Nagarajan Selvamurugan
SRM University
GeneInternal medicineBiomedical engineeringmicroRNAMolecular biologyChemistryMaterials scienceMesenchymal stem cellRUNX2OsteoblastChitosanParathyroid hormoneBone regenerationBone tissue engineeringChemical engineeringTissue engineeringCancer researchTranscription factorBiologyProtein adsorptionCell biology
160Publications
59H-index
9,002Citations
Publications 152
Newest
#1M. RohiniH-Index: 2
#2M. GokulnathH-Index: 3
Last. Nagarajan SelvamuruganH-Index: 59
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Abstract We previously reported that ATF3 and Runx2 are involved in breast cancer progression and bone metastasis. The expression of these genes can be controlled by post-transcriptional regulators such as microRNAs (miRNAs). In this study, we identified and validated the functional role of miR-590–3p in human breast cancer cells (MDA-MB231). There was an inverse correlation between the expression of miR-590–3p and its putative target genes, ATF3 and Runx2 in these cells. Overexpression of miR-5...
24 CitationsSource
Abstract Trans-anethole (TA) is a phenolic phytocompound widely used in the food and health sector because of its diverse biological properties. However, its role in the promotion of bone formation is not known. With the enhanced bioavailability of TA, we aimed to determine its effect on osteogenesis; TA at different concentrations (5, 10, and 20 μM) was loaded onto polycaprolactone (PCL)/polyvinylpyrrolidone (PVP) fibers by the electrospinning technique. The synthesized PCL/PVP + TA fibers were...
16 CitationsSource
Abstract In the recent years, a paradigm shift is taking place where metallic/synthetic implants and tissue grafts are being replaced by tissue engineering approach. A well designed three-dimensional scaffold is one of the fundamental tools to guide tissue formation in vitro and in vivo. Bone is a highly dynamic and an integrative tissue, and thus enormous efforts have been invested in bone tissue engineering to design a highly porous scaffold which plays a critical role in guiding bone growth a...
79 CitationsSource
#1Abdul Azeez Abdu Aliyu (Bayero University Kano)H-Index: 11
#2Ahmad Majdi Abdul-Rani (Petronas)H-Index: 9
Last. Sandipan Roy (Techno India)H-Index: 8
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ABSTRACTTo suit a target application, the machining mechanism of electro discharge machining (EDM) process has been hybridized to powder mixed EDM (PM-EDM) by adding various substances in the form of additives into the dielectric fluid. In this study, the application of PM-EDM to fabricate Lakargiite (CaZrO3) coating on Zr–Cu–Ni–Ti–Be substrate surface for potential orthopedic application, using hydroxyapatite (HA) powder as dielectric additive was proposed. The effect of various HA powder conce...
17 CitationsSource
Abstract Numerous phytochemical compounds have recently been reported to stimulate osteogenesis. In this study, the bioavailability and osteogenic effects of chrysin, a natural flavonoid, were investigated. Chrysin was incorporated at different concentrations into biocomposite scaffolds containing carboxymethyl cellulose, chitosan, and nano-hydroxyapatite, through the freeze-drying method. The physicochemical and material characteristics of chrysin-incorporated scaffolds were investigated, and c...
21 CitationsSource
: Parathyroid hormone (PTH) acts on osteoblasts and functions as an essential regulator of calcium homeostasis and as a mediator of bone remodeling. We previously reported that PTH stimulates the expression of matrix metalloproteinase-13 (MMP-13) in rat osteoblasts and that MMP-13 plays a key role in bone remodeling, endochondral bone formation, and bone repair. Recent evidence indicated that microRNAs (miRNAs) have regulatory functions in bone metabolism. In this study, we hypothesized that the...
11 CitationsSource
Abstract Bone tissue engineering (BTE) relies on biocomposite scaffolds and bioactive molecules for bone regeneration. The present study was aimed to synthesize and characterize biocomposite scaffolds containing chitosan (CS), nano-hydroxyapatite (nHAp) and nano‑zirconium dioxide (nZrO2) along with microRNA (miRNA) for BTE applications. miRNAs act as post-transcriptional regulator of gene expression. The fabricated biocomposite scaffolds were characterized using SEM, FT-IR and XRD analyses. The ...
28 CitationsSource
#1S. Saiganesh (SRM University)H-Index: 2
#2R. Saathvika (SRM University)H-Index: 2
Last. Nagarajan Selvamurugan (SRM University)H-Index: 59
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Abstract Bone remodeling is an orchestrated process involving osteoblasts and osteoclasts to maintain mineral homeostasis in the internal milieu, mediated chiefly by matrix metalloproteinases (MMPs). MMP13, one amongst the MMPs plays a premier role in bone remodeling, and mutations in MMP13 have been implicated in various pathologies including cancer and arthritis. Transcriptional activation of MMP13 gene is tightly regulated by several signaling cascade components. Post-transcriptional regulato...
6 CitationsSource
#1S. Dinesh Kumar (Chettinad Health City)H-Index: 1
#2K. Mohamed Abudhahir (Chettinad Health City)H-Index: 2
Last. A. Moorthi (Chettinad Health City)H-Index: 17
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Abstract The improvisation of the treatment procedures for treating the various kind of bone defects such as, bone or dental trauma and for diseases such as osteoporosis, osteomyelitis etc., need the suitable and promising biomaterials with resemblance of bone components. Bioactive glass ceramic (BGC) has recently acquired great attention as the most promising biomaterials; hence it has been widely applied as a filler material for bone tissue regeneration. Because it elicts specific biological r...
5 CitationsSource
#1Balasubramanian Arumugam (SRM University)H-Index: 1
#2M. Vairamani (SRM University)H-Index: 28
Last. Nagarajan Selvamurugan (SRM University)H-Index: 59
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Transforming growth factor-beta1 (TGF-β1), a highly abundant growth factor in skeletal tissues, stimulates matrix metalloproteinase-13 (MMP-13) expression in osteoblastic cells. MMP-13 plays a critical role in bone remodeling. Runx2, a bone transcription factor, is required for TGF-β1-mediated stimulation of MMP-13 expression in osteoblastic cells. In this study, the molecular mechanism responsible for TGF-β1-stimulation of MMP-13 expression via Runx2 in osteoblastic cells was elucidated. TGF-β1...
18 CitationsSource