Lidia Glodzik
New York University
Internal medicineEndocrinologyPathologyMagnetic resonance imagingOncologyPsychologyCardiologyNeuroscienceAmyloid betaDiseaseDementiaCerebrospinal fluidAtrophyFamily historyCognitive declineCognitive impairmentAlzheimer's diseaseApolipoprotein ENeuroimagingMedicineBiomarker (medicine)
Publications 97
#1Julia Neitzel (LMU: Ludwig Maximilian University of Munich)H-Index: 11
#2Nicolai Franzmeier (LMU: Ludwig Maximilian University of Munich)H-Index: 18
Last. William J. JagustH-Index: 140
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Klotho-VS heterozygosity (KL-VShet) is associated with reduced risk of Alzheimer’s disease (AD). However, whether KL-VShet is associated with lower levels of pathologic tau, i.e., the key AD pathology driving neurodegeneration and cognitive decline, is unknown. Here, we assessed the interaction between KL-VShet and levels of beta-amyloid, a key driver of tau pathology, on the levels of PET-assessed neurofibrillary tau in 551 controls and patients across the AD continuum. KL-VShet showed lower cr...
#1Ivan I. Kirov (NYU: New York University)H-Index: 21
#2Marc SollbergerH-Index: 15
Last. Oded Gonen (NYU: New York University)H-Index: 44
view all 9 authors...
We characterize the whole-brain N-acetyl-aspartate (WBNAA) and brain tissue fractions across the adult lifespan and test the hypothesis that, despite age-related atrophy, neuronal integrity (reflected by WBNAA) is preserved in normal aging. Two-hundred-and-seven participants: 133 cognitively intact older adults (73.6 ± 7.4 mean ± standard deviation, range: 60-90 year old) and 84 young (37.9 ± 11, range: 21-59 year old) were scanned with proton magnetic resonance spectroscopy and T1-weighted MRI....
#1Korey Kam (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 8
#2Ankit Parekh (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 12
Last. Ricardo S. Osorio (NYU: New York University)H-Index: 28
view all 25 authors...
Background Based on associations between sleep spindles, cognition, and sleep-dependent memory processing, here we evaluated potential relationships between levels of CSF Aβ42, P-tau, and T-tau with sleep spindle density and other biophysical properties of sleep spindles in a sample of cognitively normal elderly individuals.
22 CitationsSource
#1Chris Moran (Monash University)H-Index: 19
#2Richard Beare (Monash University)H-Index: 31
Last. Balebail Ashok RajH-Index: 8
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Objective To study longitudinal relationships between type 2 diabetes mellitus (T2DM), cortical thickness, and cognitive function in older people with normal cognition, mild cognitive impairment, and Alzheimer disease (AD). Methods The sample was derived from the Alzheimer9s Disease Neuroimaging Initiative cohort who underwent brain MRI and cognitive tests annually for 5 years. Presence of T2DM was based on fasting blood glucose ≥7.0mml/L or the use of glucose-lowering agents. We used latent gro...
25 CitationsSource
1 CitationsSource
#1Lidia Glodzik (NYU: New York University)H-Index: 34
#2Henry Rusinek (NYU: New York University)H-Index: 77
Last. Mony J. de Leon (NYU: New York University)H-Index: 86
view all 19 authors...
Although there is an increasing agreement that hypertension is associated with cerebrovascular compromise, relationships between blood pressure (BP) and cerebral blood flow are not fully understood. It is not known what BP level, and consequently what therapeutic goal, is optimal for brain perfusion. Moreover, there is limited data on how BP affects hippocampal perfusion, a structure critically involved in memory. We conducted a cross-sectional (n=445) and longitudinal (n=185) study of adults an...
10 CitationsSource
#1Ines Mahjoub (University of Sousse)H-Index: 1
#2Mohamed Ali Mahjoub (University of Sousse)H-Index: 12
Last. Kristin Fargher (USF: University of South Florida)H-Index: 8
view all 241 authors...
Accurate diagnosis of mild cognitive impairment (MCI) before conversion to Alzheimer's disease (AD) is invaluable for patient treatment. Many works showed that MCI and AD affect functional and structural connections between brain regions as well as the shape of cortical regions. However, 'shape connections' between brain regions are rarely investigated -e.g., how morphological attributes such as cortical thickness and sulcal depth of a specific brain region change in relation to morphological at...
61 CitationsSource
#1Yi LiH-Index: 94
#2Mony J. de Leon (NYU: New York University)H-Index: 86
Last. Henry RusinekH-Index: 77
view all 8 authors...
#1Tracy Butler (NYU: New York University)H-Index: 27
#2Patrick Harvey (NYU: New York University)H-Index: 4
Last. Mony J. de Leon (NYU: New York University)H-Index: 86
view all 15 authors...
Abstract Alzheimer's disease (AD) is known to be associated with loss of cholinergic neurons in the nucleus basalis of Meynert, located in the posterior basal forebrain. Structural changes of septal nuclei, located in the anterior basal forebrain, have not been well studied in AD. Using a validated algorithm, we manually traced septal nuclei on high-resolution coronal magnetic resonance imaging (MRI) in 40 subjects with mild cognitive impairment (MCI) or AD, 89 healthy controls, and 18 subjects ...
10 CitationsSource
#1Mony J. de Leon (NYU: New York University)H-Index: 86
#2Elizabeth Pirraglia (NYU: New York University)H-Index: 32
view all 15 authors...
Cerebrospinal fluid (CSF) studies consistently show that CSF levels of amyloid-beta 1–42 (Aβ42) are reduced and tau levels increased prior to the onset of cognitive decline related to Alzheimer’s disease (AD). However, the preclinical prediction accuracy for low CSF Aβ42 levels, a surrogate for brain Aβ42 deposits, is not high. Moreover, the pathology data suggests a course initiated by tauopathy contradicting the contemporary clinical view of an Aβ initiated cascade. CSF Aβ42 and tau data from ...
23 CitationsSource