Antonio Moschetta
University of Bari
Internal medicineEndocrinologyLiver X receptorReceptorChemistryFarnesoid X receptorInflammationGallbladderCholesterolDiseaseBile acidMetabolic syndromeIntestinal epitheliumG protein-coupled bile acid receptorLipid metabolismCancer researchBiochemistryNuclear receptorMedicineBiologyGastroenterologyCell biology
187Publications
52H-index
9,423Citations
Publications 166
Newest
#1Stefania De Santis (University of Bari)H-Index: 13
#2Marina LisoH-Index: 8
Last. Maria Lisa Clodoveo (University of Bari)H-Index: 25
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Extra virgin olive oil (EVOO) represents one of the most important health-promoting foods whose antioxidant and anti-inflammatory activities are mainly associated to its polyphenols content. To date, studies exploring the effect of EVOO polyphenols on dendritic cells (DCs), acting as a crosstalk between the innate and the adaptive immune response, are scanty. Therefore, we studied the ability of three EVOO extracts (cv. Coratina, Cima di Mola/Coratina, and Casaliva), characterized by different p...
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#1Lucilla Crudele (University of Bari)H-Index: 4
#2Elena Piccinin (University of Bari)H-Index: 10
Last. Antonio Moschetta (University of Bari)H-Index: 52
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The prevalence of being overweight and obese has been expanded dramatically in recent years worldwide. Obesity usually occurs when the energetic introit overtakes energy expenditure from metabolic and physical activity, leading to fat accumulation mainly in the visceral depots. Excessive fat accumulation represents a risk factor for many chronic diseases, including cancer. Adiposity, chronic low-grade inflammation, and hyperinsulinemia are essential factors of obesity that also play a crucial ro...
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Antibiotics that inhibit bacterial protein or nucleic acid synthesis and function can exert an off-target action on mitochondria (mitotoxic antibiotics), making actively dividing mammalian cells dependent on uridine and pyruvate supplementation. Based on this rationale, we carried out, for the first time, a randomized pilot study in 55 patients with asymptomatic bacteriuria or positive sperm culture, each treated with a single mitotoxic antibiotic with or without oral supplementation of uridine ...
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#1Annalisa Contursi (University of Bari)H-Index: 7
#1Annalisa Contursi (University of Bari)
Last. Elena Piccinin (University of Bari)H-Index: 10
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The crypt-villus axis represents the essential unit of the small intestine, which integrity and functions are fundamental to assure tissue and whole-body homeostasis. Disruption of pathways regulating the fine balance between proliferation and differentiation results in diseases development. Nowadays, it is well established that microRNAs (miRNAs) play a crucial role in the homeostasis maintenance and perturbation of their levels may promote tumor development. Here, by using microarray technolog...
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#1Elena Piccinin (University of Bari)H-Index: 10
#2Marica Cariello (University of Bari)H-Index: 14
Last. Antonio Moschetta (University of Bari)H-Index: 52
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Colorectal cancer (CRC) is one of the most commonly occurring cancers worldwide. Although several genetic alterations have been associated with CRC onset and progression, nowadays the reprogramming of cellular metabolism has been recognized as a fundamental step of the carcinogenic process. Intestinal tumor cells frequently display an aberrant activation of lipid metabolism. Indeed, to satisfy the growing needs of a continuous proliferation, cancer cells can either increase the uptake of exogeno...
1 CitationsSource
#1Elena Piccinin (University of Bari)H-Index: 10
#2Anna Maria Sardanelli (University of Bari)H-Index: 27
Last. Gaetano Villani (University of Bari)H-Index: 24
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Parkinson’s disease is one of the most common neurodegenerative disorders worldwide, characterized by a progressive loss of dopaminergic neurons mainly localized in the substantia nigra pars compacta. In recent years, the detailed analyses of both genetic and idiopathic forms of the disease have led to a better understanding of the molecular and cellular pathways involved in PD, pointing to the centrality of mitochondrial dysfunctions in the pathogenic process. Failure of mitochondrial quality c...
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#1Marica Cariello (University of Bari)H-Index: 14
#2Roberto De Salvia (University of Bari)H-Index: 6
Last. Antonio Moschetta (University of Bari)H-Index: 52
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Abstract Aims Coronary artery disease (CAD) is described as a range of clinical conditions including myocardial infarction (MI) and unstable angina. Lipid and apolipoprotein profiles together with the study of cholesterol deposit and efflux serve to identify novel pre and post infarct scenarios for the treatment of these patients. In (non-ST elevation myocardial infarction) NSTEMI patients, we analysed both systemic and intracoronary serum ability to accept cholesterol as well as cholesterol eff...
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#1Roberta ZerlotinH-Index: 3
#2Maria ArconzoH-Index: 2
Last. Antonio MoschettaH-Index: 52
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The process of self-renewal in normal intestinal epithelium is characterized by a fine balance between proliferation, differentiation, migration, and cell death. When even one of these aspects escapes the normal control, cellular proliferation and differentiation are impaired, with consequent onset of tumorigenesis. In humans, colorectal cancer (CRC) is the main pathological manifestation of this derangement. Nowadays, CRC is the world’s fourth most deadly cancer with a limited survival after tr...
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#1Marica Cariello (University of Bari)H-Index: 14
#2Elena Piccinin (University of Bari)H-Index: 10
Last. Antonio Moschetta (University of Bari)H-Index: 52
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Abstract Non-Alcoholic Fatty Liver Disease (NAFLD) comprises a wide spectrum of liver injuries from simple steatosis to steatohepatitis and cirrhosis. Non-Alcoholic Steatohepatitis (NASH) is defined when liver steatosis is associated with inflammation, hepatocyte damage and fibrosis. Genetic predisposition and environmental insults (i.e. dietary habits, obesity) are putative responsible for NASH progression. Here, we present the impact of the lipid-sensing nuclear receptors in the pathogenesis a...
1 CitationsSource
#1Maria Arconzo (University of Bari)H-Index: 2
#2Elena Piccinin (University of Bari)H-Index: 10
Last. Antonio Moschetta (University of Bari)H-Index: 52
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Non-alcoholic fatty liver disease (NAFLD) is a global condition characterized by an accumulation of lipids in the hepatocytes. NAFLD ranges from simple steatosis, a reversible and relatively benign condition, to fibrosis with non-alcoholic steatohepatitis (NASH), potentially leading to cirrhosis and hepatocarcinoma. NAFLD can increase the susceptibility to severe liver injury with eventual acute liver failure induced by specific hepatotoxic drugs, including acetaminophen (APAP), which is commonl...
3 CitationsSource