Michael P. Shakarjian
RMIT University
Matrix metalloproteinaseMolecular biologyGABAA receptorChemistryImmunologyIn vivoSuperoxide dismutaseMechanism of actionOxidative stressDiazepamGelatinase AGelatinaseWestern blotInflammationTetramethylenedisulfotetramineKeratinocyteRodenticideStatus epilepticusDermisAntioxidantBenzodiazepineNitrogen mustardConvulsantCatalaseNeurotoxicityLamininGSTA4Sulfur mustardLipid peroxidationp38 mitogen-activated protein kinasesElectroencephalographyGlutathioneBiochemistrySignal transductionNMDA receptorMedicineBiologyCell biologyPharmacology
34Publications
12H-index
596Citations
Publications 27
Newest
#1Marcela Laukova (RMIT: RMIT University)H-Index: 15
#2Jana Velíšková (NYMC: New York Medical College)H-Index: 34
Last. Michael P. Shakarjian (RMIT: RMIT University)H-Index: 12
view all 4 authors...
Abstract Tetramethylenedisulfotetramine (tetramine, TETS, TMDT) is a seizure-producing neurotoxic chemical formed by the condensation of sulfamide and formaldehyde. Serendipitously discovered through an occupational exposure in 1949, it was promoted as a rodenticide but later banned worldwide due to its danger to human health. However, exceptional activity of the agent against rodent pests resulted in its clandestine manufacture with large numbers of inadvertent, intentional, and mass poisonings...
8 CitationsSource
#1Marcela Laukova (RMIT: RMIT University)H-Index: 15
#2Sundas Pervez (RMIT: RMIT University)H-Index: 1
Last. Michael P. Shakarjian (RMIT: RMIT University)H-Index: 12
view all 6 authors...
Abstract Tetramethylenedisulfotetramine (TMDT) is a synthetic neurotoxic rodenticide and potential chemical threat agent. Signs of TMDT poisoning include convulsions which can progress into status epilepticus and death. Although clinical reports clearly show that poisoning via food and drink is the main route of exposure, experimental studies have primarily utilized parenteral routes. Here we used two different modes of oral administration of TMDT and compared the toxic outcomes with two differe...
4 CitationsSource
#1Marcela Laukova (NYMC: New York Medical College)H-Index: 15
#2Jana VelíškováH-Index: 34
Last. Michael P. Shakarjian (RMIT: RMIT University)H-Index: 12
view all 4 authors...
: Tetramethylenedisulfotetramine (TMDT) is a synthetic neurotoxic rodenticide considered a chemical threat agent. Symptoms of intoxication include seizures leading to status epilepticus and death. While children and women have been often the victims, no studies exist investigating the neurotoxic effects of TMDT in developing individuals or females. Thus, we performed such an investigation in developing Sprague-Dawley rats of both sexes in order to identify potential age- or sex-dependent vulnera...
6 CitationsSource
#1Marcela LaukovaH-Index: 15
#2Sundas PervezH-Index: 1
Last. Michael P. ShakarjianH-Index: 12
view all 6 authors...
#1Jana Velíšková (NYMC: New York Medical College)H-Index: 34
#2Michael P. Shakarjian (NYMC: New York Medical College)H-Index: 12
Last. Libor Velíšek (NYMC: New York Medical College)H-Index: 27
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Abstract This chapter reviews models of generalized seizures induced by systemic administration of chemical agents in adult rodents. Models of acute seizures induced by chemoconvulsants still represent a valuable research tool used for screening of putative antiseizure drugs, in the toxicology research investigating convulsant properties of naturally occurring and man-made toxins, as well as for studies on mechanisms of action of these convulsant drugs. Models using drugs affecting GABA-A recept...
5 CitationsSource
#1Michael P. Shakarjian (RU: Rutgers University)H-Index: 12
#2Marcela Laukova (NYMC: New York Medical College)H-Index: 15
Last. Libor Velíšek (NYMC: New York Medical College)H-Index: 27
view all 6 authors...
Incidences of pesticide poisonings are a significant cause of morbidity and mortality worldwide. The seizure-inducing rodenticide tetramethylenedisulfotetramine is one of the most toxic of these agents. Although banned, it has been responsible for thousands of accidental, intentional, and mass poisonings in mainland China and elsewhere. An optimal regimen for treatment of poisoning has not been established. Its facile synthesis from easily obtained starting materials, extreme potency, and lack o...
3 CitationsSource
#1Ronald G. Udasin (RU: Rutgers University)H-Index: 3
#2Xia Wen (RU: Rutgers University)H-Index: 14
Last. Jeffrey D. Laskin (RU: Rutgers University)H-Index: 69
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Sulfur mustard and nitrogen mustard (mechlorethamine, HN2) are potent vesicants developed as chemical warfare agents. These electrophilic, bifunctional alkylating agents cause skin injury, including inflammation, edema, and blistering. HN2 covalently modifies macromolecules such as DNA, RNA, and proteins or is scavenged by glutathione, forming adducts that can contribute to toxicity. Multidrug resistance-associated protein 1 (Mrp1/MRP1) is a transmembrane ATPase known to efflux glutathione-conju...
14 CitationsSource
#1Michael P. Shakarjian (RU: Rutgers University)H-Index: 12
#2Mahil S. Ali (NYMC: New York Medical College)H-Index: 1
Last. Libor Velíšek (NYMC: New York Medical College)H-Index: 27
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Abstract The synthetic rodenticide, tetramethylenedisulfotetramine (TMDT), is a persistent and highly lethal GABA-gated Cl− channel blocker. TMDT is clandestinely produced, remains popular in mainland China, and causes numerous unintentional and deliberate poisonings worldwide. TMDT is odorless, tasteless, and easy to manufacture, features that make it a potential weapon of terrorism. There is no effective treatment. We previously characterized the effects of TMDT in C57BL/6 mice and surveyed ef...
16 CitationsSource
#4Robert P. Casillas (Battelle Memorial Institute)H-Index: 20
This chapter describes the dermal toxicity events of the alkylating agent, sulfur mustard [bis(2-chloroethyl) sulfide], which ultimately causes detachment of the epidermis from the dermis. Skin exposure to sulfur mustard (SM) starts a series of dermal toxicity events with severity determined in part by mediators of injury that regulate inflammation, immune responses, apoptosis, necrosis, and a number of signaling pathways. This complex series of events involves a host of normal skin responses to...
4 CitationsSource
#1Michael P. Shakarjian (NYMC: New York Medical College)H-Index: 12
#2Mahil S. Ali (NYMC: New York Medical College)H-Index: 1
Last. Libor Velíšek (NYMC: New York Medical College)H-Index: 27
view all 5 authors...
The synthetic rodenticide, tetramethylenedisulfotetramine (TMDT), is a persistent and lethal GABAA Cl- channel antagonist. Although banned, TMDT is clandestinely produced, remains popular in Mainla...
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