Patrick Dicker
Royal College of Surgeons in Ireland
Internal medicineObstetricsEndocrinologyCardiologyNeuroscienceFetusPediatricsProspective cohort studyGestational ageIntrauterine growth restrictionPregnancyGynecologyFetal growthGestationBirth weightMedicineCohortSchizophreniaBiologyPlatelet
221Publications
32H-index
3,131Citations
Publications 219
Newest
#1Russell L. Deter (BCM: Baylor College of Medicine)H-Index: 38
#2Wesley Lee (BCM: Baylor College of Medicine)H-Index: 32
Last. Karen Flood (RCSI: Royal College of Surgeons in Ireland)H-Index: 9
view all 7 authors...
AbstractBackground: Fetal growth restriction is being defined as either “early” or “late” depending on age of onset. A recent investigation using individualized assessment has identified five diffe...
3 CitationsSource
#1Adam Lafferty (RCSI: Royal College of Surgeons in Ireland)H-Index: 3
#2Alice C. O’Farrell (RCSI: Royal College of Surgeons in Ireland)H-Index: 4
Last. Elodie Modave (Katholieke Universiteit Leuven)H-Index: 4
view all 0 authors...
Purpose null Regorafenib (REG) is approved for the treatment of mCRC, but has modest survival benefit and associated toxicities. Robust predictive/early response biomarkers to aid patient stratification are outstanding. We have exploited biological pathway analyses in a patient derived xenograft (PDX) trial to study REG response mechanisms and elucidate putative biomarkers. null Experimental design null Molecularly subtyped PDXs were annotated for REG response. Subtyping was based on gene expres...
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#1Russell L. Deter (BCM: Baylor College of Medicine)H-Index: 38
#2Wesley Lee (BCM: Baylor College of Medicine)H-Index: 32
Last. Karen Flood (RCSI: Royal College of Surgeons in Ireland)H-Index: 9
view all 7 authors...
OBJECTIVE We have previously shown that 3rd trimester growth in small fetuses (EFW 10th percentile are also variable but in different ways. METHODS This investigation was carried out on 191 fetuses/neonates derived from the PORTO study with EFW 10th percentile. Composite size parameters were used to quantify growth pathology at individual third trimester time points (individual composite Prenatal Growth Assessment Score {-icPGAS}). The Fetal Growth Pathology Score 1 (-FGPS1), calculated cumulati...
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#1Jill Mulrain (University Hospital Waterford)
#2Jennifer Hennebry (University Hospital Waterford)
Last. Joseph O’Beirne (University Hospital Waterford)H-Index: 2
view all 6 authors...
BACKGROUND Screening for developmental hip dysplasia (DDH) continues to evolve with the use of ultrasound (US) in either selective or universal screening methods. The possibility of delayed evidence of DDH, and thus the need for radiographic follow-up at a later stage of development have been suggested by some authors. AIMS The aim of this review was to evaluate the number of patients in our hospital network with a normal screening US at 6 weeks with evidence of DDH at the time of radiographic r...
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#1Melanie Föcking (RCSI: Royal College of Surgeons in Ireland)H-Index: 18
#2Sophie Sabherwal (RCSI: Royal College of Surgeons in Ireland)H-Index: 4
Last. David Cotter (RCSI: Royal College of Surgeons in Ireland)H-Index: 48
view all 15 authors...
The complement cascade is a major component of the immune defence against infection, and there is increasing evidence for a role of dysregulated complement in major psychiatric disorders. We undertook a directed proteomic analysis of the complement signalling pathway (n = 29 proteins) using data-independent acquisition. Participants were recruited from the UK avon longitudinal study of parents and children (ALSPAC) cohort who participated in psychiatric assessment interviews at ages 12 and 18. P...
14 CitationsSource
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#1Kate Connor (RCSI: Royal College of Surgeons in Ireland)H-Index: 6
#2David Murray (RCSI: Royal College of Surgeons in Ireland)H-Index: 57
Last. Annette T. Byrne (RCSI: Royal College of Surgeons in Ireland)H-Index: 24
view all 16 authors...
Glioblastoma (GBM), a highly invasive and vascular malignancy is shown to rapidly develop resistance and evolve to a more invasive phenotype following bevacizumab (Bev) therapy. Rho Guanine Nucleotide Exchange Factor proteins (RhoGEFs) are mediators of key components in Bev resistance pathways, GBM and Bev-induced invasion. To identify GEFs with enhanced mRNA expression in the leading edge of GBM tumours, a cohort of GEFs was assessed using a clinical dataset. The GEF βPix/COOL-1 was identified,...
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#1Alice C. O’Farrell (RCSI: Royal College of Surgeons in Ireland)H-Index: 4
#2Monika A. Jarzabek (RCSI: Royal College of Surgeons in Ireland)H-Index: 9
Last. Jochen H. M. Prehn (RCSI: Royal College of Surgeons in Ireland)H-Index: 80
view all 23 authors...
Resistance to chemotherapy often results from dysfunctional apoptosis, however multiple proteins with overlapping functions regulate this pathway. We sought to determine whether an extensively validated, deterministic apoptosis systems model, 'DR_MOMP', could be used as a stratification tool for the apoptosis sensitiser and BCL-2 antagonist, ABT-199 in patient-derived xenograft (PDX) models of colorectal cancer (CRC). Through quantitative profiling of BCL-2 family proteins, we identified two PDX...
2 CitationsSource
#1Niamh C. Murphy (RCSI: Royal College of Surgeons in Ireland)H-Index: 5
#2Naomi Burke (RCSI: Royal College of Surgeons in Ireland)H-Index: 5
Last. Fionnuala Breathnach (RCSI: Royal College of Surgeons in Ireland)H-Index: 13
view all 11 authors...
Abstract Objective The ability to predict the need for emergency Cesarean delivery holds the potential to facilitate birth choices. The objective of the RECIPE study (Reducing Emergency Cesarean delivery and Improving the Primiparous Experience) was to externally validate a Cesarean delivery risk prediction model. This model, developed by the Genesis study, identified five key predictive factors for emergency Cesarean delivery: maternal age, maternal height, BMI, fetal head circumference (HC) an...
1 CitationsSource
#1Russell L. Deter (BCM: Baylor College of Medicine)H-Index: 38
#2Wesley Lee (BCM: Baylor College of Medicine)H-Index: 32
Last. Karen Flood (RCSI: Royal College of Surgeons in Ireland)H-Index: 9
view all 7 authors...
To characterize abnormal growth processes and their associated cardiovascular abnormalities in SGA fetuses using Individualized Growth Assessment (IGA). This longitudinal investigation utilized a S...
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