Denis Cominetti
University of Milan
CancerInternal medicineOncologymicroRNACellChemistryApoptosisImmunologyIn vivoTumor microenvironmentHistone deacetylase inhibitorChemotherapyHeparanaseBevacizumabCisplatinSunitinibProstate cancerDoxorubicinCancer researchCell growthMedicineCell cultureBiologyPharmacology
27Publications
14H-index
464Citations
Publications 27
Newest
#1Federica RotundoH-Index: 2
#2Denis CominettiH-Index: 14
Last. Paolo GandelliniH-Index: 25
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The development of novel therapies or the improvement of currently used approaches to treat prostate cancer (PCa), the most frequently diagnosed male tumor in developed countries, is an urgent need. In this regard, the functional characterization of microRNAs, molecules shown to regulate a number of cancer-related pathways, is instrumental to their possible clinical exploitation. Here, we demonstrate the tumor-suppressive role of the so far uncharacterized miR-1272, which we found to be signific...
1 CitationsSource
#1Silvia StacchiottiH-Index: 61
#2Valentina ZucoH-Index: 25
Last. Nadia ZaffaroniH-Index: 66
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Epithelioid sarcoma (ES) is a rare mesenchymal malignancy marked by SMARCB1/INI1 deficiency. Retrospective clinical data report on the activity of anthracycline- and gemcitabine-based regimens. EZH2 inhibitors are currently being tested in clinical trials. Since comparisons of these agents are unlikely to be prospectively evaluated in the clinics, we took advantage of an INI1-deficient proximal-type ES patient-derived xenograft (PDX ES-1) to comparatively assess its preclinical antitumor activit...
6 CitationsSource
#1Paolo GandelliniH-Index: 25
#2Rihan El BezawyH-Index: 3
Last. Nadia ZaffaroniH-Index: 66
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Radiotherapy is a standard treatment for organ-confined prostate cancer (PCa). Although treatment technical optimization has greatly improved local tumor control, a significant percentage of patients still undergo recurrence. The onset of radioresistance is a complex phenomenon involving several genetic and epigenetic abnormalities, including the deregulation of microRNAs (miRNAs), endogenous small noncoding RNA molecules that negatively regulate gene expression. In this study, we investigated t...
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#1Giuliana CassinelliH-Index: 30
#2Laura Dal BoH-Index: 13
Last. Cinzia LanziH-Index: 30
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Abstract Synovial sarcoma (SS) is an aggressive tumor with propensity for lung metastases which significantly impact patients' prognosis. New therapeutic approaches are needed to improve treatment outcome. Targeting the heparanase/heparan sulfate proteoglycan system by heparin derivatives which act as heparanase inhibitors/heparan sulfate mimetics is emerging as a therapeutic approach that can sensitize the tumor response to chemotherapy. We investigated the therapeutic potential of a supersulfa...
14 CitationsSource
#1Anna RossiniH-Index: 11
#2Franco ZuninoH-Index: 75
Last. Massimo Di NicolaH-Index: 30
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10 CitationsSource
#1Rihan El BezawyH-Index: 3
#2Denis CominettiH-Index: 14
Last. Paolo GandelliniH-Index: 25
view all 12 authors...
Abstract Radiotherapy is one of the main treatment choices for non-metastatic prostate cancer (PCa), although development of radioresistance limits its effectiveness. Mounting evidence supports the ability of microRNAs to interfere with different radioresistance-associated pathways, suggesting their potential as radiosensitizers. Here, we demonstrate that reconstitution of miR-875-5p, whose expression is down-regulated in PCa clinical samples and directly correlates with that of E-cadherin, was ...
57 CitationsSource
#1Silvia StacchiottiH-Index: 61
#2Maurizio SaponaraH-Index: 1
Last. Nadia ZaffaroniH-Index: 66
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Abstract Background Preclinical models that mimic pathological and molecular features of solitary fibrous tumour (SFT) represent an important tool to select effective regimes and novel compounds to be tested in the clinic. This study was aimed at developing two preclinical models of SFT, assessing their predictive value in the clinic and selecting potential novel effective treatments. Material and methods Two dedifferentiated-SFT (D-SFT) models obtained from patients' biopsies were grown in immu...
13 CitationsSource
#1Virginia Spanò (University of Palermo)H-Index: 18
#2Marzia PennatiH-Index: 28
Last. Paola Barraja (University of Palermo)H-Index: 33
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Abstract A series of [1,2]Oxazolo [5,4- e ]isoindoles has been synthesized through a versatile and high yielding sequence. All the new structures showed in the 1 HNMR spectra, the typical signal in the 8.34–8.47 ppm attributable to the H-3 of the [1,2]oxazole moiety. Among all derivatives, methoxy benzyl substituents at positions 3 and 4 or/and 5 were very effective in reducing the growth of different tumor cell lines, including diffuse malignant peritoneal mesothelioma (DMPM), an uncommon and r...
15 CitationsSource
#1Virginia Spanò (University of Palermo)H-Index: 18
#2Marzia PennatiH-Index: 28
Last. Nadia ZaffaroniH-Index: 66
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A series of 22 derivatives of the [1,2]oxazolo[5,4-e]isoindole system were synthesized through an efficient and versatile procedure that involves the annelation of the [1,2]oxazole moiety to the isoindole ring, producing derivatives with a wide substitution pattern. The structure–activity relationship indicates that the N-4-methoxybenzyl group appears crucial for potent activity. In addition, the presence of a 6-phenyl moiety is important and the best activity is reached with a 3,4,5-trimethoxy ...
24 CitationsSource
#1Massimo Di NicolaH-Index: 30
#2Franco ZuninoH-Index: 75
Last. Nadia ZaffaroniH-Index: 66
view all 12 authors...
Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA Background: The standard chemotherapy treatment for Non-Hodgkin lymphoma (NHL) consists in the combination of cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP). Because of the relevant treatment-related toxicity and the minor therapeutic effectiveness of CHOP therapy variants, the development of novel therapeutic approaches represents an urgent clinical need. Despite treatment with the anti-CD20 monocl...
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