Ya. D. Shanskii
Transforming growth factorCell migrationCellAlkaline phosphataseAndrologyAdipose tissueFetusChemistryMesenchymal stem cellIn vitroImmunologyIn vivoGranulation tissuePlatelet lysateLactate dehydrogenaseStem cellCell culturePlateletCell biology
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: Platelet lysate prepared from donor platelet concentrate and pooled according to a developed technique stimulates migration of multipotent mesenchymal stromal cells of the human adipose tissue and promotes healing of the monolayer defect in cultures of human fibroblasts and multipotent mesenchymal stromal cells in vitro in concentrations close those of fetal calf serum (5-10%). Lysate of platelets from platelet-rich rat blood plasma stimulated healing of the skin defect by promoting epithelial...
6 CitationsSource
#1Ya. D. ShanskiiH-Index: 2
#2N. S. Sergeeva (RSMU: Russian National Research Medical University)H-Index: 6
Last. Chissov Vi (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 3
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We compared the composition and biological activity of fetal calf serum and platelet lysate from donor platelet concentrate. In platelet lysate, the concentrations of alkaline phosphatase, lactate dehydrogenase, creatinine, and mineral metabolism parameters were lower, while parameters of lipid and protein metabolism were higher than in fetal calf serum. The concentrations of growth factors (platelet-derived (AA, AB, BB), vascular endothelial, insulin-like, and transforming growth factor β) in p...
23 CitationsSource