Ottmar Distl
University of Veterinary Medicine Vienna
GeneAnatomyGenotypeAnimal scienceSingle-nucleotide polymorphismMolecular biologyGermanHeritabilityBreedRadiation hybrid mappingInbreedingWarmbloodPopulationExonVeterinary medicineGeneticsMicrosatelliteCandidate geneMedicineBiology
398Publications
31H-index
4,081Citations
Publications 399
Newest
#1Reinhard MischkeH-Index: 17
#2Julia MetzgerH-Index: 13
Last. Ottmar DistlH-Index: 31
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Congenital fibrinogen disorders are very rare in dogs. Cases of afibrinogenemia have been reported in Bernese Mountain, Bichon Frise, Cocker Spaniel, Collie, Lhasa Apso, Viszla, and St. Bernard dogs. In the present study, we examined four miniature wire-haired Dachshunds with afibrinogenemia and ascertained their pedigree. Homozygosity mapping and a genome-wide association study identified a candidate genomic region at 50,188,932–64,187,680 bp on CFA15 harboring FGB (fibrinogen beta chain), FGA ...
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The bacterium Dichelobacter nodosus (D. nodosus) is the causative agent of ovine footrot. The aim of this field study was to determine the prevalence of D. nodosus in German sheep flocks. The sheep owners participated voluntarily in the study. More than 9000 sheep from 207 flocks were screened for footrot scores using a Footrot Scoring System from 0 to 5 and sampling each sheep using one interdigital swab for all four feet of the sheep. The detection and discrimination between benign and virulen...
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Increase of inbreeding and loss of genetic diversity have large impact on farm animal genetic resources. Therefore, the aims of the present study were to analyse measures of genetic diversity as well as recent and ancestral inbreeding using pedigree data of the German Brown population, and to identify causes for loss of genetic diversity. The reference population included 922,333 German Brown animals born from 1990 to 2014. Pedigree depth and completeness reached an average number of complete eq...
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#1Marina BraunH-Index: 3
#2Annika LehmbeckerH-Index: 9
Last. Ottmar DistlH-Index: 31
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BACKGROUND Bovine frontonasal dysplasias like arhinencephaly, synophthalmia, cyclopia and anophthalmia are sporadic congenital facial malformations. In this study, computed tomography, necropsy, histopathological examinations and whole genome sequencing on an Illumina NextSeq500 were performed to characterize a stillborn Limousin calf with frontonasal dysplasia. In order to identify private genetic and structural variants, we screened whole genome sequencing data of the affected calf and unaffec...
2 CitationsSource
#1Julia MetzgerH-Index: 13
#2Oliver KreftH-Index: 1
Last. Ottmar DistlH-Index: 31
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BACKGROUND: Warmblood Fragile Foal Syndrome (WFFS) is a lethal condition detected in Warmblood horses. Its origin and association with performance traits and fertility among horse populations is unknown. OBJECTIVES: To validate the previously identified WFFS type 1 (WFFST1)-associated missense variant PLOD1:c.2032G>A and to investigate its distribution among various horses with particular focus on Hanoverian breed, as well as its pathomorphologic picture. The study aimed at identifying the origi...
2 CitationsSource
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#1Kirsten Hahn (LMU: Ludwig Maximilian University of Munich)H-Index: 1
#2Theresa M. Conze (LMU: Ludwig Maximilian University of Munich)
Last. Tanja S. Witte (LMU: Ludwig Maximilian University of Munich)H-Index: 1
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Abstract A 5-month old draft horse filly was presented with incontinence and severe perivulvar dermatitis, which developed during the previous 2 months. Left-sided ectopic ureter entering in the caudal vaginal lumen, signs of cervix hypoplasia and urine accumulation in the uterus were found during initial vaginal endoscopy. Therefore, a left ureter-nephrectomy was conducted under general anesthesia. Additionally, a cytogenetic examination was performed, which showed a XO monosomy with a 63,X/64,...
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#2Ottmar DistlH-Index: 31
Last. Julia MetzgerH-Index: 13
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Selection for desirable traits and breed-specific phenotypes has left distinctive footprints in the genome of pigs. As representative of a breed with strong selective traces aiming for robustness, health and performance, the Mangalitza pig, a native curly-haired pig breed from Hungary, was investigated in this study. Whole genome sequencing and SNP chip genotyping was performed to detect runs of homozygosity (ROH) in Mangalitza and Mangalitza-crossbreeds. We identified breed specific ROH regions...
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#1Ann-Kathrin Struck (University of Veterinary Medicine Vienna)H-Index: 1
Last. Ottmar DistlH-Index: 31
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Abstract Amyloidosis in Siamese/Oriental cats is a lethal condition with variable age of clinical onset. There is no sex predisposition and clinical signs of disease usually become apparent by 1–7 years of age. In the terminal stages, the liver is enlarged and pale, and contains parenchymal hemorrhages. In the present study, pedigree data from 17 cats with clinical signs consistent with amyloidosis underwent genetic analysis. Necropsy and histopathological data were available for 10 of the 17 ca...
1 CitationsSource