Susanna Nencetti
University of Pisa
Matrix metalloproteinaseChemical synthesisBiological activityTransthyretinAdrenergicReceptorOrganic chemistryMolecular modelEnzymeChemistryStructure–activity relationshipSteric effectsIn vitroBicyclic moleculeAldose reductaseMoietyOximeArylAdrenergic receptorCancer researchBiochemistryStereochemistryPharmacology
136Publications
18H-index
880Citations
Publications 128
Newest
#1Lidia Ciccone (UniPi: University of Pisa)H-Index: 9
#2Susanna Nencetti (UniPi: University of Pisa)H-Index: 18
Last. Elisabetta Orlandini (UniPi: University of Pisa)H-Index: 20
view all 4 authors...
Neuroglobin (Ngb) is a 17 kDa monomeric hexa-coordinated heme protein belonging to the globin family. Ngb is mainly expressed in neurons of the central and peripheral nervous system, although moderate levels of Ngb have been detected in non-nervous tissues. In the past decade, Ngb has been studied for its neuroprotective role in a large number of neurological disorders such as Alzheimer's disease, Huntington's disease, brain ischemia and hypoxia. This review discusses and summarizes the natural ...
Source
#1Alessio Nocentini (UniFI: University of Florence)H-Index: 26
#2Doretta Cuffaro (UniPi: University of Pisa)H-Index: 5
Last. Claudiu T. Supuran (UniFI: University of Florence)H-Index: 152
view all 8 authors...
The synthesis and carbonic anhydrase (CA; EC 4.2.1.1) activating effects of a series of oxime ether-based amino alcohols towards four human (h) CA isoforms expressed in human brain, hCA I, II, IV a...
2 CitationsSource
#1Nicolo Tonali (Université Paris-Saclay)H-Index: 5
#2Susanna Nencetti (UniPi: University of Pisa)H-Index: 18
Last. Lidia Ciccone (UniPi: University of Pisa)H-Index: 9
view all 4 authors...
1 CitationsSource
#1Lidia CicconeH-Index: 9
#2Nicolo TonaliH-Index: 5
Last. Elisabetta OrlandiniH-Index: 3
view all 5 authors...
Transthyretin (TTR) is a plasma homotetrameric protein that transports thyroxine and retinol. TTR itself, under pathological conditions, dissociates into partially unfolded monomers that aggregate and form fibrils. Metal ions such as Zn2+, Cu2+, Fe2+, Mn2+ and Ca2+ play a controversial role in the TTR amyloidogenic pathway. TTR is also present in cerebrospinal fluid (CSF), where it behaves as one of the major Aβ-binding-proteins. The interaction between TTR and Aβ is stronger in the presence of ...
1 CitationsSource
#1Lidia Ciccone (UniPi: University of Pisa)H-Index: 9
#2Jennifer Vandooren (Rega Institute for Medical Research)H-Index: 18
Last. Elisabetta Orlandini (UniPi: University of Pisa)H-Index: 20
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Several studies have reported neuroprotective effects by natural products. A wide range of natural compounds have been investigated, and some of these may play a beneficial role in Alzheimer's disease (AD) progression. Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, have been implicated in AD. In particular, MMP-2 and MMP-9 are able to trigger several neuroinflammatory and neurodegenerative pathways. In this review, we summarize and discuss existing literature on nat...
2 CitationsSource
#1Susanna Nencetti (UniPi: University of Pisa)H-Index: 18
#2Doretta Cuffaro (UniPi: University of Pisa)H-Index: 5
Last. Elisabetta Orlandini (UniPi: University of Pisa)H-Index: 20
view all 14 authors...
Uveal melanoma (UM) represents an aggressive type of cancer and currently, there is no effective treatment for this metastatic disease. In the last years, histone deacetylase inhibitors (HDACIs) have been studied as a possible therapeutic treatment for UM, alone or in association with other chemotherapeutic agents. Here we synthesised a series of new HDACIs based on the SAHA scaffold bearing an (arylidene)aminoxy moiety. Their HDAC inhibitory activity was evaluated on isolated human HDAC1, 3, 6,...
1 CitationsSource
The most commonly used antidepressant drugs are the serotonin transporter inhibitors. Their effects depend strongly on the selectivity for a single monoamine transporter compared to other amine transporters or receptors, and the selectivity is roughly influenced by the spatial protein structure. Here, we provide a computational study on three human monoamine transporters, i.e., DAT, NET, and SERT. Starting from the construction of hDAT and hNET models, whose three-dimensional structure is unknow...
1 CitationsSource
#1Lidia Ciccone (UniPi: University of Pisa)H-Index: 9
#2Susanna Nencetti (UniPi: University of Pisa)H-Index: 18
Last. Elisabetta Orlandini (UniPi: University of Pisa)H-Index: 20
view all 9 authors...
Abstract Transthyretin (TTR) is a s-sheet-rich homotetrameric protein that transports thyroxine (T4) and retinol both in plasma and in cerebrospinal fluid. TTR also interacts with amyloid-β, playing a protective role in Alzheimer’s disease. Dissociation of the native transthyretin (TTR) tetramer is widely accepted as the critical step in TTR amyloids fibrillogenesis, and is responsible for extracellular deposition of amyloid fibrils. Small molecules, able to bind in T4 binding sites and stabiliz...
1 CitationsSource
#1Lidia Ciccone (UniPi: University of Pisa)H-Index: 9
#2Nicolo Tonali (Université Paris-Saclay)H-Index: 5
Last. Elisabetta Orlandini (UniPi: University of Pisa)H-Index: 20
view all 4 authors...
: Natural compounds, such as plant and fruit extracts have shown neuroprotective effect against neurodegenerative diseases. It has been reported that several natural compounds binding to transthyretin (TTR) can be useful in amyloidosis prevention. TTR is a transporter protein that under physiological condition carries thyroxine (T4) and retinol in plasma and in cerebrospinal fluid (CSF); it also has a neuroprotective role against Alzheimer's disease (AD). However, TTR also is an amyloidogenic pr...
11 CitationsSource
#1Felicia D'Andrea (UniPi: University of Pisa)H-Index: 19
#2Stefania Sartini (UniPi: University of Pisa)H-Index: 20
Last. Susanna Nencetti (UniPi: University of Pisa)H-Index: 18
view all 11 authors...
: Aldose reductase is a key enzyme in the development of long term diabetic complications and its inhibition represents a viable therapeutic solution for people affected by these pathologies. Therefore, the search for effective aldose reductase inhibitors is a timely and pressing challenge. Herein we describe the access to a novel class of oxyimino derivatives, obtained by reaction of a 1,5-dicarbonyl substrate with O-(arylmethyl)hydroxylamines. The synthesised compounds proved to be active agai...
2 CitationsSource