Klaus Scheffler
University of Tübingen
SignalOpticsPhysicsRadiologyBiomedical engineeringMagnetic resonance imagingArtificial intelligenceMedicinal chemistryPsychologyNeuroscienceSteady-state free precession imagingChemistryMaterials scienceAcousticsHuman brainFunctional magnetic resonance imagingComputer visionComputer scienceNuclear magnetic resonanceMedicine
Publications 957
#1Cihan GöksuH-Index: 4
#2Klaus SchefflerH-Index: 76
Last. Axel ThielscherH-Index: 39
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Purpose: Magnetic resonance current density imaging (MRCDI) combines MR brain imaging with the injection of time-varying weak currents (1-2 mA) to assess the current flow pattern in the brain. However, the utility of MRCDI is still hampered by low measurement sensitivity and poor image quality. Methods: We recently introduced a multi-gradient-echo-based MRCDI approach that has the hitherto best documented efficiency. We now advanced our MRCDI approach in three directions and performed phantom an...
#1P Fehling (MPG: Max Planck Society)H-Index: 2
Last. Klaus Scheffler (MPG: Max Planck Society)H-Index: 76
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#1A Loktyushin (MPG: Max Planck Society)H-Index: 5
#2Kai Herz (University of Tübingen)H-Index: 8
Last. Moritz Zaiss (MPG: Max Planck Society)H-Index: 28
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PURPOSE A supervised learning framework is proposed to automatically generate MR sequences and corresponding reconstruction based on the target contrast of interest. Combined with a flexible, task-driven cost function this allows for an efficient exploration of novel MR sequence strategies. METHODS The scanning and reconstruction process is simulated end-to-end in terms of RF events, gradient moment events in x and y, and delay times, acting on the input model spin system given in terms of proto...
2 CitationsSource
Parahydrogen (pH2) is a convenient and cost efficient source for magnetic resonance signal enhancement. Transient interaction of pH2 with a metal organic complex in a signal amplification by reversible exchange (SABRE) experiment enabled more than 10% polarization for some 15N molecules. Here, we analyzed a variant of SABRE, consisting of an outer magnetic field alternating between a low field of ~1 \muT, where a polarization transfer takes place, and a higher field >50 \muT (alt-SABRE). We foun...
#1Nikolai I. Avdievich (MPG: Max Planck Society)H-Index: 20
#2Georgiy Solomakha (Saint Petersburg State University of Information Technologies, Mechanics and Optics)H-Index: 3
Last. Klaus Scheffler (MPG: Max Planck Society)H-Index: 76
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MRI at ultra-high field (UHF, ≥7 T) provides a natural strategy for improving the quality of X-nucleus magnetic resonance spectroscopy and imaging due to the intrinsic benefit of increased signal-to-noise ratio. Considering that RF coils require both local transmission and reception at UHF, the designs of double-tuned coils, which often consist of several layers of transmit and receive resonant elements, become quite complex. A few years ago, a new type of RF coil, ie a dipole antenna, was devel...
#1Boris-Stephan Rauchmann (LMU: Ludwig Maximilian University of Munich)H-Index: 9
#2Ersin Ersoezlue (LMU: Ludwig Maximilian University of Munich)
Last. Robert Perneczky (LMU: Ludwig Maximilian University of Munich)H-Index: 55
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Several Alzheimer's disease (AD) atrophy subtypes were identified, but their brain network properties are unclear. We analyzed data from two independent datasets, including 166 participants (103 AD/63 controls) from the DZNE-longitudinal cognitive impairment and dementia study and 151 participants (121 AD/30 controls) from the AD neuroimaging initiative cohorts, aiming to identify differences between AD atrophy subtypes in resting-state functional magnetic resonance imaging intra-network connect...
#1Klaus Scheffler (MPG: Max Planck Society)H-Index: 76
#2Jörn Engelmann (MPG: Max Planck Society)H-Index: 12
Last. Rahel Heule (MPG: Max Planck Society)H-Index: 10
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PURPOSE To assess the vessel size specificity and sensitivity of rapid CPMG and GRASE for functional BOLD imaging for different echo train lengths, echo spacings, field strength, and refocusing flip angle schemes. In addition, the behavior of signals acquired before and after the refocusing time points is analyzed. METHODS Evolution of magnetization within a network of artificial cylinders is simulated with Monte Carlo methods for all relevant coherence pathways. In addition, measurements on mic...
#1Sreekanth Madhusoodhanan (IIIT: Indian Institutes of Information Technology)H-Index: 2
#2Gisela E. Hagberg (MPG: Max Planck Society)H-Index: 31
Last. Joseph Suresh Paul (UoK: University of Kerala)H-Index: 15
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PURPOSE To develop a spatio-temporal approach to accurately unwrap multi-echo gradient-recalled echo phase in the presence of high-field gradients. THEORY AND METHODS Using the virtual echo-based Nyquist sampled (VENyS) algorithm, the temporal unwrapping procedure is modified by introduction of one or more virtual echoes between the first lower and the immediate higher echo, so as to reinstate the Nyquist condition at locations with high-field gradients. An iterative extension of the VENyS algor...
#1Nikolai I. Avdievich (MPG: Max Planck Society)H-Index: 20
#2Georgiy Solomakha (Saint Petersburg State University of Information Technologies, Mechanics and Optics)H-Index: 3
Last. Klaus Scheffler (MPG: Max Planck Society)H-Index: 76
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The advancement of clinical applications of ultrahigh field (UHF) MRI depends heavily on advances in technology, including the development of new radiofrequency (RF) coil designs. Currently, the number of commercially available 7 T head RF coils is rather limited, implying a need to develop novel RF head coil designs that offer superior transmit and receive performance. RF coils to be used for clinical applications must be robust and reliable. In particular, for transmit arrays, if a transmit ch...
#1Kai Herz (MPG: Max Planck Society)H-Index: 8
#2Sebastian Mueller (MPG: Max Planck Society)H-Index: 5
Last. Moritz Zaiss (MPG: Max Planck Society)H-Index: 28
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PURPOSE As the field of CEST grows, various novel preparation periods using different parameters are being introduced. At the same time, large, multisite clinical studies require clearly defined protocols, especially across different vendors. Here, we propose a CEST definition standard using the open Pulseq format for a shareable, simple, and exact definition of CEST protocols. METHODS We present the benefits of such a standard in three ways: (1) an open database on GitHub, where fully defined, ...