Ron Ofri
Hebrew University of Jerusalem
ErgAnatomyOphthalmologyOptometryInternal medicineSurgeryPathologyGene expressionNeuroscienceElectrophysiologyNeuroprotectionOcular hypertensionRetinaRetinal ganglion cellAchromatopsiaGlaucomaElectroretinographyRetinal detachmentRetinalIntraocular pressureVitreous chamberApplanation tonometryAnesthesiaVeterinary medicinePhotopic visionMedicineBiology
137Publications
22H-index
1,629Citations
Publications 135
Newest
#1Maya Ross (HUJI: Hebrew University of Jerusalem)H-Index: 2
#2Ron Ofri (HUJI: Hebrew University of Jerusalem)H-Index: 22
Inherited retinal degenerations are a leading and untreatbale cause of blindness, and as such they are targets for gene therapy. Numerous gene therapy treatments have progressed from laboratory research to clinical trails, and a pioneering gene therapy received the first ever FDA approval for treating patients. However, currently retinal gene therapy mostly involves subretinal injection of the therapeutic agent, which treats a limited area, entails retinal detachment and other potential complica...
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#1Maya Ross (HUJI: Hebrew University of Jerusalem)H-Index: 2
#2Nili Avni-MagenH-Index: 4
Last. Ron Ofri (HUJI: Hebrew University of Jerusalem)H-Index: 22
view all 5 authors...
PURPOSE To evaluate the effect of prophylactic anti-malarial chloroquine treatment, and its cessation, on electroretinographic (ERG) responses of captive African penguins. METHODS A brief ERG protocol ("QuickRetCheck") was recorded under mesopic conditions with manual restraint and no sedation or pupil dilation. Birds were recorded on two separate occasions, first while being treated with a daily chloroquine dose of 10 mg/kg for 12 days (n = 15, treatment group) and second after 4 months without...
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#1Michala de Linde Henriksen (CSU: Colorado State University)H-Index: 5
#2Ron Ofri (HUJI: Hebrew University of Jerusalem)H-Index: 22
Last. Richard R. Dubielzig (UW: University of Wisconsin-Madison)H-Index: 39
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PURPOSE Review octopus ocular anatomy and describe the histopathologic findings in three octopuses diagnosed with phakitis and retinitis. ANIMALS Two common octopuses (Octopus vulgaris) and one giant Pacific octopus (Enteroctopus dofleini) with a history of ophthalmic disease. METHODS A literature search was performed for the ocular anatomy section. Both eyes from all three octopuses, and two control eyes, were submitted for histopathologic evaluation. Hematoxylin and eosin stain was used for st...
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#1Arianne Pontes Oriá (UFBA: Federal University of Bahia)H-Index: 11
#2Alessandra Estrela-Lima (UFBA: Federal University of Bahia)H-Index: 10
Last. Ron Ofri (HUJI: Hebrew University of Jerusalem)H-Index: 22
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We describe a case of chronic ocular trauma that resulted in fixed and free-floating, pigmented epithelial iridociliary cysts, inflammation, and secondary glaucoma in a caiman (Caiman latirostris). A 20- to 25-year-old male caiman was presented with phthisis bulbi in the right eye, and congested episcleral vessels, corneal leukoma, disorganized anterior chamber, multifocal anterior synechia, and elevated intraocular pressure in the left eye. Ocular ultrasound of the left eye revealed round struc...
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#1Oren Pe'er (HUJI: Hebrew University of Jerusalem)H-Index: 2
Last. Ron Ofri (HUJI: Hebrew University of Jerusalem)H-Index: 22
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PURPOSE To determine whether the order of intraocular pressure (IOP) measurement affects readings, regardless of which eye is measured first. METHODS Intraocular pressure was measured in 31 and 41 dogs using applanation and rebound tonometry, respectively. Initially, IOP was measured in the first (randomly chosen) eye (reading A), followed by measurement in the fellow eye (reading B), and a third (repeated) measurement in the first eye (reading C). After 15 minutes, measurements were repeated in...
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#1Arianne Pontes Oriá (UFBA: Federal University of Bahia)H-Index: 11
#2Danielle Nascimento Silva (UFBA: Federal University of Bahia)H-Index: 2
Last. Ron Ofri (HUJI: Hebrew University of Jerusalem)H-Index: 22
view all 9 authors...
A captive loggerhead turtle (Caretta caretta) of unknown sex, 3 years of age, presented with bilateral mucoid secretions, severe chemosis, conjunctival hyperemia, and globe retraction. The animal was evaluated ophthalmologically and systemically, and hematological, microbiological, and conjunctival cytological and biopsy samples were collected for complementary diagnosis. The histopathological examination showed amphophilic intranuclear inclusions associated with severe inflammatory infiltrate. ...
1 CitationsSource
#1Maya Ross (HUJI: Hebrew University of Jerusalem)H-Index: 2
#2Ron Ofri (HUJI: Hebrew University of Jerusalem)H-Index: 22
Last. Liat Gantz (Vision-Sciences, Inc.)H-Index: 6
view all 14 authors...
Achromatopsia is an inherited retinal disease characterized by loss of cone photoreceptor function. Day blind CNGA3 mutant Improved Awassi sheep provide a large animal model for achromatopsia. This study measured refractive error and axial length parameters of the eye in this model and evaluated chromatic pupillary light reflex (cPLR) testing as a potential screening test for loss of cone function. Twenty-one CNGA3 mutant, Improved Awassi, 12 control Afec-Assaf and 12 control breed-matched wild-...
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#1Maya Ross (HUJI: Hebrew University of Jerusalem)H-Index: 2
#2Alexey Obolensky (HUJI: Hebrew University of Jerusalem)H-Index: 19
Last. Ron Ofri (HUJI: Hebrew University of Jerusalem)H-Index: 22
view all 12 authors...
Gene augmentation therapy based on subretinal delivery of Adeno-Associated Viral (AAV) vectors is proving to be highly efficient in treating several inherited retinal degenerations. However, due to potential complications and drawbacks posed by subretinal injections, there is a great impetus to find alternative methods of delivering the desired genetic inserts to the retina. One such method is an intravitreal delivery of the vector. Our aim was to evaluate the efficacy of two capsid modified vec...
2 CitationsSource
#1Oren Pe'er (HUJI: Hebrew University of Jerusalem)H-Index: 2
#2Liron D Oron (HUJI: Hebrew University of Jerusalem)H-Index: 2
Last. Ron Ofri (HUJI: Hebrew University of Jerusalem)H-Index: 22
view all 3 authors...
PURPOSE: Retrospectively evaluate prognostic indicators and outcome in dogs undergoing temporary tarsorrhaphy following traumatic proptosis. METHODS: Medical records (2004-2017) were reviewed for signalment, cause and duration of proptosis, and clinical findings on admission. The operating faculty member, post-operative medications, and ophthalmic findings at last recheck were recorded. Owners of dogs with blinded eyes were surveyed regarding final outcome and satisfaction. Data were analyzed us...
1 CitationsSource
#1Ron Ofri (HUJI: Hebrew University of Jerusalem)H-Index: 22
#2Björn Ekesten (SLU: Swedish University of Agricultural Sciences)H-Index: 15
OBJECTIVE: Our aim was to generate baseline optical coherence tomography (OCT) measurements of retinal thickness in female Beagles and to determine how these are affected by meridian, eccentricity, and age. METHODS: Twenty-three female Beagles, including six puppies ( 11 years old) were studied. Both retinas of each dog were scanned (in 4 principal meridians) using the Heidelberg Spectralis following ophthalmic examination, refraction, and sedation. In each eye and each meridian, total retinal, ...
3 CitationsSource