Flurin Cathomas
University of Zurich
PsychopathologyInternal medicineEndocrinologyOncologyHippocampal formationPsychologySocial stressNeuroscienceImmunologyBipolar disorderApathyKynurenine pathwayInflammationKynurenineChronic stressDepression (differential diagnoses)AmygdalaAntidepressantSocial defeatMajor depressive disorderIn patientPeripheralAudiologyAnxietyMedicineSchizophreniaBiologyImmune system
Publications 31
#8Mariia Kaliuzhna (Geneva College)
#8Mariia Kaliuzhna (Geneva College)H-Index: 10
Abstract null null Background null Schizophrenia (SZ) and major depressive disorders (MDD) have been frequently linked to anatomical brain alterations. However, the relationship between brain pathology, inflammation and clinical symptoms in these disorders is still unclear. Thus, by applying novel blood markers of neuroaxonal integrity such as neurofilament light chain (NfL), we can now address main issues in psychiatric research and potentially offer innovative diagnostic tools toward better cl...
#1Flurin Cathomas (UZH: University of Zurich)H-Index: 11
#2Karoline Guetter (UZH: University of Zurich)H-Index: 3
Last. Stefan Kaiser (Geneva College)H-Index: 28
view all 5 authors...
Tryptophan and its catabolites (TRYCATs) have been suggested to link peripheral immune system activation and central neurotransmitter abnormalities with relevance to the etio-pathophysiology of schizophrenia (SZ) and major depressive disorder (MDD). The relationship to different psychopathological dimensions within these disorders however remains to be elucidated. We thus investigated potential group differences of tryptophan, kynurenine, kynurenic acid, 3-hydroxy kynurenine and quinolinic acid ...
#1Aki Takahashi (Rockefeller University)H-Index: 22
#2Hossein Aleyasin (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 23
Last. Scott J. Russo (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 77
view all 21 authors...
Heightened aggressive behavior is considered as one of the central symptoms of many neuropsychiatric disorders including autism, schizophrenia, and dementia. The consequences of aggression pose a heavy burden on patients and their families and clinicians. Unfortunately, we have limited treatment options for aggression and lack mechanistic insight into the causes of aggression needed to inform new efforts in drug discovery and development. Levels of proinflammatory cytokines in the periphery or c...
Last. Caroline MenardH-Index: 23
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Prevalence, symptoms, and treatment of depression all point toward major sex differences. Social stress-induced neurovascular pathology is associated with depressive symptoms in male mice however it remains unknown if it contributes to this sexual dimorphism. Here, we report that chronic social and subchronic variable stress promoted sex-specific blood-brain barrier (BBB) molecular and morphological alterations in mood-related brain regions. Viral-mediated functional manipulation leading to a ta...
#1Flurin Cathomas (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 11
#2Federica Klaus (UCSD: University of California, San Diego)H-Index: 5
Last. Philippe N. Tobler (UZH: University of Zurich)H-Index: 40
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One aspect of goal-directed behavior, which is known to be impaired in patients with schizophrenia (SZ), is balancing between exploiting a familiar choice with known reward value and exploring a lesser known, but potentially more rewarding option. Despite its relevance to several symptom domains of SZ, this has received little attention in SZ research. In addition, while there is increasing evidence that SZ is associated with chronic low-grade inflammation, few studies have investigated how this...
3 CitationsSource
#1Federica Klaus (UCSD: University of California, San Diego)H-Index: 5
#1Federica Klaus (UCSD: University of California, San Diego)H-Index: 1
Last. Stefan Kaiser (Geneva College)H-Index: 28
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Abstract Increasing evidence points to a causal involvement of inflammation in the pathogenesis of neuropsychiatric disorders, including major depressive disorder (MDD) and schizophrenia (SZ). Neopterin and biopterin may link peripheral immune system activation and central neurotransmitter alterations. However, it is not fully established whether these alterations are transdiagnostic or disorder-specific and whether they are associated with reward-related psychopathologies. We investigated group...
2 CitationsSource
#1Johannes Vetter (UZH: University of Zurich)H-Index: 2
#2Tobias R. Spiller (UZH: University of Zurich)H-Index: 5
Last. Birgit Kleim (UZH: University of Zurich)H-Index: 24
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Abstract Background The higher prevalence of major depressive disorder (MDD) in females relative to males is well-established. Some authors have posited this difference arises to divergent symptom profiles in females vs. males. However, empirical tests of this hypothesis have yielded equivocal results. Here, we investigate sex differences in MDD of individual symptoms and symptom networks in a treatment-seeking sample. Methods We assessed depressive symptoms using Hamilton Depression Rating Scal...
4 CitationsSource