials scienceIn vivoEndocarditisMethicillin-resistant Staphylococcus aureusKlebsiella pneumoniaeStaphylococcal infectionsPanton–Valentine leukocidinDaptomycinVancomycinColistinStaphylococcus aureusOsteomyelitisAntibacterial agentRabbit modelAntimicrobialAntibioticsPolymerMedicineBiologyMicrobiologyPharmacology
Publications 28
#1Benjamin Davido (Université Paris-Saclay)H-Index: 13
#2Pierre de Truchis (Université Paris-Saclay)H-Index: 13
Last. Sylvain GautierH-Index: 3
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#1Houssam Bouloussa (UVSQ: Versailles Saint-Quentin-en-Yvelines University)H-Index: 8
#2Azzam Saleh-Mghir (French Institute of Health and Medical Research)H-Index: 12
Last. Vincent Humblot (University of Paris)H-Index: 28
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3 CitationsSource
#1Benjamin Davido (Université Paris-Saclay)H-Index: 13
#2Ghilas Boussaid (Université Paris-Saclay)H-Index: 1
Last. Covid Rpc Team (Université Paris-Saclay)H-Index: 2
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Abstract Introduction Interest of anti-infective agents in COVD-19 showed discrepant results. However, there is no evaluation about the impact in changes of practices on the prognosis over time. Methods Single center, retrospective study, conducted from March 5th to April 25th 2020, in adults hospitalized in a medicine ward for a COVID-19. Patient characteristics were compared between 2 periods (before/after March 19th) considering French guidelines issued by learned societies. Aim of the study ...
11 CitationsSource
#1Pierre Tattevin (French Institute of Health and Medical Research)H-Index: 39
#2Aurélien DinhH-Index: 16
Last. Anne-Claude Crémieux (University of Paris)H-Index: 16
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ABSTRACT Guidelines for the management of carbapenemase-producing Enterobacterales (CPE) infections recommend a combination of two active agents, including meropenem if MIC ≤ 8 mg/L. The therapeutic equivalence of meropenem generics has been challenged. We compared the bactericidal activity of meropenem princeps (AstraZeneca), and four different generic products (Actavis, Kabi, Mylan, Panpharma), in vitro and in vivo, in association with colistin. In vitro time-kill studies were performed at 4 x...
1 CitationsSource
#2Aurélien DinhH-Index: 16
Last. Frédéric Laurent (École normale supérieure de Lyon)H-Index: 41
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In a new experimental model of carbapenemase-producing Klebsiella pneumoniae osteomyelitis we evaluated the efficacy of colistin alone and in various combinations and examined the emergence of colistin-resistant strains and cross-resistance to host defence peptides (HDPs).
9 CitationsSource
#1Sophie Reissier (UVSQ: Versailles Saint-Quentin-en-Yvelines University)H-Index: 3
#2Azzam Saleh-Mghir (French Institute of Health and Medical Research)H-Index: 12
Last. Anne-Claude Crémieux (French Institute of Health and Medical Research)H-Index: 16
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Objectives: Daptomycin has become a first-line therapeutic option for vancomycin-resistant Enterococcus faecium infective endocarditis (IE). Although high doses (≥8 mg/kg) are often recommended, optimal doses, particularly for strains with MICs close to the susceptibility breakpoint (4 mg/L), are still debated. Methods: Daptomycin efficacy at doses equivalent to 8 mg/kg daptomycin (DAP8) and 12 mg/kg daptomycin (DAP12) in humans was evaluated in a rabbit model of aortic valve IE induced by 108 c...
3 CitationsSource
#1Hamza Chouirfa (ISPG: Institut Galilée)H-Index: 4
#2Margaret D. M. Evans (CSIRO: Commonwealth Scientific and Industrial Research Organisation)H-Index: 20
Last. Véronique Migonney (ISPG: Institut Galilée)H-Index: 25
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The aim of this Research Article is to present three different techniques of poly(sodium styrene sulfonate) (polyNaSS) covalent grafting onto titanium (Ti) surfaces and study the influence of their architecture on biological response. Two of them are “grafting from” techniques requiring an activation step either by thermal or UV irradiation. The third method is a “grafting to” technique involving an anchorage molecule onto which polyNaSS synthesized by reversible addition–fragmentation chain tra...
17 CitationsSource
In France, Carbapenem-Resistant Enterobacteriaceae (CRE) and Vancomycin-Resistant Enterococci (VRE) are considered as Extensively Drug-Resistant (XDR) bacteria. Their management requires reinforcement of hospital’s hygiene policies, and currently there is few consistent data concerning the spontaneous decolonization in XDR colonized patients. Our aim is to study the natural history of decolonization of XDR carriers over time in a hospital setting in a low prevalence country. Retrospective multic...
15 CitationsSource
#1L. GatinH-Index: 4
#2Azzam Saleh-MghirH-Index: 12
Last. Anne-Claude CrémieuxH-Index: 16
view all 7 authors...