Gaia Scafetta
Sapienza University of Rome
Tree (data structure)Cell therapyEndocrinologyCellular differentiationMesenchymal stem cellProgenitor cellImmunologyT-cell leukemiaPancreasPDX1StreptozotocinPeptideInsulinStem cellCancer researchCell growthMedicinePI3K/AKT/mTOR pathwayBiologyCell biology
19Publications
8H-index
139Citations
Publications 19
Newest
#1Paola Grazioli (Sapienza University of Rome)H-Index: 13
#2Andrea Orlando (IIT: Istituto Italiano di Tecnologia)H-Index: 1
Last. Antonio Francesco Campese (Sapienza University of Rome)H-Index: 25
view all 8 authors...
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive pediatric malignancy that arises from the transformation of immature T-cell progenitors and has no definitive cure. Notch signaling governs many steps of T cell development and its dysregulation represents the most common causative event in the pathogenesis of T-ALL. The activation of canonical NF-κB pathway has been described as a critical downstream mediator of Notch oncogenic functions, through the sustaining of tumor cell survival ...
1 CitationsSource
#1Guido Carpino (Sapienza University of Rome)H-Index: 54
#2Rosa Puca (Sapienza University of Rome)H-Index: 18
Last. Domenico Alvaro (Sapienza University of Rome)H-Index: 75
view all 13 authors...
Peribiliary glands (PBGs) are niches in the biliary tree and containing heterogeneous endodermal stem/progenitors cells that can differentiate, in vitro and in vivo, toward pancreatic islets. The aim of this study was to evaluate, in experimental and human diabetes, proliferation of cells in PBGs and differentiation of the biliary tree stem/progenitor cells (BTSCs) toward insulin-producing cells. Diabetes was generated in mice by intraperitoneal injection of a single dose of 200 mg/kg (N = 12) o...
15 CitationsSource
#1Guido CarpinoH-Index: 54
#2Vincenzo CardinaleH-Index: 36
Last. Domenico AlvaroH-Index: 75
view all 11 authors...
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#1Augusto Carducci (Sapienza University of Rome)H-Index: 2
#2Gaia Scafetta (Sapienza University of Rome)H-Index: 8
Last. Elena De Falco (Sapienza University of Rome)H-Index: 20
view all 14 authors...
Tenon's fibroblasts (TFs), widely employed as in vitro model for many ophthalmological studies, are routinely cultured with FBS. Platelet Lysate (PL), a hemoderivate enriched with growth factors and cytokines has been largely tested in several clinical applications and as substitute of FBS in culture. Here, we investigate whether PL can exert biological effects on TF populations similarly to other cell types. Results show that PL significantly enhances cell proliferation and migration vs. FBS, w...
8 CitationsSource
#1Guido CarpinoH-Index: 54
#2Vincenzo CardinaleH-Index: 36
Last. Domenico AlvaroH-Index: 75
view all 13 authors...
Source
#1Camilla Siciliano (IIT: Istituto Italiano di Tecnologia)H-Index: 10
#2Isotta ChimentiH-Index: 23
Last. Elena De FalcoH-Index: 20
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Nowadays, cardiac regenerative medicine is facing many limitations because of the complexity to find the most suitable stem cell source and to understand the regenerative mechanisms involved. Mesenchymal stem cells (MSCs) have shown great regenerative potential due to their intrinsic properties and ability to restore cardiac functionality, directly by transdifferentiation and indirectly by paracrine effects. Yet, how MSCs could respond to definite cardiac-committing microenvironments, such as th...
19 CitationsSource
#1Vincenzo Cardinale (Sapienza University of Rome)H-Index: 36
#2Rosa Puca (Sapienza University of Rome)H-Index: 18
Last. Domenico Alvaro (Sapienza University of Rome)H-Index: 75
view all 16 authors...
Generation of β-pancreatic cells represents a major goal in research. The aim of this study was to explore a protein-based strategy to induce differentiation of human biliary tree stem cells (hBTSCs) towards β-pancreatic cells. A plasmid containing the sequence of the human pancreatic and duodenal homeobox 1 (PDX1) has been expressed in E. coli. Epithelial-Cell-Adhesion-Molecule positive hBTSCs or mature human hepatocyte cell line, HepG2, were grown in medium to which Pdx1 peptide was added. Dif...
14 CitationsSource
#1Gaia Scafetta (Sapienza University of Rome)H-Index: 8
#2Camilla Siciliano (IIT: Istituto Italiano di Tecnologia)H-Index: 10
Last. Elena De Falco (Sapienza University of Rome)H-Index: 20
view all 4 authors...
: The coculture technique is the standard method to expand ex vivo limbal stem cells (LSCs) by using inactivated embryonic murine feeder layers (3T3). Although alternative techniques such as amniotic membranes or scaffolds have been proposed, feeder layers are still considered to be the best method, due to their ability to preserve some critical properties of LSCs such as cell growth and viability, stemness phenotype, and clonogenic potential. Furthermore, clinical applications of LSCs cultured ...
6 CitationsSource
#1Camilla Siciliano (IIT: Istituto Italiano di Tecnologia)H-Index: 10
#2Mohsen Ibrahim (WashU: Washington University in St. Louis)H-Index: 28
Last. Elena De Falco (Sapienza University of Rome)H-Index: 20
view all 8 authors...
Mesenchymal stem cells (MSCs) are adult multipotent cells currently employed in several clinical trials due to their immunomodulating, angiogenic and repairing features. The adipose tissue is certainly considered an eligible source of MSCs. Recently, putative adipose tissue derived MSCs (ADMSCs) have been isolated from the mediastinal depots. However, very little is known about the properties, the function and the potential of human mediastinal ADMSCs (hmADMSCs). However, the lack of standardize...
24 CitationsSource
#1Vincenzo CardinaleH-Index: 36
#2Gaia ScafettaH-Index: 8
Last. Domenico AlvaroH-Index: 75
view all 12 authors...
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