Sophia Hober
Royal Institute of Technology
AntigenProtein engineeringMolecular biologyHuman Protein AtlasAntibodyAffinity chromatographyChemistryPhage displayProtein ASevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)ChromatographyProteomicsScaffold proteinBiochemistryComputational biologyMedicineBiologyProtein purificationHuman proteome projectCell biology
193Publications
41H-index
15.6kCitations
Publications 196
Newest
#1Mei Ding (AstraZeneca)H-Index: 5
#2Rajneesh Malhotra (AstraZeneca)H-Index: 5
Last. Ida Isaksson (AstraZeneca)
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Regulatory T cells (Tregs) are the key cells regulating peripheral autoreactive T lymphocytes. Tregs exert their function by suppressing effector T cells. Tregs have been shown to play essential roles in the control of a variety of physiological and pathological immune responses. However, Tregs are unstable and can lose the expression of FOXP3 and suppressive functions as a consequence of outer stimuli. Available literature suggests that secreted proteins regulate Treg functional states, such as...
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#1Sebastian Havervall (KI: Karolinska Institutet)H-Index: 7
#2Marking U (KI: Karolinska Institutet)H-Index: 1
Last. Jonas Klingstrom (Public Health Agency of Sweden)
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Background: SARS-CoV-2 variants, such as Alpha, Beta, Gamma and Delta, are raising concern about the efficiency of neutralizing antibodies (NAb) induced by wild-type infection or vaccines based on the wild-type spike. Methods: We determined IgG and NAb against SARS-CoV-2 variants one year following mild wild-type infection (n=104) and two-dose regimens with BNT162b2 (BNT/BNT) (n=67), ChAdOx1 (ChAd/ChAd) (n=82), or heterologous ChAdOx1 followed by BNT162b2 (ChAd/BNT) (n=116). Findings: Wild type ...
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#1Sebastian Havervall (KI: Karolinska Institutet)H-Index: 7
#2Marking U (KI: Karolinska Institutet)H-Index: 1
Last. Sara M. Mangsbo (Science for Life Laboratory)H-Index: 21
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Abstract null null Background null Recent reports demonstrate robust serological responses to a single dose of messenger RNA (mRNA) vaccines in individuals previously infected with SARS-CoV-2. Data on immune responses following a single-dose adenovirus-vectored vaccine expressing the SARS-CoV-2 spike protein (ChAdOx1 nCoV-19) in individuals with previous SARS-CoV-2 infection are however limited, and current guidelines recommend a two-dose regimen regardless of preexisting immunity. null null nul...
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#1Susanna Klevebro (KI: Karolinska Institutet)H-Index: 5
Last. Gang Wang (Sichuan University)H-Index: 1
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AIM: We aimed to assess prevalence of IgG antibodies to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and factors associated with seropositivity in a large cohort of healthcare workers (HCWs). METHODS: From 11 May until 11 June 2020, 3981 HCWs at a large Swedish emergency care hospital provided serum samples and questionnaire data. Presence of IgG antibodies to SARS-CoV-2 was measured as an indicator of SARS-CoV-2 exposure. RESULTS: The total seroprevalence was 18% and increased d...
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#1Thomas Åkerlund (Public Health Agency of Sweden)H-Index: 2
#2Zakikhany K (Public Health Agency of Sweden)
Last. Nina Lagerqvist (Public Health Agency of Sweden)H-Index: 10
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More knowledge regarding persistence of antibody response to SARS-CoV-2 infections in the general population with mild symptoms is needed. We measured and compared levels of SARS-CoV-2 spike- and nucleocapsid-specific IgG-antibodies in serum samples from 145 laboratory-confirmed COVID-19 cases and 324 non-cases. The IgG-antibody levels against the spike protein in cases were stable over the time-period studied (14 to 256 days), while antibody levels against the nucleocapsid protein decreased ove...
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#1Sebastian Havervall (KI: Karolinska Institutet)H-Index: 7
#2Axel Rosell (KI: Karolinska Institutet)H-Index: 4
Last. Charlotte Thålin (KI: Karolinska Institutet)H-Index: 11
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This cohort study describes COVID-19–related symptoms persisting 8 months after SARS-CoV-2 infection among Swedish health care workers and self-reported effects of the residual symptoms on respondents’ home, work, and social function.
27 CitationsSource
#1Hassan Alkharaan (KI: Karolinska Institutet)H-Index: 3
#2Shaghayegh Bayati (KTH: Royal Institute of Technology)H-Index: 2
Last. Margaret Chen (KI: Karolinska Institutet)H-Index: 24
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Background Declining humoral immunity in COVID-19 patients and the possibility of reinfection have raised concern. Mucosal immunity, particularly salivary antibodies, may be short-lived although long-term studies are lacking. Methods Using a multiplex bead-based array platform, we investigated antibodies specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins in 256 saliva samples from convalescent patients 1-9 months after symptomatic COVID-19 (n=74, Cohort 1), undiagn...
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#1Sebastian Havervall (KI: Karolinska Institutet)H-Index: 7
#2Marking U (KI: Karolinska Institutet)H-Index: 1
Last. Charlotte Thålin (KI: Karolinska Institutet)H-Index: 11
view all 15 authors...
Background Recent reports demonstrate robust serological responses to a single dose of messenger RNA (mRNA) vaccines in individuals previously infected with SARS-CoV-2. Data on immune responses following a single-dose adenovirus-vectored vaccine expressing the SARS-CoV-2 spike protein (ChAdOx1 nCoV-19) in individuals with previous SARS-CoV-2 infection are however limited, and current guidelines recommend a two-dose regime regardless of preexisting immunity. Methods We compared spike-specific IgG...
4 CitationsSource
#1Nastya KharlamovaH-Index: 6
#2Nicky DunnH-Index: 4
Last. Anna Fogdell-HahnH-Index: 27
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Patients with chronic inflammatory diseases are often treated with immunosuppressants and therefore are of particular concern during the SARS-CoV-2 pandemic. Serological tests will improve our understanding of the infection and immunity in this population, unless they tests give false positive results. The aim of this study was to evaluate the specificity of SARS-Cov-2 serological assays using samples from patients with chronic inflammatory diseases collected prior to April 2019, thus defined as...
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#1Sadaf Sakina Hassan (KI: Karolinska Institutet)H-Index: 1
#2A. SeigerudH-Index: 1
Last. Joakim Dillner (KI: Karolinska Institutet)H-Index: 105
view all 14 authors...
BACKGROUND: In Sweden, home care services is a major external contact for older persons. METHODS: Five home care service companies in Stockholm, Sweden, enrolled 405 employees to a study including serum IgG to SARS-CoV-2 and SARS-CoV-2 virus in throat swabs. RESULTS: 20.1% (81/403) of employees were seropositive, about twice as many as in a simultaneously enrolled reference population (healthcare workers entirely without patient contact, n = 3671; 9.7% seropositivity). 13/379 employees (3.4%) ha...
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