Paolo Gandellini
University of Milan
GeneCancerInternal medicineOncologymicroRNAGene expressionApoptosisImmunologyTumor microenvironmentDU145MetastasisDiseaseProstate cancerCancer researchBioinformaticsCell growthMedicineBiologyTelomeraseCell biologyCancer cell
Publications 64
Background Understanding the molecular/cellular underpinnings of diffuse malignant peritoneal mesothelioma (DMPM), a fatal malignancy with limited therapeutic options, is of utmost importance for the fruitful management of the disease. In this context, we previously found that telomerase activity (TA), which accounts for the limitless proliferative potential of cancer cells, is prognostic for disease relapse and cancer-related death in DMPM patients. Consequently, the identification of factors i...
13 CitationsSource
#1Rihan El BezawyH-Index: 3
Last. Nadia ZaffaroniH-Index: 66
view all 7 authors...
#1Paolo GandelliniH-Index: 25
#2Valentina DoldiH-Index: 8
Last. Nadia ZaffaroniH-Index: 66
view all 3 authors...
Abstract microRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. Increasing evidence emerging from human tumor preclinical models clearly indicates that specific miRNAs, collectively termed “metastamirs,” play a functional role in different steps of the metastatic cascade, by exerting either pro- or anti-metastatic functions, and behave as signaling mediators to enable tumor cell to colonize a specific organ. miRNAs also actively p...
29 CitationsSource
#1Rihan El BezawyH-Index: 3
#2Denis CominettiH-Index: 14
Last. Paolo GandelliniH-Index: 25
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Abstract Radiotherapy is one of the main treatment choices for non-metastatic prostate cancer (PCa), although development of radioresistance limits its effectiveness. Mounting evidence supports the ability of microRNAs to interfere with different radioresistance-associated pathways, suggesting their potential as radiosensitizers. Here, we demonstrate that reconstitution of miR-875-5p, whose expression is down-regulated in PCa clinical samples and directly correlates with that of E-cadherin, was ...
57 CitationsSource
Background The value of microRNAs (miRNAs) as novel targets for cancer therapy is now widely recognized. However, no information is currently available on the expression/functional role of miRNAs in diffuse malignant peritoneal mesothelioma (DMPM), a rapidly lethal disease, poorly responsive to conventional treatments, for which the development of new therapeutic strategies is urgently needed. Here, we evaluated the expression and biological effects of miR-34a—one of the most widely deregulated ...
25 CitationsSource
#1Noemi ArrighettiH-Index: 11
#2Giacomo CossaH-Index: 15
Last. Laura GattiH-Index: 27
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The occurrence of drug resistance limits the efficacy of platinum compounds in the cure of ovarian carcinoma. Since microRNAs (miRNAs) may contribute to this phenomenon by regulating different aspects of tumor cell response, the aim of this study was to exploit the analysis of expression of miRNAs in platinum sensitive/resistant cells in an attempt to identify potential regulators of drug response. MiR-483-3p, which may participate in apoptosis and cell proliferation regulation, was found up-reg...
16 CitationsSource
Metastatic prostate cancer is a lethal disease that remains incurable despite the recent approval of new drugs, thus making the development of alternative treatment approaches urgently needed. A more precise understanding of the molecular mechanisms underlying prostate cancer dissemination could lead to the identification of novel therapeutic targets for the design of efficient anti-metastatic strategies. MicroRNA (miRNAs) are endogenous, small non-coding RNA molecules acting as key regulators o...
17 CitationsSource
#1Marzia PennatiH-Index: 28
#2Marco FoliniH-Index: 37
Last. Nadia ZaffaroniH-Index: 66
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Despite considerable advances in early diagnosis, prostate cancer (PCa) remains the second leading cause of cancer-related deaths in men in western countries. In fact, although efficient therapies exist for early-stage disease, the treatment of advanced PCa remains unsuccessful mainly due to its poor responsiveness to anti-cancer agents. This evidence underlines the urgent need for the development of novel and more effective therapeutic approaches. In this context, the documented dysregulation o...
5 CitationsSource
#1Nicola FendericoH-Index: 8
#2Denis CominettiH-Index: 14
Last. Nadia ZaffaroniH-Index: 66
view all 8 authors...
Acquisition of mesenchymal features by carcinoma cells through the epithelial-mesenchymal transition (EMT) is responsible for the initiation and sustainment of the metastatic cascade, as well as the establishment of a chemo- and radio-resistant phenotype. In prostate cancer (PCa), metastatic disease remains incurable despite the approval of several new drugs for clinical use in recent years. In addition, emergence of resistance to radiotherapy, which is one of the mostly used therapeutic options...