Kim Ohl
RWTH Aachen University
ZAP70Internal medicineInterleukin 21Cytotoxic T cellProinflammatory cytokineChemistryImmunologyT cellInflammationArthritisCytokineFOXP3AutoimmunityCAMP-Responsive Element ModulatorLung injuryCancer researchMedicineTranscription factorBiologyImmune systemCell biology
Publications 53
#1Kim Ohl (RWTH Aachen University)H-Index: 16
#2Thomas Rauen (RWTH Aachen University)H-Index: 50
Last. Klaus Tenbrock (RWTH Aachen University)H-Index: 35
view all 3 authors...
#1Anandhi Rajendiran (RWTH Aachen University)H-Index: 1
#2Patricia Klemm (RWTH Aachen University)H-Index: 4
Last. Federica Raggi (LMB: Laboratory of Molecular Biology)H-Index: 11
view all 17 authors...
OBJECTIVE Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease of unknown origin. The regulation of inflammatory processes involves multiple cellular steps including mRNA transcription and translation. Different miRNAs tightly control these processes. We aimed to determine the roles of specific miRNAs within JIA pathogenesis. METHODS We performed a global miRNA expression analysis in parallel in cells from the arthritic joint and peripheral blood of oligoarticular JIA patients a...
#7Mark Klein (University of Mainz)H-Index: 172
Emerging data demonstrate that the activity of immune cells can be modulated by microbial molecules. Here, we show that the short-chain fatty acids (SCFAs) pentanoate and butyrate enhance the anti-tumor activity of cytotoxic T lymphocytes (CTLs) and chimeric antigen receptor (CAR) T cells through metabolic and epigenetic reprograming. We show that in vitro treatment of CTLs and CAR T cells with pentanoate and butyrate increases the function of mTOR as a central cellular metabolic sensor, and inh...
#1Eva Lausberg (RWTH Aachen University)H-Index: 2
#2Sebastian Gießelmann (RWTH Aachen University)H-Index: 1
Last. Florian Kraft (RWTH Aachen University)H-Index: 7
view all 34 authors...
Background Deciphering the function of the many genes previously classified as uncharacterized "open reading frame" (orf) completes our understanding of cell function and its pathophysiology. Methods Whole-exome sequencing, yeast 2-hybrid and transcriptome analyses together with molecular characterization are used here to uncover the function of the C2orf69 gene. Results We identified loss-of-function mutations in the uncharacterized C2orf69 gene in eight individuals with brain abnormalities inv...
#1Kim Ohl (RWTH Aachen University)H-Index: 16
#2Klaus Tenbrock (RWTH Aachen University)H-Index: 35
Oxidative stress is a major component of cellular damage in T cells from patients with systemic lupus erythematosus (SLE) resulting amongst others in the generation of pathogenic Th17 cells. The NRF2/Keap pathway is the most important antioxidant system protecting cells from damage due to oxidative stress. Activation of NRF2 therefore seems to represent a putative therapeutic target in SLE, which is nevertheless challenged by several findings suggesting tissue and cell specific differences in th...
MΦ differentiate from circulating monocytes (Mo). The reduced ability of neonatal Mo to undergo apoptosis after E. coli infection (phagocytosis-induced cell death (PICD)) could contribute to sustained inflammatory processes. The objective of our study was to investigate whether immune metabolism in Mo can be modified to gain access to pro-apoptotic signaling. To this end, we supplemented Mo from neonates and from adults with the branched amino acid leucine. In neonatal Mo, we observed increased ...
Background: Unraveling the function of the many genes that encode for uncharacterized open reading frames (ORFs) is important to understand physiological processes. Methods: By whole exome sequencing, yeast-2-hybrid, transcriptome analysis and molecular characterization we could uncover the cause of an undescribed mitochondriopathy. Results: We identify loss-of-function mutations in the uncharacterized C2orf69 gene in eight individuals with a common phenotype of brain anomalies with hypomyelinat...
#1Svenja Böll (RWTH Aachen University)H-Index: 3
#2Sebastian Ziemann (RWTH Aachen University)H-Index: 1
Last. Eva Verjans (RWTH Aachen University)H-Index: 9
view all 13 authors...
BACKGROUND: Allergic diseases and especially allergic asthma are widespread diseases with high prevalence in childhood, but also in adults. Acid sphingomyelinase (ASM) is a key regulator of the sphingolipid pathway. Previous studies defined the association of ASM with the pathogenesis of TH 1-directed lung diseases like cystic fibrosis and acute lung injury. Here, we define the role of ASM in TH 2-regulated allergic bronchial asthma. METHODS: To determine the role of Asm under baseline condition...
#1Daniel M. Breitkopf (RWTH Aachen University)H-Index: 4
#2Vera Jankowski (RWTH Aachen University)H-Index: 31
Last. Ute Raffetseder (RWTH Aachen University)H-Index: 21
view all 15 authors...
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease and lupus nephritis bares is a major risk for morbidity and mortality. Notch-3 signaling induced by membrane-bound or soluble ligands such as YB-1 constitutes an evolutionary conserved pathway that determines major decisions in cell fate. Mass spectrometry of extracellular YB-1 in sera from patients with SLE and lupus-prone mice revealed specific post-translational guanidinylation of two lysine residues within the highly conser...
#1Stephan Dreschers (Boston Children's Hospital)H-Index: 7
#2Kim Ohl (RWTH Aachen University)H-Index: 16
Last. Thorsten W. Orlikowsky (Boston Children's Hospital)H-Index: 16
view all 5 authors...
Neonatal sepsis is accompanied by impaired apoptotic depletion of monocytes and macrophages (MΦ), aberrant cytokine production, impaired cell metabolism, and sustained inflammation. Macrophage-colony stimulating factor (M-CSF) triggers the differentiation from monocytes into MΦ (MΦ-0). Interleukin-10 (IL10) and Interferon-gamma (IFNy) further differentiate MΦ subpopulations, the anti-inflammatory MΦ-IL10 and the pro-inflammatory MΦ-IFNy subtype. We previously have shown significant differences b...
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