Patrick J Twomey
University College Dublin
StatisticsVitamin D and neurologyInternal medicineEndocrinologySurgeryPathologyIntensive care medicineChemistryKidney diseaseDiseasePregnancyCeruloplasminPopulationIn patientMathematicsConfidence intervalMedical laboratoryCopperDiabetes mellitusMedicineGastroenterology
Publications 137
Last. Patrick J Twomey (UCD: University College Dublin)H-Index: 22
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Estimates of glomerular filtration rate (eGFR) help assess kidney function. Estimated GFR can be used to classify patients into one of six Chronic Kidney Disease (CKD) categories as recommended by the Kidney Disease Improving Global Outcomes clinical practice guidelines; CKD1 ≥90, CKD2 60–89, CKD3a 45–59, CKD3b 30–44, CKD4 15–29 or CKD5 ≤15 mL/min/1.73 m2. The Modification of Diet and Renal Disease (MDRD) study formula was widely adopted to calculate eGFR. The CKD Epidemiology Collaboration (CKD...
#1Stephen A. Wise (NIST: National Institute of Standards and Technology)H-Index: 5
#2Johanna E. Camara (NIST: National Institute of Standards and Technology)H-Index: 13
Last. Christian PoppH-Index: 1
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An interlaboratory comparison study was conducted by the Vitamin D Standardization Program (VDSP) to assess the performance of ligand binding assays (Part 2) for the determination of serum total 25-hydroxyvitamin D [25(OH)D]. Fifty single-donor samples were assigned target values for concentrations of 25-hydroxyvitamin D2 [25(OH)D2], 25-hydroxyvitamin D3 [25(OH)D3], 3-epi-25-hydroxyvitamin D3 [3-epi-25(OH)D3], and 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] using isotope dilution liquid chromatog...
2 CitationsSource
#1Jayne DohertyH-Index: 3
#2Rebecca L. MooreH-Index: 3
Last. Fionnuala M. McAuliffeH-Index: 57
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#2Patrick J Twomey (UCD: University College Dublin)H-Index: 22
Last. Ingrid Borovickova (TU: Temple University)H-Index: 1
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This case describes a 15-month boy with a 6-month history suggestive of liver disease. His similarly affected non-identical twin died and autopsy investigations were consistent with intrahepatic cholestasis, progressive liver damage complicated by cirrhosis/portal hypertension and vitamin D deficient rickets. Cholestasis is common in liver disease.1 Familial cholestasis can be limited geographically/ethnically: Greenland Eskimo cholestasis, North American Indian cirrhosis, Turkish non-syndromic ...
#2Rachel K Crowley (UCD: University College Dublin)H-Index: 17
Last. Fionnuala M. McAuliffe (UCD: University College Dublin)H-Index: 57
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Abstract null null Objectives null Clinical studies have reported an inverse relationship between calcium and vitamin D intake and hypertensive disorders of pregnancy (HDP). The aim of this study was to investigate if there was an association between calcium/vitamin D intake, and vitamin D (25OHD) status, and maternal blood pressure (BP), during pregnancy and at 5-year follow-up. null null null Study Design null This was an observational study of 415 women who participated in the ROLO (Randomise...
#1Johanna E. Camara (NIST: National Institute of Standards and Technology)H-Index: 13
#2Stephen A. Wise (NIH: National Institutes of Health)H-Index: 5
Last. Adam Kuszak (NIH: National Institutes of Health)H-Index: 10
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An interlaboratory study was conducted through the Vitamin D Standardization Program (VDSP) to assess commutability of Standard Reference Materials® (SRMs) and proficiency testing/external quality assessment (PT/EQA) samples for determination of serum total 25-hydroxyvitamin D [25(OH)D] using ligand binding assays and liquid chromatography-tandem mass spectrometry (LC-MS/MS). A set of 50 single-donor serum samples were assigned target values for 25-hydroxyvitamin D2 [25(OH)D2] and 25-hydroxyvita...
#1Mark Kilbane (UCD: University College Dublin)H-Index: 13
#2Rachel K CrowleyH-Index: 17
Last. Patrick J TwomeyH-Index: 22
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Parathyroid hormone-related protein (PTHrP) can simulate most of the actions of parathyroid hormone (PTH) including increases in bone resorption and distal tubular calcium reabsorption and inhibition of proximal tubular phosphate transport.1 The low serum phosphate in parallel with low circulating PTH is consistent with PTHrP involvement in this case. Whether it can be causative for a serum calcium of 6.24 mmol/L however is a moot point. While the mechanism underlying the patient’s severe hyperc...
#1Aoife Garrahy (UCD: University College Dublin)H-Index: 7
#2Iona Galloway (UCD: University College Dublin)H-Index: 1
Last. CJ Thompson (UCD: University College Dublin)H-Index: 3
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CONTEXT Animal data and cross-sectional human studies have established that chronic hyponatraemia predisposes to osteoporosis; the effects of acute hyponatraemia on bone turnover have not been determined. Our objective was to test the hypothesis that acute hyponatraemia leads to dynamic effects on bone turnover. DESIGN A prospective observational pilot study. METHODS Bone turnover markers [C-terminal crosslinking telopeptide of type 1 collagen (CTX-1), N-propeptide of type 1 collagen (P1NP) and ...
Last. Glen A. Doherty (UCD: University College Dublin)H-Index: 31
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#1Malachi J. McKenna (UCD: University College Dublin)H-Index: 29
#2Rachel K Crowley (UCD: University College Dublin)H-Index: 17
Last. Mark Kilbane (UCD: University College Dublin)H-Index: 13
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Excess fibroblast growth factor 23 (FGF23), excess PTH, and an increase in extracellular calcium cause hypophosphatemia by lowering the maximum renal phosphate reabsorption threshold (TmP/GFR). We recently reported two cases of X-linked hypophosphatemia (XLH) with severe tertiary hyperparathyroidism who had normalization of TmP/GFR upon being rendered hypoparathyroid following total parathyroidectomy, despite marked excess in both C-terminal FGF23 (cFGF23) and intact FGF23 (iFGF23). We explored ...