Chantal P. Bleeker-Rovers
Radboud University Nijmegen
Internal medicineRadiologySurgeryPathologyRetrospective cohort studyPediatricsProspective cohort studyImmunologyPositron emission tomographyEndocarditisCoxiella burnetiiDiseaseFever of unknown originBacteremiaQ feverNuclear medicineMedicineComplicationBiologyGastroenterology
182Publications
36H-index
4,027Citations
Publications 164
Newest
#1Sheila B Buijs (UU: Utrecht University)H-Index: 1
#1S.B. Buijs (UU: Utrecht University)
Last. Chantal P. Bleeker-Rovers (Radboud University Nijmegen)H-Index: 36
view all 9 authors...
Abstract Objectives Chronic Q fever is a persistent infection with the intracellular bacterium Coxiella burnetii. Development of chronic Q fever is associated with single nuclear polymorphisms (SNPs) in genes encoding for pattern recognition receptors, for phagolysosomal pathway components and for matrix metalloproteinases (MMPs). In the current study we evaluated the association of SNPs in these innate immunity and MMP genes with clinical outcomes. Methods SNPs were selected from previous assoc...
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#1Sheila B Buijs (UU: Utrecht University)H-Index: 1
#2Sonja E. van Roeden (UU: Utrecht University)H-Index: 4
Last. Jan Jelrik Oosterheert (UU: Utrecht University)H-Index: 24
view all 7 authors...
Abstract Objectives We assessed the prognostic value of phase I IgG titers during treatment and follow-up of chronic Q fever. Methods We performed a retrospective cohort study to analyze the course of phase I IgG titers in chronic Q fever. We used a multivariable time-varying Cox regression to assess our primary (first disease-related event) and secondary (therapy failure) outcomes. In a second analysis, we evaluated serological characteristics after one year of therapy (fourfold decrease in pha...
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#1Catharina M. Mulders-Manders (Radboud University Nijmegen)H-Index: 7
#2Ilse J.E. Kouijzer (Radboud University Nijmegen)H-Index: 9
Last. Chantal P. Bleeker-Rovers (Radboud University Nijmegen)H-Index: 36
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BACKGROUND: [18F]FDG-PET/CT is one of the most important diagnostic techniques in the work-up of patients with FUO/IUO. Little is known how to optimize the diagnostic value of [18F]FDG-PET/CT in patients with FUO/IUO. METHODS: Retrospective study in all patients who underwent [18F]FDG-PET/CT during the work-up of FUO/IUO in a tertiary expert center between 2005 and 2014. Data were extracted from medical records. RESULTS: 104 patients were identified, of whom 68 had a final diagnosis (65.4%), mai...
1 CitationsSource
#1Ilse J.E. Kouijzer (Radboud University Nijmegen)H-Index: 9
#2Eline J van Leerdam (Radboud University Nijmegen)
Last. Jaap ten Oever (Radboud University Nijmegen)H-Index: 12
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In this retrospective cohort study, selected patients with disseminated Staphylococcus aureus bacteremia, but without endovascular infection on echocardiography and 18F-FDG-PET/CT, were free of relapse after iv-oral switch. Mortality was low and similar to patients who received prolonged intravenous treatment. Iv-oral switch was associated with a shorter length of hospital stay.
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#1Sheila B Buijs (UU: Utrecht University)H-Index: 1
#2Sanne K. Stuart (Bosch)
Last. Olivier H.J. Koning (Bosch)H-Index: 12
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We evaluated the long-term serological follow-up of patients with vascular risk factors for chronic Q fever that were previously Coxiella burnetii seropositive. C. burnetii phase I IgG titers were reevaluated in patients that gave informed consent or retrospectively collected in patients already deceased or lost to follow-up. Of 107 patients, 25 (23.4%) became seronegative, 77 (72.0%) retained a profile of past resolved Q fever infection, and five (4.7%) developed chronic Q fever. We urge clinic...
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#1Steven Schalekamp (Radboud University Nijmegen)H-Index: 7
#2Chantal P. Bleeker-Rovers (Radboud University Nijmegen)H-Index: 36
Last. Mathias ProkopH-Index: 70
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Background Clinicians need rapid and reliable diagnosis of coronavirus disease 2019 (COVID-19) for proper risk stratification, isolation strategies, and treatment decisions. Purpose To assess the real-life performance of radiologist emergency department chest CT interpretation for diagnosing COVID-19 during the acute phase of the pandemic, using the COVID-19 reporting and data system (CO-RADS). Materials and Methods This retrospective multicenter study included consecutive patients who presented...
5 CitationsSource
#1Michelle Gompelman (Radboud University Nijmegen)H-Index: 1
#2Heiman F. L. Wertheim (Radboud University Nijmegen)H-Index: 47
Last. Geert J. A. Wanten (Radboud University Nijmegen)H-Index: 29
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Abstract Background While in other groups S. aureus eradication has proven to be an effective infection prevention measure, no such studies have been performed in patients on HPN. This study investigates the efficacy of chronic nasal mupirocin use on S. aureus eradication and prevention of catheter related infections in HPN patients. Methods in this cohort study data was collected from adult HPN patients who were screened for S. aureus carriage. In case of carriage, the patient was instructed to...
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#1Ruud P. H. Raijmakers (Radboud University Nijmegen)H-Index: 6
#2Megan E. Roerink (Radboud University Nijmegen)H-Index: 6
Last. C.-J. Xu (MHH: Hannover Medical School)
view all 11 authors...
2 CitationsSource
#1Femke Wolters (Radboud University Nijmegen)H-Index: 5
#2Jordy P. M. Coolen (Radboud University Nijmegen)H-Index: 5
Last. Willem J. G. Melchers (Radboud University Nijmegen)H-Index: 75
view all 13 authors...
1 CitationsSource
#1Bram van den Borst (Radboud University Nijmegen)H-Index: 2
#2Jeannette B. Peters (Radboud University Nijmegen)H-Index: 13
Last. Michel M. van den Heuvel (Radboud University Nijmegen)H-Index: 25
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Background Long-term health sequelae of COVID-19 may be multiple but have thus far not been systematically studied. Methods All patients discharged after COVID-19 from the Radboud university medical centre, Nijmegen, The Netherlands, were consecutively invited to a multidisciplinary outpatient facility. Also, non-admitted patients with mild disease but with symptoms persisting >6 weeks could be referred by general practitioners. Patients underwent a standardized assessment including measurements...
24 CitationsSource