Ian R. Hart
Queen Mary University of London
CancerInternal medicinePathologyCellMolecular biologyChemistryIntegrinIn vitroImmunologyIn vivoCarcinomaPancreatic cancerCancer researchBreast cancerCell growthMedicineCell cultureBiologyCell biologyCancer cell
113Publications
50H-index
6,703Citations
Publications 113
Newest
#2Naoki KishiH-Index: 2
Last. Stéphanie KermorgantH-Index: 25
view all 17 authors...
Nature Communications 7 Article number:11942 (2016); Published 23 June 2016; Updated 21 July 2016 The original version of this Article contained an error in the spelling of the author Luisa Robbez-Masson, which was incorrectly given as Luisa Robert-Masson. This has now been corrected in both the PDFand HTML versions of the Article.
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#1Rachel Barrow-McGee (QMUL: Queen Mary University of London)H-Index: 4
#2Naoki Kishi (QMUL: Queen Mary University of London)H-Index: 2
Last. Stéphanie KermorgantH-Index: 25
view all 17 authors...
Cooperative signalling between receptor tyrosine kinases (RTKs) and integrins is thought to occur at the cell surface. Here the authors show that β1 integrin influences signalling of an RTK, c-Met, from a novel intracellular compartment they call autophagy-related endomembranes.
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#1Kate M Moore (QMUL: Queen Mary University of London)H-Index: 7
#2Gareth J. Thomas (QMUL: Queen Mary University of London)H-Index: 62
Last. John Marshall (QMUL: Queen Mary University of London)H-Index: 98
view all 28 authors...
BACKGROUND: Integrin ?v?6 promotes migration, invasion, and survival of cancer cells; however, the relevance and role of ?v?6 has yet to be elucidated in breast cancer. METHODS: Protein expression of integrin subunit beta6 (?6) was measured in breast cancers by immunohistochemistry (n > 2000) and ITGB6 mRNA expression measured in the Molecular Taxonomy of Breast Cancer International Consortium dataset. Overall survival was assessed using Kaplan Meier curves, and bioinformatics statistical analys...
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#1Michael D. Allen (QMUL: Queen Mary University of London)H-Index: 13
#2Gareth J. Thomas (University of Southampton)H-Index: 62
Last. J. Louise JonesH-Index: 31
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Purpose: This study investigated the functional and clinical significance of integrin αvβ6 up-regulation in myoepithelial cells of ductal carcinoma in-situ (DCIS). Experimental Design: Archival samples of DCIS and DCIS with associated invasion (n=532) were analysed for expression of αvβ6 by immunohistochemistry, and ability to predict recurrence and progression assessed in an independent, unique cohort of DCIS cases with long term follow up. Primary myoepithelial cells and myoepithelial cell lin...
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s / Pancreatology 13 (2013) e1–e20 e4 postoperative bleeding between the resection groups. There was no difference in resection margin status (R0 in 85 PDVR (37%) and 397 PD (48%) p1⁄40.09). Conclusion: This study demonstrates no significant difference in perioperative mortality in the three groups. It also demonstrates a similar overall survival in the PD and PDVR groups, significantly better compared to SB. The group also comprises C Coldham, A Saleh, A Al-Hilli, G Spoletini, S Aroori, J Hammo...
#1Kate M MooreH-Index: 7
#2Gareth J. ThomasH-Index: 62
Last. John MarshallH-Index: 98
view all 28 authors...
The integrin avβ6 promotes migration, invasion and survival of cancer cells, but the biological relevance has yet to be ascertained in breast cancer. Our immunhistochemical analysis of over 2000 breast cancers has revealed that high expression of the protein for the integrin subunit beta6 (β6) is associated with very poor survival (HR = 1.99, P = 2.9×10-6) and increased metastases to distant sites (P = 0·02). This correlation was confirmed at the mRNA level via bioinformatic analysis of the 2000...
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#1Ningfeng Fiona Li (QMUL: Queen Mary University of London)H-Index: 1
#2Emilios Gemenetzidis (QMUL: Queen Mary University of London)H-Index: 10
Last. Hemant M. Kocher (QMUL: Queen Mary University of London)H-Index: 41
view all 14 authors...
Human pancreatic ductal adenocarcinoma (PDAC) is characterized by early systemic dissemination. Although RhoC has been implicated in cancer cell migration, the relevant underlying molecular mechanisms remain unknown. RhoC has been implicated in the enhancement of cancer cell migration and invasion, with actions which are distinct from RhoA (84% homology), and are possibly attributed to the divergent C-terminus domain. Here, we confirm that RhoC significantly enhances the migratory and invasive p...
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#1Luisa Robbez-Masson (QMUL: Queen Mary University of London)H-Index: 4
#2Csaba Bödör (QMUL: Queen Mary University of London)H-Index: 20
Last. Richard Grose (QMUL: Queen Mary University of London)H-Index: 33
view all 7 authors...
Genome wide association studies have identified single nucleotide polymorphisms (SNP) within fibroblast growth factor receptor 2 (FGFR2) as one of the highest ranking risk alleles in terms of development of breast cancer. The potential effect of these SNPs, in intron two, was postulated to be due to the differential binding of cis-regulatory elements, such as transcription factors, since all the SNPs in linkage disequilibrium were located in a regulatory DNA region. A Runx2 binding site was repo...
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#1Kate M MooreH-Index: 7
#2Gareth J. Thomas (Southampton General Hospital)H-Index: 62
Last. John MarshallH-Index: 98
view all 28 authors...
Background: Integrin αvβ6 promotes migration, invasion and survival of cancer cells, however, the relevance and role of αvβ6 has yet to be elucidated in breast cancer. Methods: Protein expression of integrin subunit beta6 (β6) was measured in over 2000 breast cancers by immunohistochemistry and ITGB6 mRNA expression measured in the METABRIC dataset. Overall survival was assessed using Kaplan-Meier curves and bioinformatics statistical analyses were performed in R statistical environment v2.14.1....
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#1Vassiliki Kostourou (QMUL: Queen Mary University of London)H-Index: 14
#2Tanguy Lechertier (QMUL: Queen Mary University of London)H-Index: 10
Last. Kairbaan Hodivala-Dilke (QMUL: Queen Mary University of London)H-Index: 54
view all 14 authors...
Focal adhesion kinase (FAK) regulates angiogenesis and FAK inhibitors are currently developed as anticancer drugs. Here Kostourou and colleagues show that genetic FAK heterozygosity or low doses of a pharmacological FAK inhibitor unexpectedly increase angiogenesis and tumour growth in vitro and in vivo.
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