Lucia Cenci
University of Verona
AnalyteSurface plasmon resonanceBinding siteSelectivityDetection limitBiophysicsNanoparticleBiosensorMass spectrometryMolecularly imprinted polymerMonomerBoleteNanotechnologyChemistryMaterials scienceEpitopeTransferrinHepcidinDerivatizationPeptideBoletus edulisCapillary electrophoresisMolecular imprintingChromatographyBiochemistryHormoneDissociation constantPrecipitation polymerization
19Publications
9H-index
178Citations
Publications 19
Newest
#1Lucia Cenci (University of Verona)H-Index: 9
#2Roberta Tatti (University of Verona)H-Index: 2
Last. Alessandra Bossi (University of Verona)H-Index: 28
view all 6 authors...
Abstract Molecularly imprinted polymeric nanogels (nanoMIPs) are soft biomimetics with recognition properties similar to antibodies but robustness and integrability to devices (sensing, assays) typical of polymers. Aiming at tailor-made at-will the recognition and physical properties of these biomimetics, we investigated the process of stamping analytes of clinical relevance, i.e. an idiotipic peptide of Troponin I, on protein-compatible soft-material at the nanoscale. Highly crosslinked poly(ac...
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#1Giacomo Musile (University of Verona)H-Index: 9
#2Lucia Cenci (University of Verona)H-Index: 9
Last. Federica Bortolotti (University of Verona)H-Index: 22
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Abstract The aim of the present work was to develop a novel in-house mixed-mode SPE sorbent to be used for the HPLC-Ion TrapMS determination of 16 basic drugs in urine. By using a computational modelling, a virtual monomer library was screened identifying three suitable functional monomers, methacrylic acid (MAA), itaconic acid (IA) and 2-acrylamide-2-methylpropane sulfonic acid (AMPSA), respectively. Three different sorbents were then synthetized based on these monomers, and using as cross-link...
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#1Alessandra BossiH-Index: 28
#2Lucia CenciH-Index: 9
Last. Riccardo TognatoH-Index: 1
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The combination of nanomaterials, with their specific and particular physico-chemical properties, with the selective recognition abilities of molecularly imprinted polymers (MIPs) yields nano-composites that could find application in a variety of areas, from micro-electronics to analytical chemistry and to nano-medicine. Herein, the integration of nanomaterials to MIPs is discussed with particular attention paid to magnetic nanomaterials and conductive nanotubes. The derivatization methods are i...
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#1Lucia Cenci (University of Verona)H-Index: 9
#2Chiara Piotto (University of Trento)H-Index: 6
Last. Alessandra Bossi (University of Verona)H-Index: 28
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Abstract Nanosized Molecularly Imprinted Polymers (nanoMIPs) are designed artificial nanoreceptors with a predetermined selectivity and specificity for a given analyte, lately proposed as a replacement to antibodies in immunoassays. The nanoMIP-plate preparation based on nanoparticle adsorption was studied with the aim to rationally identify and discuss the critical points in the nanoMIP-assay development, in an example based on the iron homeostasis biomarker hepcidin and hepcidin-specific nanoM...
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#1Lucia Cenci (University of Verona)H-Index: 9
#2Maddalena Bertolla (University of Trento)H-Index: 2
Last. Alessandra Bossi (University of Verona)H-Index: 28
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The integration of molecularly imprinted polymers (MIPs) with MALDI-TOF mass spectrometry (MS) combines MIP selectivity with MS sensitivity. Whether the size of the MIP material—micro versus nano—has an effect on the MS analysis was the object of the study. MIPs, targeting respectively the epitope peptide NR11 of cardiac troponin I and the peptide CK13 of human serum transferrin, were synthesized and characterized. The size-related performance of the MIP materials hyphenated with MALDI-TOF-MS an...
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#1Maddalena Bertolla (University of Trento)H-Index: 2
#2Lucia Cenci (University of Verona)H-Index: 9
Last. Alessandra Bossi (University of Verona)H-Index: 28
view all 8 authors...
Molecular imprinted poly(acrylamido)-derivative nanogels have shown their selectivity to bind the protein human serum transferrin (HTR) and also showed their capability for instantaneous solvent-induced modification upon the addition of acetonitrile. Integrated to matrix-assisted laser desorption/ionization time-of-flight mass analysis the HTR-imprinted solvent-responsive nanogels permitted the determination of HTR straight from serum and offered novel perspectives in targeted protein analysis.
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#1Lucia Cenci (University of Verona)H-Index: 9
#2Graziano Guella (University of Trento)H-Index: 40
Last. Alessandra Bossi (University of Verona)H-Index: 28
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A biomimetic route towards assisted folding was explored. Molecularly imprinted polymeric nanoparticles (MIP NPs), i.e. biomimetics with entailed molecular recognition properties made by a template assisted synthesis, were prepared to target a structured epitope: the cystine containing peptide CC9ox, which corresponds to the apical portion of the β-hairpin hormone Hepcidin-25. The structural selection was achieved by the MIP NPs; moreover, the MIP NPs demonstrated favouring the folding of the li...
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#1Giacomo Musile (University of Verona)H-Index: 9
#2Lucia Cenci (University of Verona)H-Index: 9
Last. Alessandra Bossi (University of Verona)H-Index: 28
view all 6 authors...
In response to the need for straightforward analytical methods to assess the affinity of molecularly imprinted nanoparticles (MIP NPs) for ligands, capillary electrophoresis (CE) was exploited using MIP NPs targeting the iron-regulating hormone hepcidin. In this work, MIP NPs were challenged with their template peptide, i.e., the N-terminal 5-mer of hepcidin, in comparison to unrelated ligand peptides. A CE separation method was developed ex novo achieving, after optimization of the background e...
Source
#1Lucia CenciH-Index: 9
#2Giacomo MusileH-Index: 9
Last. Alessandra BossiH-Index: 28
view all 4 authors...
#1Lucia CenciH-Index: 9
#2Domenico GirelliH-Index: 81
Last. Alessandra BossiH-Index: 28
view all 3 authors...
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