Jiro Suzuki
Okayama University
Bone morphogenetic protein 7Internal medicineAutocrine signallingEndocrinologyReceptorBone morphogenetic protein 6ChemistryRenin–angiotensin systemACVR2BMineralocorticoidCushing's diseaseGranulosa cellAdenomaAdrenal cortexAldosteroneFollistatinProlactinForskolinPituitary adenomaDexamethasoneOvarian follicleAngiotensin IICortisol secretionBone morphogenetic proteinActivin type 2 receptorsMAPK/ERK pathwaySignal transductionMedicineBMPR2BiologyCell biologyProtein kinase A
38Publications
18H-index
833Citations
Publications 38
Newest
#1Jiro Suzuki (Okayama University)H-Index: 18
#2Fumio Otsuka (Okayama University)H-Index: 35
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 10 authors...
Enhanced expression of bone morphogenetic protein system in aldosterone-treated mouse kidneys
5 CitationsSource
#1Jiro Suzuki (Okayama University)H-Index: 18
#2Fumio Otsuka (Okayama University)H-Index: 35
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 10 authors...
Source
#1Naoko Tsukamoto (Okayama University)H-Index: 13
#2Fumio Otsuka (Okayama University)H-Index: 35
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 9 authors...
Involvement of the pituitary BMP system in the modulation of prolactin (PRL) secretion regulated by somatostatin analogs, including octreotide (OCT) and pasireotide (SOM230), and a dopamine agonist, bromocriptine (BRC), was examined in GH3 cells. GH3 cells are rat pituitary somato-lactotrope tumor cells that express somatostatin receptors (SSTRs) and BMP system molecules including BMP-4 and -6. Treatment with BMP-4 and -6 increased PRL and cAMP secretion by GH3 cells. The BMP-4 effects were neut...
13 CitationsSource
#1Eri Nakamura (Okayama University)H-Index: 13
#2Fumio Otsuka (Okayama University)H-Index: 35
Last. Hirofumi Makino (Okayama University)H-Index: 98
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To investigate the mechanism by which prolactin (PRL) regulates follicular steroidogenesis in the ovary, we examined the functional roles of PRL in steroidogenesis using rat oocyte/granulosa cell coculture and focusing on the bone morphogenetic protein (BMP) system. The expression of long and short forms of PRL receptor (PRLR) were detected in both oocytes and granulosa cells, and PRL effectively up-regulated PRLR expression in granulosa cells in the presence of FSH. PRL suppressed FSH-induced e...
26 CitationsSource
#1Tomoko Miyoshi (Okayama University)H-Index: 16
#2Fumio Otsuka (Okayama University)H-Index: 35
Last. Hirofumi Makino (Okayama University)H-Index: 98
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Abstract Bone morphogenetic proteins (BMPs) have been recognized as crucial molecules in regulating ovarian physiology, with different BMPs having differential actions in FSH-induced estradiol production. To identify the roles of oocyte factors that modulate steroidogenesis controlled by BMPs, we here investigated the effects of FGF-8 in rat granulosa/oocyte co-cultures. FGF-8 potently suppressed FSH-induced estradiol production, but did not affect cAMP-induced estradiol produced by rat granulos...
29 CitationsSource
#1Hiroyuki Otani (Okayama University)H-Index: 16
#2Fumio Otsuka (Okayama University)H-Index: 35
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 5 authors...
Aldosterone production occurs in the adrenal cortex, and is regulated primarily by angiotensin II (Ang II), potassium and adrenocorticotropin (ACTH). In the presence of the aldosterone stimulators, steroidogenesis is further governed by local autocrine and/or paracrine factors in the adrenal cortex. We reported the presence of functional bone morphogenetic protein (BMP) system in the adrenal cortex and also demonstrated that BMP-6 increases Ang II-induced aldosterone production, which could be i...
6 CitationsSource
#1Fumio OtsukaH-Index: 35
#2Ryutaro YamanakaH-Index: 9
Last. Hirofumi MakinoH-Index: 98
view all 9 authors...
#1Tomoko MiyoshiH-Index: 16
#2Fumio OtsukaH-Index: 35
Last. Hirofumi MakinoH-Index: 98
view all 6 authors...
#1Naoko Tsukamoto (Okayama University)H-Index: 13
#2Fumio Otsuka (Okayama University)H-Index: 35
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 12 authors...
The mechanism by which somatostatin analogs suppress ACTH production by corticotropinomas has yet to be fully elucidated. We here studied the effects of somatostatin analogs on ACTH secretion using mouse corticotrope AtT20 cells focusing on the biological activity of bone morphogenetic proteins (BMPs). BMP ligands, receptors and Smads, and somatostatin receptors (SSTRs)-2, -3, and -5 were expressed in AtT20 cells. BMP-2, -4, -6, and -7 decreased basal ACTH production with BMP-4 effects being the...
33 CitationsSource
#1Hiroyuki Otani (Okayama University)H-Index: 16
#2Fumio Otsuka (Okayama University)H-Index: 35
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 11 authors...
Recent studies have shown that bone morphogenetic proteins (BMPs) are important regulators in the pituitary–gonadal endocrine axis. We here investigated the effects of BMPs on GNRH production controlled by estrogen using murine GT1-7 hypothalamic neuron cells. GT1-7 cells expressed estrogen receptor a (ERa; ESR1 as listed in MGI Database), ERb (ESR2 as listed in MGI Database), BMP receptors, SMADs, and a binding protein follistatin. Treatment with BMP2 and BMP4 had no effect on Gnrh mRNA express...
19 CitationsSource