Francois Berthiaume
Rutgers University
EndocrinologyPathologyPerfusionChemistryImmunologyHepatocyteInflammationHypermetabolismLiver transplantationContext (language use)Wound healingStem cellTransplantationBurn injuryBiochemistryMetabolismBioartificial liver deviceMedicineBiologyCell biology
233Publications
53H-index
9,767Citations
Publications 212
Newest
#2Suneel KumarH-Index: 18
Last. Indu Pal KaurH-Index: 40
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The study aims to develop high drug-loaded (about 15% lipid matrix) curcumin solid lipid nanoparticles (CSLNs) for wound healing. CSLNs prepared by hot, high-pressure homogenization, without using organic solvents, were optimized using the Taguchi design followed by the central composite design. The optimized CSLNs exhibited a high assay/drug content (0.6% w/w), solubility (6 × 105 times), and EE (75%) with a particle size < 200 nm (PDI—0.143). The CSLNs were safe (in vitro and in vivo), photost...
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#1Hwan June Kang (RU: Rutgers University)H-Index: 2
#2Nuozhou Chen (RU: Rutgers University)H-Index: 1
Last. Francois Berthiaume (RU: Rutgers University)H-Index: 53
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Significance: Chronic wounds are one of the major burdens of the U.S. health care system with an annual cost of $31.7 billion and affecting an estimated 2.4–4.5 million people. Several underlying m...
1 CitationsSource
#1Hwan June Kang (RU: Rutgers University)H-Index: 2
#2Suneel Kumar (RU: Rutgers University)H-Index: 18
Last. Francois Berthiaume (RU: Rutgers University)H-Index: 53
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Abstract Chronic and non-healing skin wounds are some of the most significant complications in patients with advanced diabetes. A contributing mechanism to this pathology is the non-enzymatic glycation of proteins due to hyperglycemia, leading to the formation of advanced glycation end products (AGEs). AGEs bind to the receptor for AGEs (RAGE), which triggers pro-inflammatory signals that may inhibit the proliferative phase of wound healing. Soluble forms of RAGE (sRAGE) may be used as a competi...
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#1Francois Berthiaume (RU: Rutgers University)H-Index: 53
Emerging pathogens have no known therapies or vaccines and therefore can only be controlled via traditional methods of contact tracing, quarantine and isolation that require rapid and widespread te...
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#1Suneel KumarH-Index: 18
#2Yuying TanH-Index: 5
Last. Francois BerthiaumeH-Index: 53
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Pressure ulcers (PUs) or sores are a secondary complication of diabetic neuropathy and traumatic spinal cord injury (SCI). PUs tend to occur in soft tissues located around bony prominences and may heal slowly or not at all. A common mechanism underlying impaired healing of PUs may be dysfunction of the local neurovascular system including deficiency of essential neuropeptides, such as substance P (SP). Previous studies indicate that disturbance in cutaneous sensory innervation leads to a defect ...
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#1Anika HaqH-Index: 5
#2Suneel Kumar (RU: Rutgers University)H-Index: 18
Last. Bozena Michniak-KohnH-Index: 27
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The purpose of this study was to synthesize and characterize novel biocompatible topical polymeric film and hydrogel systems that have the potential to deliver the antibacterial agent thymoquinone (TQ) directly to the skin target site to manage the local wound infection and thereby wound healing. The polyvinyl pyrrolidone (PVP) matrix-type films containing TQ were prepared by the solvent casting method. In vitro skin permeation studies on human cadaver skin produced a mean flux of 2.3 µg TQ/cm2/...
2 CitationsSource
#1Thomas Theis (RU: Rutgers University)H-Index: 6
#2Suneel Kumar (RU: Rutgers University)H-Index: 18
Last. Melitta Schachner (RU: Rutgers University)H-Index: 152
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Myristoylated alanine-rich C-kinase substrate (MARCKS) is an intracellular receptor for polysialic acid. MARCKS supports development, synaptic plasticity, and regeneration after injury. MARCKS binds with its functionally essential effector domain (ED) to polysialic acid. A 25-mer peptide comprising the ED of MARCKS stimulates neuritogenesis of primary hippocampal neurons after addition to the culture. This motivated us to investigate whether ED peptide has similar effects in spinal cord injury. ...
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#1Paulina Krzyszczyk (RU: Rutgers University)H-Index: 4
#2Hwan June Kang (RU: Rutgers University)H-Index: 2
Last. Francois Berthiaume (RU: Rutgers University)H-Index: 53
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: Nonhealing wounds possess elevated numbers of pro-inflammatory M1 macrophages, which fail to transition to anti-inflammatory M2 phenotypes that promote healing. Hemoglobin (Hb) and haptoglobin (Hp) proteins, when complexed (Hb-Hp), can elicit M2-like macrophages through the heme oxygenase-1 (HO-1) pathway. Despite the fact that nonhealing wounds are chronically inflamed, previous studies have focused on non-inflammatory systems, and do not thoroughly compare the effects of complexed vs individ...
2 CitationsSource
#1Bodhisatwa Das (RU: Rutgers University)H-Index: 2
#2Anil B. Shrirao (RU: Rutgers University)H-Index: 8
Last. Martin L. Yarmush (RU: Rutgers University)H-Index: 104
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Background: High-powered pulsed electric fields (PEF) may be used for tissue debridement and disinfection, while lower PEF intensities may stimulate beneficial cellular responses for wound healing....
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#1Olivier Thierry Guenat (University of Bern)H-Index: 18
#2Thomas Geiser (University of Bern)H-Index: 39
Last. Francois Berthiaume (RU: Rutgers University)H-Index: 53
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Organs-on-chips (OOC) are widely seen as being the next generation in vitro models able to accurately recreate the biochemical-physical cues of the cellular microenvironment found in vivo. In addit...
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