Maria Cristina Bonferoni
University of Pavia
BiophysicsBiomedical engineeringNuclear chemistryChemistryMaterials scienceBuccal administrationRheologyIn vivoPlatelet lysateChitosanDrug deliveryMucoadhesionDrugWound healingChemical engineeringChromatographyPolymerMedicineDosage formPharmacology
247Publications
43H-index
4,636Citations
Publications 175
Newest
#1Sara PerteghellaH-Index: 17
#2Giovanna RassuH-Index: 23
Last. Maria Luisa TorreH-Index: 26
view all 9 authors...
The nose-to-brain delivery route is used to bypass the blood–brain barrier and deliver drugs directly into the brain. Over the years, significant signs of progress have been made in developing nano-drug delivery systems to address the very low drug transfer levels seen with conventional formulations (e.g., nasal solutions). In this paper, sericin nanoparticles were prepared using crocetin as a new bioactive natural cross-linker (NPc) and compared to sericin nanoparticles prepared with glutaralde...
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#1Barbara ViganiH-Index: 14
#2Caterina ValentinoH-Index: 1
Last. Franca FerrariH-Index: 38
view all 11 authors...
Glioblastoma multiforme (GBM) is one of the most prevalent and aggressive brain tumors for which there is currently no cure. A novel composite nanosystem (CN), consisting of chitosan-coated Solid Lipid Nanoparticles (c-SLN) embedded in O-carboxymethyl chitosan (O-CMCS)-containing nanofibers (NFs), was proposed as a potential tool for the local delivery of lipophilic anti-proliferative drugs. Coacervation was selected as a solvent-free method for the preparation of stearic acid (SA) and behenic a...
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#1Stefano DugheriH-Index: 9
#2Daniela Massi (UniFI: University of Florence)H-Index: 48
Last. Giulio Arcangeli (UniFI: University of Florence)H-Index: 17
view all 8 authors...
Abstract Air monitoring is the quantitative-qualitative assessment of the extent of pollutants. It is performed to ensure compliance with legislation and to evaluate control measures and mitigation solutions. There are numerous approaches to measure airborne formaldehyde (FA), ranging from passive sampling techniques to remote sensing devices. Research of sampling procedures and analytical methods was performed in a scientific database and on the web to offer a scenario of the devices and techni...
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#1Barbara ViganiH-Index: 14
#2Caterina ValentinoH-Index: 1
Last. Franca FerrariH-Index: 38
view all 11 authors...
Injuries to the nervous system affect more than one billion people worldwide, and dramatically impact on the patient’s quality of life. The present work aimed to design and develop a gellan gum (GG)-based composite system for the local delivery of the neuroprotective sigma-1 receptor agonist, 1-[3-(1,1′-biphen)-4-yl] butylpiperidine (RC-33), as a potential tool for the treatment of tissue nervous injuries. The system, consisting of cross-linked electrospun nanofibers embedded in a RC-33-loaded f...
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#1Mária Budai-Szűcs (University of Szeged)H-Index: 12
#2Marco Ruggeri (UNIPV: University of Pavia)H-Index: 5
Last. Franca Ferrari (UNIPV: University of Pavia)H-Index: 38
view all 12 authors...
Periodontitis is a set of inflammatory conditions affecting the tissues surrounding the teeth predominantly sustained by bacterial infections. The aim of the work was the design and the development of scaffolds based on biopolymers to be inserted in the periodontal pocket to restore tissue integrity and to treat bacterial infections. Nanofibrous scaffolds were prepared by means of electrospinning. Gelatin was considered as base component and was associated to low and high molecular weight chitos...
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#1Eleonora Bianchi (UNIPV: University of Pavia)H-Index: 1
#2Marco Ruggeri (UNIPV: University of Pavia)H-Index: 5
Last. Franca Ferrari (UNIPV: University of Pavia)H-Index: 38
view all 8 authors...
The tendon is a highly aligned connective tissue that transmits force from muscle to bone. Each year, more than 32 million tendon injuries have been reported, in fact, tendinopathies represent at least 50% of all sports injuries, and their incidence rates have increased in recent decades due to the aging population. Current clinical grafts used in tendon treatment are subject to several restrictions and there is a significant demand for alternative engineered tissue. For this reason, innovative ...
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#1Maria Cristina Bonferoni (UNIPV: University of Pavia)H-Index: 43
#2Giovanna Rassu (University of Sassari)H-Index: 23
Last. Paolo Giunchedi (University of Sassari)H-Index: 37
view all 6 authors...
Oxidative stress has a key role in the pathogenesis of neurodegenerative disorders such as Alzheimer's, Parkinson's, and Huntington's diseases and can be an important cause of the damages in cerebral ischemia. Oxidative stress arises from high levels of reactive oxygen species (ROS). Consequently, on this rational base, antioxidants (many of natural origin) are proposed as potential drugs to prevent ROS noxious actions because they can protect the target tissues from the oxidative stress. Howeve...
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#1Dalila Miele (UNIPV: University of Pavia)H-Index: 5
#2Laura Catenacci (UNIPV: University of Pavia)H-Index: 18
Last. Maria Cristina Bonferoni (UNIPV: University of Pavia)H-Index: 43
view all 11 authors...
Collagen, thanks to its biocompatibility, biodegradability and weak antigenicity, is widely used in dressings and scaffolds, also as electrospun fibers. Its mechanical stability can be improved by adding polycaprolactone (PCL), a synthetic and biodegradable aliphatic polyester. While previously collagen/PCL combinations were electrospun in solvents such as hexafluoroisopropanol (HFIP) or trifluoroethanol (TFE), more recently literature describes collagen/PCL nanofibers obtained in acidic aqueous...
1 CitationsSource
#1Barbara ViganiH-Index: 14
#2Silvia RossiH-Index: 36
Last. Franca FerrariH-Index: 38
view all 6 authors...
In situ gelling drug delivery systems have gained enormous attention over the last decade. They are in a sol-state before administration, and they are capable of forming gels in response to different endogenous stimuli, such as temperature increase, pH change and the presence of ions. Such systems can be administered through different routes, to achieve local or systemic drug delivery and can also be successfully used as vehicles for drug-loaded nano- and microparticles. Natural, synthetic and/o...
2 CitationsSource
#1Marco RuggeriH-Index: 5
#2Eleonora BianchiH-Index: 1
Last. Franca FerrariH-Index: 38
view all 8 authors...
Chronic wounds, such as pressure ulcers, diabetic ulcers, venous ulcers and arterial insufficiency ulcers, are lesions that fail to proceed through the normal healing process within a period of 12 weeks. The treatment of skin chronic wounds still represents a great challenge. Wound medical devices (MDs) range from conventional and advanced dressings, up to skin grafts, but none of these are generally recognized as a gold standard. Based on recent developments, this paper reviews nanotechnology-b...
2 CitationsSource