Michael T. Nurmohamed
University of Amsterdam
Internal medicineSurgeryPhysical therapyProspective cohort studyRheumatologyImmunologyPsoriatic arthritisInflammationArthritisEtanerceptAnkylosing spondylitisRheumatoid arthritisDiseaseAdalimumabMethotrexatePopulationIn patientMedicineCohortGastroenterology
Publications 340
Patient-reported outcomes (PROs) on adverse drug reactions (ADRs) are increasingly used in cohort event monitoring (CEM) to obtain a better understanding of patients’ real-world experience with dru...
#1Marit Stockfelt (Sahlgrenska University Hospital)H-Index: 3
#2Anna-Carin Lundell (University of Gothenburg)H-Index: 14
Last. Dan Nordström (UH: University of Helsinki)H-Index: 31
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The type I interferon (IFN) gene signature is present in a subgroup of patients with early rheumatoid arthritis (RA). Protein levels of IFNα have not been measured in RA and it is unknown whether they associate with clinical characteristics or treatment effect. Patients with early untreated RA (n = 347) were randomized to methotrexate combined with prednisone, certolizumab-pegol, abatacept, or tocilizumab. Plasma IFNα protein levels were determined by single molecular array (Simoa) before and 24...
#1R. Agca (VUmc: VU University Medical Center)H-Index: 5
Last. Michael T. Nurmohamed (VUmc: VU University Medical Center)H-Index: 63
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OBJECTIVE RA is associated with higher risk of cardiovascular (CV) disease. Ongoing systemic inflammation is presumed to accelerate atherosclerosis by increasing inflammation in the arterial wall. However, evidence supporting this hypothesis is limited. We aimed to investigate arterial wall inflammation in RA vs OA, and its association with markers of inflammation and CV risk factors. METHODS 18-fluorodeoxyglucose PET combined with CT (18F-FDG-PET/CT) was performed in RA (n = 61) and OA (n = 28)...
3 CitationsSource
#1Laura Boekel (UvA: University of Amsterdam)H-Index: 2
#2Maurice SteenhuisH-Index: 2
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Introduction: Data on immunogenicity of SARS-CoV-2 vaccines in patients with autoimmune diseases are still scarce, because these patients were largely excluded from SARS-CoV-2 vaccine trials. Methods: Serum samples of patients with autoimmune diseases (n = 480) and healthy controls (n = 204) included in two ongoing prospective cohort studies were collected after first or second SARS-CoV-2 vaccinations. Seroconversion rates and IgG antibody titers against the receptor-binding domain (RBD) of the ...
#1Josef S Smolen (Medical University of Vienna)H-Index: 109
#2Stefan Siebert (Glas.: University of Glasgow)H-Index: 25
Last. Michael T. Nurmohamed (VUmc: VU University Medical Center)H-Index: 63
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Objectives: To evaluate 6-month effectiveness of ustekinumab versus tumour necrosis factor inhibitor (TNFi), analysing predictors of low disease activity (LDA)/remission. Methods: PsABio is a prospective, observational cohort study of patients with psoriatic arthritis (PsA) at 92 sites in eight European countries, who received first-line to third-line ustekinumab or a TNFi. Comparative achievement at 6 months of clinical Disease Activity Index for Psoriatic Arthritis (cDAPSA) LDA/remission, and ...
#2Sadaf AtiqiH-Index: 2
Last. Alfons A den Broeder (Radboud University Nijmegen)H-Index: 31
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A substantial proportion of rheumatoid arthritis (RA) patients discontinues treatment with tumour necrosis factor inhibitors (TNFi) due to inefficacy or intolerance. After the failure of treatment with a TNFi, treatment can be switched to another TNFi or a bDMARD with a different mode of action (non-TNFi). Measurement of serum drug concentrations and/or anti-drug antibodies (therapeutic drug monitoring (TDM)) may help to inform the choice for the next step. However, the clinical utility of TDM t...
1 CitationsSource
#1Daisy Vedder (VU: VU University Amsterdam)H-Index: 2
#2Martijn GerritsenH-Index: 14
Last. Christian Lood (UW: University of Washington)H-Index: 26
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OBJECTIVE To investigate the association between neutrophil activation and cardiovascular risk in gout patients. We hypothesize that neutrophil activation mediates inflammation and therefore takes part in atherogenesis in gout patients. METHOD Patient data were collected from 75 consecutive gout patients participating in the Reade gout cohort Amsterdam. Levels of neutrophil extracellular traps (NETs) and neutrophil activation (calprotectin and peroxidase activity) were analysed by ELISA and fluo...
2 CitationsSource
#1R. AltenH-Index: 7
#2Xavier Mariette (Université Paris-Saclay)H-Index: 117
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#1Peter C. TaylorH-Index: 69
#2C. Charles-Schoeman (UCLA Medical Center)H-Index: 1
Last. G.-R. BurmesterH-Index: 57
view all 11 authors...
#1R. AltenH-Index: 7
#2Xavier Mariette (Université Paris-Saclay)H-Index: 117
view all 18 authors...