Andrea Masotti
Boston Children's Hospital
GeneInternal medicinemicroRNAGene expressionNanotechnologyChemistryMaterials scienceImmunologyMicrovesiclesDiseasePathogenesisCancer researchGeneticsBiochemistryBioinformaticsRNAComputational biologyMedicineBiologyCell biology
Publications 142
#1Milad BastamiH-Index: 12
#2Andrea Masotti (Boston Children's Hospital)H-Index: 31
Last. Ziba Nariman-Saleh-Fam (Tabriz University of Medical Sciences)H-Index: 12
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Abstract null null MicroRNAs (miRNAs) have emerged as a critical component of regulatory networks that modulate and fine-tune gene expression in a post-transcriptional manner. The microRNA-196 family is encoded by three loci in the human genome, namely hsa-mir-196a-1, hsa-mir-196a-2, and hsa-mir-196b. Increasing evidence supports the roles of different components of this miRNA family in regulating key cellular processes during differentiation and development, ranging from inflammation and differ...
#1Roberta Ferretti (Boston Children's Hospital)
#2Antonella Baldassarre (Boston Children's Hospital)H-Index: 10
Last. Maria Vinci (Boston Children's Hospital)H-Index: 9
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3D models are increasingly used to study mechanisms driving tumor progression and mimicking in vitro processes such as invasion and migration. However, there is a need to establish more protocols based on 3D culture systems that allow for downstream molecular biology investigations. Materials & methods: Here we present a method for optimal RNA extraction from highly aggressive primary glioma cells invading into Matrigel. The method has been established by comparing previously reported protocols,...
#1Sara Ahmadi Badi (Pasteur Institute of Iran)H-Index: 8
#2Samira Tarashi (Pasteur Institute of Iran)H-Index: 7
Last. Seyed Davar Siadat (Pasteur Institute of Iran)H-Index: 20
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Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is responsible for the outbreak of a new viral respiratory infection. It has been demonstrated that the microbiota has a crucial role in establishing immune responses against respiratory infections, which are controlled by a bidirectional cross-talk, known as the “gut-lung axis.” The effects of microbiota on antiviral immune responses, including dendritic cell (DC) function and lymphocyte homing in the gut-lung axis, have been reported...
#1Giulia Pericoli (Boston Children's Hospital)
#2Angela Galardi (Boston Children's Hospital)H-Index: 6
Last. Maria Vinci (Boston Children's Hospital)H-Index: 9
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#1Lucia Lisa Petrilli (Boston Children's Hospital)H-Index: 7
#2Alessandro Paolini (Boston Children's Hospital)H-Index: 9
Last. Maria Vinci (Boston Children's Hospital)H-Index: 9
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#1Manlio VinciguerraH-Index: 45
#2Andrea MasottiH-Index: 31
Last. Anna AlisiH-Index: 58
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1 CitationsSource
#2Alessandro PaoliniH-Index: 9
Last. Andrea MasottiH-Index: 31
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After the increasing number of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections all over the world, researchers and clinicians are struggling to find a vaccine or innovative therapeutic strategies to treat this viral infection. The severe acute respiratory syndrome coronavirus infection that occurred in 2002, Middle East respiratory syndrome (MERS) and other more common infectious diseases such as hepatitis C virus, led to the discovery of many RNA-based drugs. Among them,...
9 CitationsSource
#1Meysam Sarshar (Sapienza University of Rome)H-Index: 12
#2Daniela Scribano (Sapienza University of Rome)H-Index: 12
Last. Andrea Masotti (Boston Children's Hospital)H-Index: 31
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Over the past decade, short non-coding microRNAs (miRNAs), including circulating and fecal miRNAs have emerged as important modulators of various cellular processes by regulating the expression of target genes. Recent studies revealed the role of miRNAs as powerful biomarkers in disease diagnosis and for the development of innovative therapeutic applications in several human conditions, including intestinal diseases. In this review, we explored the literature and summarized the role of identifie...
10 CitationsSource
#1Elham Aghamohamadi (Semnan University)
#2Parviz Kokhaei (Semnan University)H-Index: 20
Last. Mohammad Reza Zali (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 61
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Background and Aims: Interleukin-15 (IL-15) is a key player in the pathogenesis of celiac disease (CD). We investigated the functional role of IL-15 in the process of epithelial cell phenotypic mod...
#1Catriona H. Edwards (Aberd.: University of Aberdeen)H-Index: 2
#2Craig R. Christie (Aberd.: University of Aberdeen)H-Index: 2
Last. Ewan M. Campbell (Aberd.: University of Aberdeen)H-Index: 17
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In this study, the use of dendrimer-coated carbon nanotubes (CNTs) as a delivery vehicle for dsRNA was assessed in Tribolium castaneum. Exposure to low dosages of polyamidoamine dendrimer carbon nanotubes (PAMAM-CNTs) did not affect T. castaneum larval mortality. Expression of key apoptotic factors, Dronc (Tc12580), Dredd (Tcn-like, Tc014026) and Buffy, (Tcinhib apop1), which can act as toxicity indicators, were not altered in T. castaneum larvae following injection of PAMAM-CNTs. The level of k...
3 CitationsSource