Paolo Gandellini
University of Milan
GeneCancerInternal medicineOncologymicroRNAGene expressionApoptosisImmunologyTumor microenvironmentDU145MetastasisDiseaseProstate cancerCancer researchBioinformaticsCell growthMedicineBiologyTelomeraseCell biologyCancer cell
65Publications
25H-index
2,129Citations
Publications 64
Newest
#1Paolo GandelliniH-Index: 25
#2Marco FoliniH-Index: 37
Last. Nadia ZaffaroniH-Index: 66
view all 3 authors...
Eradication of advanced prostate cancer still represents an unsolved clinical problem, making the development of alternative treatment approaches highly desirable. Understanding the molecular alterations that distinguish the non-progressive from progressive disease will allow the identification of novel biomarkers for improved staging and prognostication, and will also provide mechanistic information to facilitate treatment selection and design of novel therapeutic approaches. MicroRNAs (miRNAs)...
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#1Marzia PennatiH-Index: 28
Last. Nadia ZaffaroniH-Index: 66
view all 7 authors...
Source
#1Paolo GandelliniH-Index: 25
#2Marco FoliniH-Index: 37
Last. Nadia ZaffaroniH-Index: 66
view all 3 authors...
: MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression. Recent findings indicate that miRNAs are dysregulated in human tumors, suggesting a potential role for these molecules in the pathogenesis of cancer. Thus far, only a limited number of studies have investigated miRNA expression in prostate cancer. Results from these studies indicate that miRNA expression profiles may distinguish carcinoma from non-neoplastic specimens and further classify tumors according to...
27 Citations
#1Marco FoliniH-Index: 37
#2Paolo GandelliniH-Index: 25
Last. Nadia ZaffaroniH-Index: 66
view all 13 authors...
Background Aberrant expression of microRNAs, small non-coding RNA molecules that post-transcriptionally repress gene expression, seems to be causatively linked to the pathogenesis of cancer. In this context, miR-21 was found to be overexpressed in different human cancers (e.g. glioblastoma, breast cancer). In addition, it is thought to be endowed with oncogenic properties due to its ability to negatively modulate the expression of tumor-suppressor genes (e.g. PTEN) and to cause the reversion of ...
199 CitationsSource
#1Paolo GandelliniH-Index: 25
#2Marco FoliniH-Index: 37
Last. Nadia ZaffaroniH-Index: 66
view all 3 authors...
Eradication of advanced prostate cancer still represents an unsolved clinical problem, making the development of alternative treatment approaches highly desirable. Understanding the molecular alterations that distinguish non-progressive from progressive disease would provide mechanistic information for the identification of new therapeutic targets. Recent findings indicate that human tumors have deregulated expression of microRNAs, which have thus been proposed as novel oncogenes or tumor suppre...
79 CitationsSource
Since telomere integrity is required to guarantee the unlimited replicative potential of cancer cells, telomerase, the enzyme responsible for telomere length maintenance in most human tumors, and lately also telomeres themselves have become extremely attractive targets for new anticancer interventions. At the current status of knowledge, it is still not possible to define the best therapeutic target between telomerase and telomeres. It is noteworthy that interfering with telomeres, through direc...
54 CitationsSource
#1Paolo GandelliniH-Index: 25
#2Marco FoliniH-Index: 37
Last. Nadia ZaffaroniH-Index: 66
view all 13 authors...
Limited information is available concerning the expression and role of microRNAs in prostate cancer. In this study, we investigated the involvement of miR-205 in prostate carcinogenesis. Significantly lower miR-205 expression levels were found in cancer than in normal prostate cell lines as well as in tumor compared with matched normal prostate tissues, with a particularly pronounced reduction in carcinomas from patients with local-regionally disseminated disease. Restoring the expression of miR...
381 CitationsSource
#1Alessia LopergoloH-Index: 13
#2Marzia PennatiH-Index: 28
Last. Nadia ZaffaroniH-Index: 66
view all 8 authors...
We analysed the effects of small interfering RNA (siRNA)-mediated silencing of Apollon, a member of the inhibitors of apoptosis protein family, on the proliferative potential and ability of human breast cancer cell lines to undergo apoptosis. In wild-type p53 ZR75.1 cells, Apollon knockdown resulted in a marked, time-dependent decline of cell growth and an increased rate of apoptosis, which was associated with p53 stabilisation and activation of the mitochondrial-dependent apoptotic pathway. Pre...
50 CitationsSource
#1Marzia PennatiH-Index: 28
Last. Nadia ZaffaroniH-Index: 66
view all 6 authors...
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#1Marco FoliniH-Index: 37
#2R. BandieraH-Index: 1
Last. Nadia ZaffaroniH-Index: 66
view all 11 authors...
. Objectives: Peptide nucleic acids (PNAs) are DNA mimics that have been demonstrated to be efficient antisense/antigene tools in cell-free systems. However, their potential as in vivo regulators of gene expression has been hampered by their poor uptake by living cells, and strategies need to be developed for their intracellular delivery. This study has aimed to demonstrate the possibility (i) of efficiently delivering a PNA, which targets mRNA of the catalytic component of human telomerase reve...
25 CitationsSource