Shigeru Yatoh
University of Tsukuba
Internal medicineEndocrinologyLipogenesisGene expressionWhite adipose tissueMolecular biologyAdipose tissueChemistryPeroxisome proliferator-activated receptorType 2 diabetesInsulin resistanceCholesterolInsulinSterol Regulatory Element Binding Protein 1Lipid metabolismDiabetes mellitusMedicineSterol regulatory element-binding proteinTranscription factorBiologyCell biology
51Publications
22H-index
1,697Citations
Publications 52
Newest
#1Manabu Midorikawa (University of Tsukuba)
#2Hiroaki Suzuki (University of Tsukuba)H-Index: 50
Last. Shigeru Yatoh (University of Tsukuba)H-Index: 22
view all 14 authors...
Aim. We investigated the relationship between cognitive function and olfactory and physical functions in middle-aged persons with and without type 2 diabetes (T2D) to examine the potential of olfactory and physical functions as biomarkers for early cognitive impairment. Methods. Enrolled were 70 T2D patients (age 40 to <65 y) and 81 age-matched control participants without diabetes. Cognitive function was assessed by the Montreal Cognitive Assessment (MoCA), Trail Making Test parts A and B (TMT-...
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#1Motohiro Sekiya (University of Tsukuba)H-Index: 29
#2Takaaki Matsuda (University of Tsukuba)H-Index: 2
Last. Hitoshi Shimano (University of Tsukuba)H-Index: 88
view all 13 authors...
BACKGROUND: Renal hypouricemia (RHUC) is a hereditary disorder where mutations in SLC22A12 gene and SLC2A9 gene cause RHUC type 1 (RHUC1) and RHUC type 2 (RHUC2), respectively. These genes regulate renal tubular reabsorption of urates while there exist other genes counterbalancing the net excretion of urates including ABCG2 and SLC17A1. Urate metabolism is tightly interconnected with glucose metabolism, and SLC2A9 gene may be involved in insulin secretion from pancreatic beta-cells. On the other...
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#1Takashi Matsuzaka (University of Tsukuba)H-Index: 41
#2Motoko Kuba (University of Tsukuba)H-Index: 6
Last. Hitoshi ShimanoH-Index: 88
view all 27 authors...
: Dysfunctional hepatic lipid metabolism is a cause of non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disorder worldwide, and is closely associated with insulin resistance and type 2 diabetes (T2D). ELOVL fatty acid elongase 6 (Elovl6) is responsible for converting C16 saturated and monounsaturated fatty acids (FAs) into C18 species. We have previously shown that Elovl6 contributes to obesity-induced insulin resistance by modifying hepatic C16/C18-related FA composition...
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#1Rahul Sharma (University of Tsukuba)H-Index: 3
#2Takashi Matsuzaka (University of Tsukuba)H-Index: 41
Last. Hitoshi ShimanoH-Index: 88
view all 23 authors...
Brown adipose tissue (BAT) is an attractive therapeutic target for treating obesity and metabolic diseases. Octacosanol is the main component of policosanol, a mixture of very long chain aliphatic alcohols obtained from plants. The current study aimed to investigate the effect of octacosanol and policosanol on high-fat diet (HFD)-induced obesity. Mice were fed on chow, or HFD, with or without octacosanol or policosanol treatment for four weeks. HFD-fed mice showed significantly higher body weigh...
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#1Yuki Murayama (University of Tsukuba)H-Index: 6
#2Naoya Yahagi (University of Tsukuba)H-Index: 64
Last. Hitoshi Shimano (University of Tsukuba)H-Index: 88
view all 26 authors...
: Glucocorticoids have various medical uses but are accompanied by side effects. The glucocorticoid receptor (GR) has been reported to regulate the clock genes, but the underlying mechanisms are incompletely understood. In this study, we focused on the suppressive effect of the GR on the expression of Rev-erbα (Nr1d1), an important component of the clock regulatory circuits. Here we show that the GR suppresses Rev-erbα expression via the formation of a complex with CLOCK and BMAL1, which binds t...
Source
#1Shigeru YatohH-Index: 22
Last. Ommega InternationalsH-Index: 2
view all 7 authors...
Source
#1Shoko Furukawa (University of Tsukuba)H-Index: 3
#2Hiroaki Suzuki (University of Tsukuba)H-Index: 18
Last. Hitoshi Shimano (University of Tsukuba)H-Index: 88
view all 10 authors...
Abstract Background and aims Oxidized low-density lipoprotein (oxLDL) causes the development of atherosclerosis and kidney injury. Although circulating oxLDL levels were reportedly increased in type 2 diabetic patients with macroalbuminuria, it remains unclear whether albuminuria or the reduced glomerular filtration rate (GFR) is independently associated with the circulating oxLDL level. This study aimed to elucidate the association between the stage of diabetic nephropathy and serum malondialde...
Source
#1Hiroshi Ohno (University of Tsukuba)H-Index: 5
#2Takashi Matsuzaka (University of Tsukuba)H-Index: 41
Last. Hitoshi ShimanoH-Index: 88
view all 20 authors...
: Sterol regulatory element-binding protein (SREBP)-1a is a key transcription factor that activates the expression of genes involved in the synthesis of fatty acids, triglycerides (TGs), and cholesterol. Transgenic mice that overexpress the nuclear form of SREBP-1a under the control of the phosphoenolpyruvate carboxykinase promoter (Tg-1a) were previously shown to display a lipodystrophic phenotype characterized by enlarged and fatty livers, diminished peripheral white adipose tissue (WAT), and ...
Source
#1Erika Matsumura-Matsuda (University of Tsukuba)
#2Motohiro Sekiya (University of Tsukuba)H-Index: 29
Last. Hitoshi Shimano (University of Tsukuba)H-Index: 88
view all 14 authors...
We herein report a case of pheochromocytoma occurring in the course of Parkinson's disease. The coexistence of these two disease is extremely rare, with only four cases hitherto reported across the public databases. It is also noteworthy that biochemical tests, which are critical for the diagnosis of pheochromocytoma, are severely confounded by dopaminergic medications for Parkinson's disease, highlighting the importance of image-based modalities in this setting. We further attempted to gain ins...
Source
#1Xianying Piao (University of Tsukuba)H-Index: 3
#2Naoya Yahagi (University of Tsukuba)H-Index: 64
Last. Hitoshi Shimano (University of Tsukuba)H-Index: 88
view all 22 authors...
: The SNP rs7903146 at the transcription factor 7-like 2 (TCF7L2) locus is established as the strongest known genetic marker for type 2 diabetes via genome-wide association studies. However, the functional SNPs regulating TCF7L2 expression remain unclear. Here, we show that the SNP rs7074440 is a candidate functional SNP highly linked with rs7903146. A reporter plasmid with rs7074440 normal allele sequence exhibited 15-fold higher luciferase activity compared with risk allele sequence in hepatoc...
Source
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