William Greenhalf
University of Liverpool
CancerInternal medicineEndocrinologyPathologyOncologyImmunologyPancreatitisHereditary pancreatitisPancreatic diseasePancreasPancreatic cancerGemcitabineAdenocarcinomaPancreatic ductal adenocarcinomaCancer researchGeneticsDiabetes mellitusMedicineBiologyGastroenterology
Publications 259
Summary null Background null Microbiological characterisation of co-infections and secondary infections in patients with COVID-19 is lacking, and antimicrobial use is high. We aimed to describe microbiologically confirmed co-infections and secondary infections, and antimicrobial use, in patients admitted to hospital with COVID-19. null Methods null The International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) WHO Clinical Characterisation Protocol UK (CCP-UK) study is an...
1 CitationsSource
#1Annemarie B Docherty (Edin.: University of Edinburgh)H-Index: 19
#2Rachel H Mulholland (Edin.: University of Edinburgh)H-Index: 3
Last. Peter YoungH-Index: 2
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Summary Background Mortality rates in hospitalised patients with COVID-19 in the UK appeared to decline during the first wave of the pandemic. We aimed to quantify potential drivers of this change and identify groups of patients who remain at high risk of dying in hospital. Methods In this multicentre prospective observational cohort study, the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK recruited a prospective cohort of pat...
1 CitationsSource
#1Thomas M Drake (Edin.: University of Edinburgh)H-Index: 16
#2Cameron J Fairfield (Edin.: University of Edinburgh)H-Index: 8
Last. Peter YoungH-Index: 2
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Summary Background Early in the pandemic it was suggested that pre-existing use of non-steroidal anti-inflammatory drugs (NSAIDs) could lead to increased disease severity in patients with COVID-19. NSAIDs are an important analgesic, particularly in those with rheumatological disease, and are widely available to the general public without prescription. Evidence from community studies, administrative data, and small studies of hospitalised patients suggest NSAIDs are not associated with poorer COV...
1 CitationsSource
#1Saye Khoo (University of Liverpool)H-Index: 69
#2Richard FitzgeraldH-Index: 9
Last. Gareth GriffithsH-Index: 30
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BackgroundAGILE is a phase Ib/IIa platform for rapidly evaluating COVID-19 treatments. In this trial (NCT04746183) we evaluated the safety and optimal dose of molnupiravir in participants with early symptomatic infection. MethodsWe undertook a dose-escalating, open-label, randomised-controlled (standard-of-care) Bayesian adaptive phase I trial at the Royal Liverpool and Broadgreen Clinical Research Facility. Participants (adult outpatients with PCR-confirmed SARS-CoV-2 infection within 5 days of...
#1Milton Ashworth (University of Liverpool)H-Index: 1
#2Benjamin Small (University of Liverpool)
Last. Eithne Costello (University of Liverpool)H-Index: 51
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Accurate blood-borne biomarkers are sought for diagnosis, prognosis and treatment stratification. Consistent handling of blood is essential for meaningful data interpretation, however, delays during processing are occasionally unavoidable. We investigated the effects of immediately placing blood samples on ice versus room temperature for 1 h (reference protocol), and holding samples on ice versus room temperature during a 3 h delay to processing. Using Luminex multi-plex assays to assess cytokin...
#1Wega Setiabudi (University of Liverpool)
#1Setiabudi W (University of Liverpool)
Last. Neil French (University of Liverpool)H-Index: 56
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Introduction The emergence and rapid spread of COVID-19 have caused widespread and catastrophic public health and economic impact, requiring governments to restrict societal activity to reduce the spread of the disease. The role of household transmission in the population spread of SARS-CoV-2, and of host immunity in limiting transmission, is poorly understood. This paper describes a protocol for a prospective observational study of a cohort of households in Liverpool City Region, UK, which addr...
BACKGROUND: Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% of the phenotypic variance. METHODS: We complemented a new conventional PC GWAS (1D) with genome spatial autocorrelation analysis (2D) permitting to prioritize low frequency variants not detected by GWAS. These were further expanded via Hi-C map (3D) interactions to gain additio...
#1Silvana Debernardi (QMUL: Queen Mary University of London)H-Index: 17
#2Harrison O’Brien (QMUL: Queen Mary University of London)H-Index: 1
Last. Tatjana Crnogorac-Jurcevic (QMUL: Queen Mary University of London)H-Index: 34
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Publisher Copyright: © 2020 Debernardi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
1 CitationsSource
#1Lucy OldfieldH-Index: 4
#2Rohith RaoH-Index: 1
Last. Eithne CostelloH-Index: 51
view all 6 authors...