Chikashi Terao
Kyoto University
GeneGenome-wide association studyInternal medicineSingle-nucleotide polymorphismAntibodyAutoantibodyAlleleGenetic associationHuman leukocyte antigenImmunologyRheumatoid factorArthritisRheumatoid arthritisDiseasePopulationGeneticsMedicineCohortLocus (genetics)Biology
Publications 156
#1Niamh Mullins (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 17
#2Andreas J. Forstner (University of Marburg)H-Index: 5
Last. Ole A. Andreassen (University of Oslo)H-Index: 125
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Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. Bipolar disorder risk alleles were enriched in genes in synaptic signaling pathways and brain-expressed genes, particularly those with high specificity of expression in neurons of the prefrontal cortex and hippocampus. Significant signal enrichment was found in ge...
2 CitationsSource
#1Yoshie Gon (Kyoto University)H-Index: 2
#2Hajime Yoshifuji (Kyoto University)H-Index: 24
Last. Chikashi Terao (Kyoto University)H-Index: 31
view all 8 authors...
Objectives: Biologics have been used to treat refractory Takayasu arteritis (TAK), but their efficacy and safety have not been sufficiently evaluated.Methods: We extracted clinical information from...
3 CitationsSource
#1Mineto Ota (UTokyo: University of Tokyo)H-Index: 4
#2Yasuo Nagafuchi (UTokyo: University of Tokyo)H-Index: 11
Last. Keishi Fujio (UTokyo: University of Tokyo)H-Index: 29
view all 41 authors...
Summary Genetic studies have revealed many variant loci that are associated with immune-mediated diseases. To elucidate the disease pathogenesis, it is essential to understand the function of these variants, especially under disease-associated conditions. Here, we performed a large-scale immune cell gene-expression analysis, together with whole-genome sequence analysis. Our dataset consists of 28 distinct immune cell subsets from 337 patients diagnosed with 10 categories of immune-mediated disea...
#1Xianyong YinH-Index: 1
#1Xianyong YinH-Index: 26
Last. Sang Cheol Bae (Hanyang University)H-Index: 89
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Objective Systemic lupus erythematosus (SLE), an autoimmune disorder, has been associated with nearly 100 susceptibility loci. Nevertheless, these loci only partially explain SLE heritability and their putative causal variants are rarely prioritised, which make challenging to elucidate disease biology. To detect new SLE loci and causal variants, we performed the largest genome-wide meta-analysis for SLE in East Asian populations. Methods We newly genotyped 10 029 SLE cases and 180 167 controls a...
8 CitationsSource
#1Toshimitsu Suzuki (Nagoya City University)H-Index: 22
#2Yoshinao Koike (Hokkaido University)H-Index: 2
Last. Kazuhiro Yamakawa (Nagoya City University)H-Index: 60
view all 13 authors...
Objective Although a number of genes responsible for epilepsy have been identified through Mendelian genetic approaches, and genome-wide association studies (GWASs) have implicated several susceptibility loci, the role of ethnic-specific markers remains to be fully explored. We aimed to identify novel genetic associations with epilepsy in a Japanese population. Methods We conducted a GWAS on 1825 patients with a variety of epilepsies and 7975 control individuals. Expression quantitative trait lo...
#1Marialbert Acosta-Herrera (CSIC: Spanish National Research Council)H-Index: 11
#2Martin Kerick (CSIC: Spanish National Research Council)H-Index: 23
Last. Javier Martín (CSIC: Spanish National Research Council)H-Index: 71
view all 22 authors...
Objective The greatest genetic effect reported for systemic sclerosis (SSc) lies in the major histocompatibility complex (MHC) locus. Leveraging the largest SSc genome-wide association study, we aimed to fine-map this region to identify novel human leucocyte antigen (HLA) genetic variants associated with SSc susceptibility and its main clinical and serological subtypes. Methods 9095 patients with SSc and 17 584 controls genome-wide genotyped were used to impute and test single-nucleotide polymor...
#1Nao Tanaka (Tokyo Medical and Dental University)
#2Chikashi TeraoH-Index: 31
Last. Fumitaka Mizoguchi (Tokyo Medical and Dental University)H-Index: 14
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#1Kohei Saito (Keio: Keio University)H-Index: 1
#2Norimoto GotohH-Index: 32
Last. Chikashi TeraoH-Index: 31
view all 6 authors...
Retinitis pigmentosa (RP) is a heterogenous hereditary disorder leading to blindness. Despite using next-generation sequencing technologies, causal variants in about 60% of RP cases remain unknown. The heterogeneous genetic inheritance pattern makes it difficult to pinpoint causal variants. Besides, rare penetrating variants are hardly observed in general case-control studies. Thus, a family-based analysis, specifically in a consanguineous family, is a clinically and genetically valuable approac...
#1Keiichiro Kadoba (Kyoto University)H-Index: 1
#2Ryu Watanabe (Kyoto University)H-Index: 19
Last. Hajime Yoshifuji (Kyoto University)H-Index: 24
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#1Mark K Bakker (UU: Utrecht University)H-Index: 2
#2Rick A.A. van der Spek (UU: Utrecht University)H-Index: 11
Last. Ynte M. RuigrokH-Index: 26
view all 76 authors...