Nagarajan Selvamurugan
SRM University
GenemicroRNAGene expressionMolecular biologyBone remodelingChemistryMaterials scienceMesenchymal stem cellRUNX2OsteoblastChitosanParathyroid hormoneBone regenerationChemical engineeringTissue engineeringCancer researchTranscription factorBiologyProtein adsorptionCell biology
Publications 150
#1Ganesh Sanjeev (SRM University)H-Index: 2
#2S. Pranavkrishna (SRM University)H-Index: 1
Last. Nagarajan Selvamurugan (SRM University)H-Index: 59
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Breast cancer (BC) is a critical health care issue that substantially affects women worldwide. Though surgery and chemotherapy can effectively control tumor growth, metastasis remains a primary concern. Metastatic BC cells predominantly colonize in bone, owing to their rigid osseous nutrient-rich nature. There are recently increasing studies investigating the context-dependent roles of non-coding RNAs (ncRNAs) in metastasis regulation. ncRNAs, including microRNAs, long non-coding RNAs, circular ...
The bone defects healing are always associated with post implantation infections; hence biomaterials rules significant role for orchestration of defective bone. In this study, we synthesized biocomposite scaffold by combining polycaprolactone (PCL), wollastonite (Ws) and metal ions (Cu) by electrospinning technique. The manufactured scaffolds (PCL/Ws andPCL/Cu-Ws) were subjected to physio-chemical characterization by scanning electron microscopy, energy dispersive X-ray spectroscopy, Fourier Tra...
1 CitationsSource
#1R. Abhinandan (SRM University)H-Index: 2
#2S. Pranav Adithya (SRM University)H-Index: 1
Last. Nagarajan Selvamurugan (SRM University)H-Index: 59
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Abstract Boride, which belongs to the distinct category of ceramic materials, has attracted significant attention in tissue engineering applications. Magnesium diboride (MgB2) consists of a plane of magnesium atoms sandwiched between the layers of boron. Even though MgB2 showed its role in various applications, its effect on osteogenesis has not yet been investigated. In this study, we synthesized MgB2 nanosheets (MgB2NS), a new class of 2D-nanoscale structures, by the ultrasonication exfoliatio...
Abstract Bone remodeling is a complex event that maintains bone homeostasis. The epigenetic mechanism of the regulation of bone remodeling has been a major research focus over the past decades. Histone acetylation is an influential post-translational modification in chromatin architecture. Acetylation affects chromatin structure by offering binding signals for reader proteins that harbor acetyl-lysine recognition domains. This review summarizes recent data of histone acetylation in bone remodeli...
#1Manju Mohan (University of Madras)
#2Sridhar Muthusami (Karpagam University)H-Index: 9
Last. Ilangovan Ramachandran (University of Madras)H-Index: 11
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Abstract Cellular senescence is a hallmark of aging that is characterized by irreversible cell cycle arrest in response to various stress stimuli. It is a normal physiological event, which plays essential role in development, prevention of cancer, wound healing process, etc. Nevertheless, accumulation of senescent cells is the trigger and forms the basis of aging of a tissue/organ and, thus, the organismal aging. During aging, cells display a senescence-associated secretory phenotype (SASP) that...
#1Mathew PeterH-Index: 5
#2Nitya GaneshH-Index: 4
Last. RV Jayakumar (AIMS: Amrita Institute of Medical Sciences and Research Centre)H-Index: 9
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#1A.S. SoubhagyaH-Index: 1
#2K. BalagangadharanH-Index: 10
Last. Mani PrabaharanH-Index: 32
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Three-dimensional (3D) porous films based on chitosan (CS)/carboxymethyl guar gum (CMGG) polyelectrolyte complex (PEC) containing titanium dioxide nanoparticles (TiO2 NPs) were prepared as a wound-healing material by the freeze-drying process. The physicochemical properties of these films were evaluated by FTIR, XRD, SEM and EDX analysis. Furthermore, the swelling degree, porosity, in vitro biodegradation and compression strength of these films were examined. The developed films showed the bioco...
#1K.T. ShalumonH-Index: 25
#2N.S. BinulalH-Index: 10
Last. RV JayakumarH-Index: 9
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Abstract Bone is a highly integrative and dynamic tissue of the human body that is regularly modeled and remodeled by bone cells such as osteoblasts and osteoclasts. When a fraction of a bone is damaged or deformed, stem cells and bone cells under the influence of several signaling pathways regulate bone regeneration at the particular locale, but in a dilatory manner. To overcome this problem, the field of bone tissue engineering (BTE) utilizes various bio-composite scaffolds that incorporate ce...
2 CitationsSource
#1Ravishkumar L Akshaya (SRM University)H-Index: 2
Last. Nagarajan Selvamurugan (SRM University)H-Index: 59
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Abstract We previously reported that activating transcription factor 3 (ATF3), an adaptive response gene, plays a dichotomous role in regulating several molecular processes during breast cancer progression. ATF3 promoted the expression of runt-related transcription factor 2 (Runx2, a metastatic gene) and activated matrix metalloproteinase 13 (MMP13, an invasive gene), thereby fostering proliferation and bone-metastasis of the breast cancer cells. Targeting ATF3 may mitigate the metastatic spread...