Lidia Ciccone
University of Pisa
Matrix metalloproteinaseLigand (biochemistry)TransthyretinDocking (molecular)BiophysicsSolubilitySmall moleculeEnzymeChemistryCrystallizationCombinatorial chemistryNeuroprotectionFibrilProteasePolyethylene glycolTetramerAmyloidosisSolubilizationBiochemistryTransport proteinStereochemistryCrystallographyLigandBiology
35Publications
9H-index
206Citations
Publications 35
Newest
#1Lidia Ciccone (UniPi: University of Pisa)H-Index: 9
#2Susanna Nencetti (UniPi: University of Pisa)H-Index: 18
Last. Elisabetta Orlandini (UniPi: University of Pisa)H-Index: 20
view all 4 authors...
Neuroglobin (Ngb) is a 17 kDa monomeric hexa-coordinated heme protein belonging to the globin family. Ngb is mainly expressed in neurons of the central and peripheral nervous system, although moderate levels of Ngb have been detected in non-nervous tissues. In the past decade, Ngb has been studied for its neuroprotective role in a large number of neurological disorders such as Alzheimer's disease, Huntington's disease, brain ischemia and hypoxia. This review discusses and summarizes the natural ...
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#1Alessio Nocentini (UniFI: University of Florence)H-Index: 26
#2Doretta Cuffaro (UniPi: University of Pisa)H-Index: 5
Last. Claudiu T. Supuran (UniFI: University of Florence)H-Index: 152
view all 8 authors...
The synthesis and carbonic anhydrase (CA; EC 4.2.1.1) activating effects of a series of oxime ether-based amino alcohols towards four human (h) CA isoforms expressed in human brain, hCA I, II, IV a...
2 CitationsSource
#1Nicolo Tonali (Université Paris-Saclay)H-Index: 5
#2Susanna Nencetti (UniPi: University of Pisa)H-Index: 18
Last. Lidia Ciccone (UniPi: University of Pisa)H-Index: 9
view all 4 authors...
1 CitationsSource
#1Vibhu Jha (UniPi: University of Pisa)H-Index: 3
#2Salvatore Galati (UniPi: University of Pisa)H-Index: 2
Last. Tiziano Tuccinardi (UniPi: University of Pisa)H-Index: 35
view all 9 authors...
: ATP citrate lyase (ACLY) is an important enzyme that catalyzes the conversion of citrate to acetyl-CoA in normal cells, facilitating the de novo fatty acid synthesis. Lipids and fatty acids were found to be accumulated in different types of tumors, such as brain, breast, rectal and ovarian cancer, representing a great source of energy for cancer cell growth and metabolism. Since ACLY-mediated conversion of citrate to acetyl-CoA constitutes the basis for fatty acid synthesis, ACLY seems to be q...
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#1Lidia CicconeH-Index: 9
#2Nicolo TonaliH-Index: 5
Last. Elisabetta OrlandiniH-Index: 3
view all 5 authors...
Transthyretin (TTR) is a plasma homotetrameric protein that transports thyroxine and retinol. TTR itself, under pathological conditions, dissociates into partially unfolded monomers that aggregate and form fibrils. Metal ions such as Zn2+, Cu2+, Fe2+, Mn2+ and Ca2+ play a controversial role in the TTR amyloidogenic pathway. TTR is also present in cerebrospinal fluid (CSF), where it behaves as one of the major Aβ-binding-proteins. The interaction between TTR and Aβ is stronger in the presence of ...
1 CitationsSource
#1Lidia Ciccone (UniPi: University of Pisa)H-Index: 9
#2Jennifer Vandooren (Rega Institute for Medical Research)H-Index: 18
Last. Elisabetta Orlandini (UniPi: University of Pisa)H-Index: 20
view all 4 authors...
Several studies have reported neuroprotective effects by natural products. A wide range of natural compounds have been investigated, and some of these may play a beneficial role in Alzheimer's disease (AD) progression. Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, have been implicated in AD. In particular, MMP-2 and MMP-9 are able to trigger several neuroinflammatory and neurodegenerative pathways. In this review, we summarize and discuss existing literature on nat...
2 CitationsSource
#1Salvatore Santamaria (Imperial College London)H-Index: 14
#2Doretta Cuffaro (UniPi: University of Pisa)H-Index: 5
Last. Josefin Ahnström (Imperial College London)H-Index: 16
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ADAMTS-5 is a major protease involved in the turnover of proteoglycans such as aggrecan and versican. Dysregulated aggrecanase activity of ADAMTS-5 has been directly linked to the etiology of osteoarthritis (OA). For this reason, ADAMTS-5 is a pharmaceutical target for the treatment of OA. ADAMTS-5 shares high structural and functional similarities with ADAMTS-4, which makes the design of selective inhibitors particularly challenging. Here we exploited the ADAMTS-5 binding capacity of β-N-acetyl...
4 CitationsSource
#1Susanna Nencetti (UniPi: University of Pisa)H-Index: 18
#2Doretta Cuffaro (UniPi: University of Pisa)H-Index: 5
Last. Elisabetta Orlandini (UniPi: University of Pisa)H-Index: 20
view all 14 authors...
Uveal melanoma (UM) represents an aggressive type of cancer and currently, there is no effective treatment for this metastatic disease. In the last years, histone deacetylase inhibitors (HDACIs) have been studied as a possible therapeutic treatment for UM, alone or in association with other chemotherapeutic agents. Here we synthesised a series of new HDACIs based on the SAHA scaffold bearing an (arylidene)aminoxy moiety. Their HDAC inhibitory activity was evaluated on isolated human HDAC1, 3, 6,...
1 CitationsSource
#1Lidia Ciccone (UniPi: University of Pisa)H-Index: 9
#2Susanna Nencetti (UniPi: University of Pisa)H-Index: 18
Last. Elisabetta Orlandini (UniPi: University of Pisa)H-Index: 20
view all 9 authors...
Abstract Transthyretin (TTR) is a s-sheet-rich homotetrameric protein that transports thyroxine (T4) and retinol both in plasma and in cerebrospinal fluid. TTR also interacts with amyloid-β, playing a protective role in Alzheimer’s disease. Dissociation of the native transthyretin (TTR) tetramer is widely accepted as the critical step in TTR amyloids fibrillogenesis, and is responsible for extracellular deposition of amyloid fibrils. Small molecules, able to bind in T4 binding sites and stabiliz...
1 CitationsSource
#1Salvatore Santamaria (Imperial College London)H-Index: 14
#2Doretta Cuffaro (UniPi: University of Pisa)H-Index: 5
Last. Josefin Ahnstroem (Imperial College London)
view all 10 authors...
ADAMTS-5 is a major protease involved in the turnover of proteoglycans such as aggrecan and versican. Its aggrecanase activity has been directly linked to the etiology of osteoarthritis (OA), identifying ADAMTS-5 as a pharmaceutical target for OA treatment. However, most existing ADAMTS-5 inhibitors target its active site and therefore suffer from poor selectivity. Here, using a novel approach, we have designed a new class of sugar-based arylsulfonamide inhibitors, which are selective for ADAMTS...
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