Giovanni Mario Pes
University of Sassari
Internal medicineEndocrinologyCase-control studyDemographyRetrospective cohort studyAlleleChemistryImmunologyGeographyHelicobacter pyloriLongevityDiseasePopulationCancer researchGeneticsDiabetes mellitusMedicineCohortBiologyGastroenterology
151Publications
29H-index
2,547Citations
Publications 145
Newest
#1Michel Poulain (UCL: Université catholique de Louvain)H-Index: 17
#2Dany ChambreH-Index: 4
Last. Giovanni Mario Pes (University of Sassari)H-Index: 29
view all 3 authors...
Background null Although it is known that mortality due to COVID-19 increases progressively with age, the probability of dying from this serious infection among the oldest-old population is little known, and controversial data are found in literature. null Methods null We examine the mortality by year and month of birth of Belgians who had turned 100 during the current COVID-19 pandemic and whose birth fell on the years around the end the First World War and the outbreak of the H1N1 "Spanish flu...
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#1Maria Pina Dore (University of Sassari)H-Index: 32
#2Guido Parodi (University of Sassari)H-Index: 44
Last. Giovanni Mario Pes (University of Sassari)H-Index: 29
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The role of water hardness on human health is still debated, ranging from beneficial to harmful. Before the rise of drinking bottled water, it was a common habit to obtain supplies of drinking water directly from spring-fed public fountains. According to the geographic location, spring waters are characterized by a variable content of mineral components. In this ecological study, for the first time in Sardinia, Italy, the spatial association between spring water quality/composition and standardi...
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#1Michel Poulain (UCL: Université catholique de Louvain)H-Index: 17
#2Anne Herm (TU: Tallinn University)H-Index: 7
Last. Claudio FranceschiH-Index: 131
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Human longevity may be found in single individuals as well as in the population as a whole ("population longevity"). Longevity Blue Zones (LBZs), which are areas with an unusually high number of oldest old, have been identified in Sardinia and the Greek island of Ikaria. We compared the lifestyle, health status and some genetic markers of the LBZ populations with those of reference populations from Italy and Greece; the data were extracted from the GEHA database. In the LBZs, the proportion of i...
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#7Jie Zhang (PKU: Peking University)H-Index: 9
Background & aims Mothers against decapentaplegic homolog 7 (SMAD7) is an antagonist of the transforming growth factor β (TGF-β) signaling. In the present investigation, we sought to determine the relevance of SMAD7 in liver carcinogenesis using in vitro and in vivo approaches. Approach & results We found that SMAD7 is upregulated in a subset of human hepatocellular carcinoma (HCC) samples with poor prognosis. Gene set enrichment analysis (GSEA) revealed that SMAD7 expression correlates with act...
5 CitationsSource
#1Giovanni Mario Pes (University of Sassari)H-Index: 29
#2Maria Pina Dore (University of Sassari)H-Index: 32
Source
#1Maria Pina Dore (University of Sassari)H-Index: 32
#2Giovanni Mario Pes (University of Sassari)H-Index: 29
Last. Giuseppe Realdi (UNIPD: University of Padua)H-Index: 33
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Abstract The effect of hyper-mineral waters on human health has long been debated. This pilot study evaluated the influence of San Martino® water (Sardinia, Italy), on clinical and biological parameters, following the treatment of 10 hospitalized patients. Crenotherapy consisted of 1–2 L of the water daily for 10 days. A complete blood count, serum electrolytes, liver and kidney function tests, fasting lipid profile and plasma glucose, and abdominal ultrasound imaging were assessed before and at...
1 CitationsSource
#1Maria Pina Dore (University of Sassari)H-Index: 32
#2Michele PortogheseH-Index: 2
Last. Giovanni Mario Pes (University of Sassari)H-Index: 29
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AIM Recent studies suggest that glucose-6-phosphate dehydrogenase (G6PD) deficiency, a genetically inherited condition causing hemolytic anemia, may be a risk factor for cardiovascular disease (CVD). We aimed to perform a retrospective case-control study in Sardinia taking advantage from clinical records of patients undergoing upper digestive endoscopy and screened for H. pylori infection. METHODS A total of 9,604 patients with a known G6PD status and a complete clinical history, encompassing CV...
2 CitationsSource
#1Xinhua Song (UCSF: University of California, San Francisco)H-Index: 13
#2Hongwei Xu (UCSF: University of California, San Francisco)H-Index: 1
Last. Diego F. Calvisi (University of Regensburg)H-Index: 18
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BACKGROUND & AIMS Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase upregulated in many tumor types and a promising target for cancer therapy. Here, we elucidated the functional role of FAK in intrahepatic cholangiocarcinoma (iCCA) development and progression. METHODS Expression levels and activation status of FAK were determined in human iCCA samples. The functional contribution of FAK to Akt/YAP murine iCCA initiation and progression was investigated using conditional Fak KO mice a...
1 CitationsSource
Helicobacter pylori infection remains one of the most prevalent infections worldwide, especially in low-resource countries, and the major risk factor for peptic ulcer and gastric cancer. The “test-and-treat” strategy is recommended by several guidelines and consensus. The choice of testing method is based on patient age, presence of alarm signs and/or symptoms, use of non-steroidal anti-inflammatory drugs, as well as local availability, test reliability, and cost. Culture is the gold standard to...
1 CitationsSource
#1Maria Pina Dore (University of Sassari)H-Index: 32
#2Guido Parodi (University of Sassari)H-Index: 44
Last. Giovanni Mario Pes (University of Sassari)H-Index: 29
view all 4 authors...
Cardiovascular disorders (CVD) are highly prevalent and the leading cause of death worldwide. Atherosclerosis is responsible for most cases of CVD. The plaque formation and subsequent thrombosis in atherosclerosis constitute an ongoing process that is influenced by numerous risk factors such as hypertension, diabetes, dyslipidemia, obesity, smoking, inflammation, and sedentary lifestyle. Among the various risk and protective factors, the role of glucose-6-phosphate dehydrogenase (G6PD) deficienc...
1 CitationsSource