Andrés de la Escosura
Autonomous University of Madrid
Electron transferBiophysicsNanoparticleFullereneNanotechnologyCovalent bondAqueous solutionChemistryNanostructurePolymer chemistryAbiogenesisMaterials scienceCombinatorial chemistrySelf-assemblySinglet oxygenPhthalocyaninePhotoinduced electron transferPhotodynamic therapyPhotosensitizerMoleculeAmphiphilePhotochemistryFluorescenceSupramolecular chemistry
Publications 49
#1Verónica Almeida-Marrero (UAM: Autonomous University of Madrid)H-Index: 2
#2Marta Mascaraque (UAM: Autonomous University of Madrid)H-Index: 6
Last. Andrés de la Escosura (UAM: Autonomous University of Madrid)H-Index: 23
view all 6 authors...
In the endeavor of extending the clinical use of photodynamic therapy (PDT) for the treatment of superficial cancers and other neoplastic diseases, deeper knowledge and control on the subcellular processes that determine the response of photosensitizers (PS) are needed. Recent strategies in this direction involve the use of activatable and nanostructured PS. Herein both capacities have been tuned in two dendritic zinc (II) phthalocyanine (ZnPc) derivatives, either asymmetrically or symmetrically...
#1Asma Rahali (UAM: Autonomous University of Madrid)
#1Asma Rahali (Carthage University)
Last. Eduardo Anaya-Plaza (Aalto University)H-Index: 8
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Design and synthesis of novel photosensitizer architectures is a key step toward new multifunctional molecular materials. Photoactive Janus-type molecules provide interesting building blocks for such systems by presenting two well-defined chemical functionalities that can be utilized orthogonally. Herein a multifunctional phthalocyanine is reported, bearing a bulky and positively charged moiety that hinders their aggregation while providing the ability to adhere on DNA origami nanostructures via...
#1Anil Kumar Bandela (BGU: Ben-Gurion University of the Negev)H-Index: 1
#2Nathaniel Wagner (BGU: Ben-Gurion University of the Negev)H-Index: 16
Last. Gonen Ashkenasy (BGU: Ben-Gurion University of the Negev)H-Index: 26
view all 9 authors...
Many fundamental cellular and viral functions, including replication and translation, involve complex ensembles hosting synergistic activity between nucleic acids and proteins/peptides. There is ample evidence indicating that the chemical precursors of both nucleic acids and peptides could be efficiently formed in the prebiotic environment. Yet, studies on nonenzymatic replication, a central mechanism driving early chemical evolution, have focused largely on the activity of each class of these m...
2 CitationsSource
#1Marie Halaskova (Charles University in Prague)H-Index: 1
#2Asma Rahali (UAM: Autonomous University of Madrid)H-Index: 1
Last. Petr Zimcik (Charles University in Prague)H-Index: 23
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Photodynamic therapy is a treatment modality of cancer based on the production of cytotoxic species upon the light activation of photosensitizers. Zinc phthalocyanine photosensitizers bearing four ...
1 CitationsSource
#1Carlos BrionesH-Index: 4
#2I. Jimenez-SerraH-Index: 7
Last. Jordi GómezH-Index: 26
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#2Jan Joseph (FAU: University of Erlangen-Nuremberg)H-Index: 2
Last. Tomás Torres (IMDEA)H-Index: 97
view all 12 authors...
#1Tomás Torres (UAM: Autonomous University of Madrid)H-Index: 97
#1Eduardo Anaya-Plaza (UAM: Autonomous University of Madrid)H-Index: 8
Last. Dirk M. Guldi (FAU: University of Erlangen-Nuremberg)H-Index: 113
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In the scientific race to build up photoactive electron donor-acceptor systems with increasing efficiencies, little is known about the interplay of their building blocks when integrated into supramolecular nanoscale arrays, particularly in aqueous environments. Here, we describe an aqueous donor-acceptor ensemble whose emergence as a nanoscale material renders it remarkably stable and efficient. We have focused on a tetracationic zinc phthalocyanine (ZnPc) featuring pyrenes, which shows an unpre...
3 CitationsSource
#1Ahmed Shaukat (Aalto University)H-Index: 3
#2Eduardo Anaya-Plaza (Aalto University)H-Index: 8
Last. Mauri A. Kostiainen (Aalto University)H-Index: 36
view all 7 authors...
In this communication, electrostatically assembled phthalocyanine (Pc)-DNA origami (DO) complexes are formed and their optical properties are demonstrated. The formation of the complex prevents the Pc aggregation, thus yielding an enhanced optical response and photooxidative resilience towards aggregation in biologically-related media. Simultaneously, the Pc protects the DO against enzymatic digestion. Both features solve previous drawbacks associated with phthalocyanine photosensitizers and DNA...
5 CitationsSource
Last. Tomás TorresH-Index: 97
view all 11 authors...
#1Sara Morales‐Reina (UAM: Autonomous University of Madrid)H-Index: 2
#2Chandan Giri (UAM: Autonomous University of Madrid)H-Index: 10
Last. Andrés de la Escosura (UAM: Autonomous University of Madrid)H-Index: 23
view all 8 authors...
One of the major goals in systems chemistry is to create molecular assemblies with emergent properties that are characteristic of life. An interesting approach toward this goal is based on merging different biological building blocks into synthetic systems with properties arising from the combination of their molecular components. The covalent linkage of nucleic acids (or their constituents: nucleotides, nucleosides and nucleobases) with lipids in the same hybrid molecule leads, for example, to ...
1 CitationsSource